Clinical Trials

Phase 1 Active not recruiting

Retinoblastoma

NCT03618381 2025-11-20

EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

44 enrolled

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Carcinoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Hepatoblastoma, Sarcoma, Clear Cell, Neurofibrosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT04483778 2025-11-20

B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

Phase 1 Active not recruiting

68 enrolled

CNSDermatologicGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Carcinoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Hepatoblastoma, Sarcoma, Clear Cell, Neurofibrosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT03016156 2025-11-10

Determination of the Sensitivity and Specificity of a Smartphone Application to Detect Retinoblastoma

Phase NA Terminated

1 enrolled

Hydrophthalmos, Retinoblastoma

NCT04344652 2025-09-26

Photoscreening for Retinoblastoma

Phase NA Withdrawn

Retinoblastoma

NCT00186888 2025-09-04

Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma

Phase 3 Completed

107 enrolled 34 charts

Other solid neoplasmSarcoma

Eye Neoplasms, Retinoblastoma, Retinal Neoplasms

NCT04040205 2025-07-20

Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration

Phase 2 Recruiting

44 enrolled

Chondrosarcoma, Retinoblastoma, Sarcoma, Osteosarcoma

NCT06972602 2025-05-15

High-dose Topotecan for Retinoblastoma With Recurrent or Refractory Vitreous Seed

Phase EARLY_PHASE1 Recruiting

Recurrence, Retinoblastoma

NCT04342572 2025-05-11

IAC

5 enrolled

Retinoblastoma

NCT04903678 2025-02-25

Intrathecal Chemotherapy for Central Nervous System Metastasis in Retinoblastoma

Phase NA Recruiting

18 enrolled

Retinoblastoma

NCT03284268 2024-08-27

RTB

13 enrolled

Phase 2 Active not recruiting

Recurrence, Retinoblastoma

NCT01783535 2024-04-16

Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma

174 enrolled

Retinoblastoma

NCT00445965 2024-04-04

Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

CNSDermatologicGynecologicOther solid neoplasmSarcomaThoracic

78 enrolled 11 charts

Familial ependymoma, Uveal Melanoma, Astrocytoma, Brain Neoplasms, Chondrosarcoma, Ependymoma, Glioblastoma, Glioma, Lung Neoplasms, Medulloblastoma, Melanoma, Neoplasm Metastasis, Neuroblastoma, Oligodendroglioma, Ovarian Neoplasms, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Glioma, Subependymal, Gliosarcoma, Rhabdoid Tumor, Optic Nerve Glioma, Small Cell Lung Carcinoma, Desmoplastic Small Round Cell Tumor

NCT01505569 2024-02-26

Auto Transplant for High Risk or Relapsed Solid or CNS Tumors

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

44 enrolled

Brain Neoplasms, Carcinoma, Renal Cell, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Central Nervous System Neoplasms, Hepatoblastoma, Rhabdoid Tumor

NCT04564521 2023-11-22

Nitroglycerin for Intra-arterial Chemotherapy in Pediatric Retinoblastoma.

Phase NA Unknown

36 enrolled

Retinoblastoma

NCT03677128 2023-05-09

Mobile Health Case Management System for Reducing Pediatric Treatment Abandonment

LymphoidOther solid neoplasm

75 enrolled 12 charts

Burkitt Lymphoma, Neoplasms, Retinoblastoma, Lymphoma, Large B-Cell, Diffuse

NCT04700514 2023-04-24

Effect of Anesthetic Drugs on Neurocognitive Function in Children With Retinoblastoma Requiring Multiple Anesthetic Exposure - Preliminary Study

Phase NA Unknown

60 enrolled

Retinoblastoma

NCT05080010 2021-10-15

Adjuvant Chemotherapy for High-risk Postenucleation Retinoblastoma

Phase 3 Recruiting

500 enrolled

Retinoblastoma

NCT04383860 2021-06-15

Sutures in Orbital Implants in Retinoblastoma Patients

132 enrolled

Retinoblastoma

NCT04799002 2021-03-16

Topotecan and Melphalan for Retinoblastoma

Phase 3 Recruiting

50 enrolled

CNSGenitourinaryOther solid neoplasmSarcoma

Retinoblastoma

NCT01987596 2020-10-29

Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer

Phase 3 Terminated

23 enrolled 9 charts

Medulloblastoma, Wilms Tumor, Neuroblastoma, Recurrence, Retinoblastoma, Osteosarcoma, Choroid Plexus Neoplasms

NCT01466855 2020-09-14

IARB1

Phase EARLY_PHASE1 Terminated

36 enrolled

Retinoblastoma

NCT00179920 2020-08-05

Chemotherapy Treatment for Children With Intraocular Germ-Line Retinoblastoma

30 enrolled

Retinoblastoma, Retinal Neoplasms

NCT01331135 2020-05-29

Aflac ST0901

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

18 enrolled

Astrocytoma, Carcinoma, Renal Cell, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Recurrence, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Rhabdoid Tumor

NCT02116959 2020-04-16

Alternating Systemic Chemotherapy and Intra-Arterial Melphalan (IAM) Chemotherapy in Children With Intra-Ocular Retinoblastoma

Phase 1 Terminated

6 enrolled

Retinoblastoma

NCT02390843 2020-04-03

AflacST1402

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

13 enrolled

Carcinoma, Renal Cell, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Rhabdoid Tumor

NCT02792036 2020-02-20

Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblastoma

8 enrolled

CNSGastrointestinalLymphoidOther hematologic neoplasmOther solid neoplasm

Retinoblastoma

NCT02933333 2018-10-17

G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor

Phase 4 Unknown

405 enrolled

Lymphoma, Neuroblastoma, Retinoblastoma, Leukemia, Myeloid, Acute, Hepatoblastoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT03439397 2018-03-01

RCT of Ballon Technique VS Selective Ophthalmic Artery Infusion For the Retinoblastoma Patients

Phase NA Unknown

496 enrolled

Retinoblastoma

NCT02617862 2018-02-12

PCI Imaging System in Pediatric Ophthalmology

Phase NA Terminated

6 enrolled

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Retinoblastoma

NCT00623077 2017-12-05

MT2004-30: Tomotherapy for Solid Tumors

Phase 1 Terminated

23 enrolled

Familial ependymoma, Astrocytoma, Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Kidney Neoplasms, Liver Neoplasms, Medulloblastoma, Wilms Tumor, Retinoblastoma, Sarcoma, Central Nervous System Neoplasms, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor, Optic Nerve Glioma

NCT00003926 2017-11-29

Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumors

Phase 1 Terminated

13 enrolled

CNSGastrointestinalGenitourinaryGynecologicOther solid neoplasmSarcoma

Ovarian Germ Cell Cancer, Astrocytoma, Brain Neoplasms, Chordoma, Ependymoma, Glioma, Kidney Neoplasms, Liver Neoplasms, Medulloblastoma, Wilms Tumor, Neuroblastoma, Ovarian Neoplasms, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Neuroectodermal Tumors, Hepatoblastoma, Desmoplastic Small Round Cell Tumor

NCT01857752 2017-01-30

Phase II Study Temozolomide for Retinoblastoma Metastatic to the Central Nervous System for Patients From Guatemala

Phase 2 Terminated

3 enrolled

Retinoblastoma

NCT00857519 2016-12-12

IAC-RB

Retinoblastoma

NCT00906113 2016-10-04

Intra-arterial Chemotherapy for Children With Retinoblastoma

Phase 1/2 Unknown

Retinoblastoma

NCT01393769 2016-08-02

Intra-arterial Chemotherapy With Melphalan for the Treatment of Retinoblastoma (RTB) in Advanced Intraocular Stage

Phase 2 Terminated

5 enrolled

CNSOther solid neoplasmSarcoma

Eye Neoplasms, Retinoblastoma

NCT00003273 2015-12-03

Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor

Phase 2 Withdrawn

Neuroblastoma, Retinoblastoma, Sarcoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms

NCT00024258 2015-11-25

Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors

CNSGastrointestinalGenitourinaryGynecologicOther solid neoplasmSarcoma

22 enrolled 6 charts

Ovarian Germ Cell Cancer, Kidney Neoplasms, Liver Neoplasms, Medulloblastoma, Wilms Tumor, Neuroblastoma, Ovarian Neoplasms, Retinoblastoma, Sarcoma, Osteosarcoma, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Desmoplastic Small Round Cell Tumor

NCT01558960 2015-08-20

Intravitreal Injections of Melphalan for Retinoblastoma

Phase NA Terminated

Retinoblastoma

NCT02319486 2015-03-30

CEV With/Without Periocular Carboplatin Chemotherapy for Extraocular Retinoblastoma

Phase 4 Completed

26 enrolled 7 charts

Retinoblastoma

NCT00432445 2015-02-27

Proton Beam Radiation Therapy for Intraocular and Periocular Retinoblastoma

Phase 2 Terminated

2 enrolled 5 charts

Eye Neoplasms, Retinoblastoma

NCT02137928 2014-12-19

Carboplatin Periocular Injection for Retinoblastoma

Phase 3 Unknown

50 enrolled

Retinoblastoma

NCT01899066 2014-05-13

Efficacy Study of Lucentis in the Treatment of Retinoblastoma

Phase 2 Unknown

20 enrolled

Retinoblastoma

NCT00003022 2013-07-03

Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer

CNSDermatologicOther solid neoplasmSarcomaThoracic

Familial ependymoma, Uveal Melanoma, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Lung Neoplasms, Medulloblastoma, Melanoma, Neuroblastoma, Oligodendroglioma, Retinoblastoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Neuroectodermal Tumors, Primitive, Gliosarcoma, Optic Nerve Glioma, Small Cell Lung Carcinoma

NCT00002675 2013-06-28

Chemotherapy in Treating Patients With Retinoblastoma

50 enrolled

Retinoblastoma

NCT00003173 2013-03-07

High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors

CNSGenitourinaryGynecologicOther solid neoplasm

36 enrolled

Ovarian Germ Cell Cancer, Testicular Germ Cell Tumor, Ovarian Neoplasms, Retinoblastoma, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms

NCT01151748 2012-05-14

Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma

Phase 2 Withdrawn

Eye Neoplasms, Retinoblastoma

NCT00002794 2011-10-04

Carboplatin Plus Vincristine in Treating Children With Retinoblastoma

25 enrolled