Clinical Trials Browser

NCT05199584 2026-03-05

A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations

CNSDermatologicEndocrineHead & NeckOther solid neoplasmSarcomaThoracic

Uveal Melanoma, Glioma, Adenoma, Islet Cell, Laryngeal Diseases, Medulloblastoma, Melanoma, Mesothelioma, Neuroblastoma, Pituitary Diseases, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma

NCT02870907 2026-01-07

RB SFCE 09

Phase 2 Active not recruiting

195 enrolled

Other solid neoplasm

Retinoblastoma

NCT04040205 2025-07-20

Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration

Phase 2 Recruiting

44 enrolled

Other solid neoplasmSarcoma

Chondrosarcoma, Retinoblastoma, Sarcoma, Osteosarcoma

NCT06679634 2025-04-03

Retinoblastoma Phase II Expanded Access Clinical Trial

Phase 2 Recruiting

30 enrolled

Other solid neoplasm

Retinoblastoma

NCT01783535 2024-04-16

Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma

Phase 2 Active not recruiting

174 enrolled

Other solid neoplasm

Retinoblastoma

NCT00445965 2024-04-04

Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

Phase 2 Completed

78 enrolled 11 charts

CNSDermatologicGynecologicOther solid neoplasmSarcomaThoracic

Familial ependymoma, Uveal Melanoma, Astrocytoma, Brain Neoplasms, Chondrosarcoma, Ependymoma, Glioblastoma, Glioma, Lung Neoplasms, Medulloblastoma, Melanoma, Neoplasm Metastasis, Neuroblastoma, Oligodendroglioma, Ovarian Neoplasms, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Glioma, Subependymal, Gliosarcoma, Rhabdoid Tumor, Optic Nerve Glioma, Small Cell Lung Carcinoma, Desmoplastic Small Round Cell Tumor

NCT04990271 2021-08-04

A Clinical Study on the Efficacy and Safety of VEC Intravenous Chemotherapy Combined With Conbercept Intravitreal Injection in the Treatment of Retinoblastoma

Phase 2 Unknown

92 enrolled

Other solid neoplasm

Retinoblastoma

NCT00179920 2020-08-05

Chemotherapy Treatment for Children With Intraocular Germ-Line Retinoblastoma

Phase 2 Completed

30 enrolled

Other solid neoplasm

Retinoblastoma, Retinal Neoplasms

NCT01857752 2017-01-30

Phase II Study Temozolomide for Retinoblastoma Metastatic to the Central Nervous System for Patients From Guatemala

Phase 2 Terminated

3 enrolled

Other solid neoplasm

Retinoblastoma

NCT01393769 2016-08-02

Intra-arterial Chemotherapy With Melphalan for the Treatment of Retinoblastoma (RTB) in Advanced Intraocular Stage

Phase 2 Terminated

5 enrolled

Other solid neoplasm

Eye Neoplasms, Retinoblastoma

NCT00003273 2015-12-03

Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor

Phase 2 Withdrawn

CNSOther solid neoplasmSarcoma

Neuroblastoma, Retinoblastoma, Sarcoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms

NCT00024258 2015-11-25

Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors

Phase 2 Completed

22 enrolled 6 charts

CNSGastrointestinalGenitourinaryGynecologicOther solid neoplasmSarcoma

Ovarian Germ Cell Cancer, Kidney Neoplasms, Liver Neoplasms, Medulloblastoma, Wilms Tumor, Neuroblastoma, Ovarian Neoplasms, Retinoblastoma, Sarcoma, Osteosarcoma, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Desmoplastic Small Round Cell Tumor

NCT00831844 2015-03-30

Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors

Phase 2 Completed

116 enrolled 8 charts

CNSEndocrineGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Neuroectodermal Tumors, Hepatoblastoma, Adrenocortical Carcinoma

NCT00432445 2015-02-27

Proton Beam Radiation Therapy for Intraocular and Periocular Retinoblastoma

Phase 2 Terminated

2 enrolled 5 charts

Other solid neoplasm

Eye Neoplasms, Retinoblastoma

NCT01899066 2014-05-13

Efficacy Study of Lucentis in the Treatment of Retinoblastoma

Phase 2 Unknown

20 enrolled

Other solid neoplasm

Retinoblastoma

NCT00002675 2013-06-28

Chemotherapy in Treating Patients With Retinoblastoma

Phase 2 Completed

50 enrolled

Other solid neoplasm

Retinoblastoma

NCT00003173 2013-03-07

High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors

Phase 2 Completed

36 enrolled

CNSGenitourinaryGynecologicOther solid neoplasm

Ovarian Germ Cell Cancer, Testicular Germ Cell Tumor, Ovarian Neoplasms, Retinoblastoma, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms

NCT00006102 2013-02-05

Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma

Phase 2 Completed

200 enrolled

CNSLymphoidOther solid neoplasmSarcoma

Familial ependymoma, Astrocytoma, Burkitt Lymphoma, Lymphoma, Medulloblastoma, Neuroblastoma, Oligodendroglioma, Retinoblastoma, Sarcoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Optic Nerve Glioma, Dendritic Cell Sarcoma, Interdigitating

NCT01151748 2012-05-14

Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma

Phase 2 Withdrawn

Other solid neoplasm

Eye Neoplasms, Retinoblastoma

NCT00002794 2011-10-04

Carboplatin Plus Vincristine in Treating Children With Retinoblastoma

Phase 2 Completed

25 enrolled

Other solid neoplasm

Retinoblastoma

NCT00004006 2011-10-04

Combination Chemotherapy, Radiation Therapy, and Bone Marrow Transplantation in Treating Patients With Retinoblastoma

Phase 2 Completed

4 enrolled

Other solid neoplasm

Retinoblastoma