Clinical Trials

CNSDermatologicGastrointestinalGenitourinaryLymphoidSarcoma

23 enrolled

Carcinoma, Renal Cell, Digestive System Neoplasms, Carcinoma, Hepatocellular, Lymphoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Adenocarcinoma, Clear Cell, Rhabdoid Tumor

NCT03251989 2026-01-08

Rare CNS Tumors Outcomes &Risk

Completed

326 enrolled

Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT03638167 2025-12-17

EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors

11 enrolled

CNSGastrointestinalGenitourinarySarcoma

Choroid Plexus Carcinoma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT02162732 2025-11-03

Molecular-Guided Therapy for Childhood Cancer

Phase NA Completed

186 enrolled 12 charts

Carcinoma, Renal Cell, Craniopharyngioma, Ependymoma, Glioma, Carcinoma, Hepatocellular, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Choroid Plexus Neoplasms, Sarcoma, Clear Cell, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT02905110 2025-03-25

Methotrexate and Etoposide Infusions Into the Fourth Ventricle in Children with Recurrent Posterior Fossa Brain Tumors

Phase EARLY_PHASE1 Completed

3 enrolled

Brain Neoplasms, Ependymoma, Medulloblastoma, Rhabdoid Tumor

NCT04537715 2025-02-19

Effects of Itraconazole and Rifampin on the Blood Tazemetostat Levels

LymphoidOther hematologic neoplasmOther solid neoplasmSarcomaThoracic

42 enrolled 39 charts

Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Mesothelioma, Sarcoma, Sarcoma, Synovial, Lymphoma, Large B-Cell, Diffuse, Rhabdoid Tumor, Hematologic Neoplasms

NCT03213665 2025-01-27

Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial)

CNSGastrointestinalGenitourinaryLymphoidMyeloidSarcoma

20 enrolled 12 charts

Ependymoma, Glioma, Histiocytosis, Langerhans-Cell, Hodgkin Disease, Lymphoma, Non-Hodgkin, Medulloblastoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Central Nervous System Neoplasms, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor

NCT03213678 2025-01-27

Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)

CNSGastrointestinalGenitourinaryLymphoidMyeloidSarcoma

18 enrolled 12 charts

Ependymoma, Glioma, Histiocytosis, Langerhans-Cell, Lymphoma, Non-Hodgkin, Medulloblastoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Central Nervous System Neoplasms, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor

NCT03220035 2025-01-27

Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial)

CNSGastrointestinalGenitourinaryLymphoidMyeloidSarcoma

4 enrolled 12 charts

Ependymoma, Glioma, Histiocytosis, Langerhans-Cell, Lymphoma, Non-Hodgkin, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Central Nervous System Neoplasms, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor

NCT03233204 2024-12-11

Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial)

CNSGastrointestinalGenitourinaryLymphoidMyeloidSarcoma

6 enrolled 12 charts

Familial ependymoma, Ependymoma, Glioma, Histiocytosis, Langerhans-Cell, Lymphoma, Non-Hodgkin, Medulloblastoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor

NCT03526250 2024-11-01

Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial)

CNSGastrointestinalGenitourinaryLymphoidMyeloidSarcoma

23 enrolled 11 charts

Familial ependymoma, Ependymoma, Glioma, Histiocytosis, Langerhans-Cell, Lymphoma, Non-Hodgkin, Medulloblastoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor

NCT02601937 2024-10-03

EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma

109 enrolled 25 charts

Sarcoma

Sarcoma, Synovial, Rhabdoid Tumor

NCT03434262 2024-05-31

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

68 enrolled

CNSLymphoid

Choroid Plexus Carcinoma, Microphthalmia, Isolated, with Coloboma 5, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Lymphoma, Follicular, Medulloblastoma, Meningioma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Oligodendroglioma, Pinealoma, Recurrence, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Rhabdoid Tumor, Pyloric Stenosis, Hypertrophic

NCT00653068 2024-04-23

Combination Chemotherapy, Radiation Therapy, and an Autologous Peripheral Blood Stem Cell Transplant in Treating Young Patients With Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System

Phase 3 Completed

70 enrolled 12 charts

Rhabdoid Tumor

NCT00445965 2024-04-04

Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

CNSDermatologicGynecologicOther solid neoplasmSarcomaThoracic

78 enrolled 11 charts

Familial ependymoma, Uveal Melanoma, Astrocytoma, Brain Neoplasms, Chondrosarcoma, Ependymoma, Glioblastoma, Glioma, Lung Neoplasms, Medulloblastoma, Melanoma, Neoplasm Metastasis, Neuroblastoma, Oligodendroglioma, Ovarian Neoplasms, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Glioma, Subependymal, Gliosarcoma, Rhabdoid Tumor, Optic Nerve Glioma, Small Cell Lung Carcinoma, Desmoplastic Small Round Cell Tumor

NCT02962167 2024-03-20

Modified Measles Virus (MV-NIS) for Children and Young Adults With Recurrent Medulloblastoma or Recurrent ATRT

34 enrolled

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Medulloblastoma, Recurrence, Rhabdoid Tumor

NCT01505569 2024-02-26

Auto Transplant for High Risk or Relapsed Solid or CNS Tumors

Phase NA Completed

44 enrolled

Brain Neoplasms, Carcinoma, Renal Cell, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Central Nervous System Neoplasms, Hepatoblastoma, Rhabdoid Tumor

NCT00085202 2024-02-08

Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor

Phase 3 Completed

416 enrolled 16 charts

Central Nervous System Neoplasms, Rhabdoid Tumor

NCT02457845 2024-01-19

HSV G207 Alone or With a Single Radiation Dose in Children With Progressive or Recurrent Supratentorial Brain Tumors

13 enrolled

CNSSarcoma

Choroid Plexus Carcinoma, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Oligodendroglioma, Virus Diseases, Supratentorial Neoplasms, Neuroectodermal Tumors, Primitive, Gliosarcoma, Rhabdoid Tumor

NCT02644460 2023-10-26

AflacST1501

53 enrolled

CNSSarcoma

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT04956198 2023-02-14

Drug Sensitivity and Mutation Profiling

Completed

14 enrolled

GenitourinarySarcoma

Wilms Tumor, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT03387020 2021-08-27

Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors

22 enrolled 16 charts

Familial ependymoma, Diffuse Intrinsic Pontine Glioma, Glioma, Medulloblastoma, Rhabdoid Tumor

NCT00179803 2020-08-05

Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors

24 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Supratentorial Neoplasms, Central Nervous System Neoplasms, Rhabdoid Tumor

NCT01331135 2020-05-29

Aflac ST0901

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

18 enrolled

Astrocytoma, Carcinoma, Renal Cell, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Recurrence, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Rhabdoid Tumor

NCT02390843 2020-04-03

AflacST1402

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

13 enrolled

Carcinoma, Renal Cell, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Rhabdoid Tumor

NCT00007813 2020-02-17

Peripheral Stem Cell Transplantation Plus Chemotherapy in Treating Patients With Malignant Solid Tumors

CNSGastrointestinalGenitourinaryGynecologicSarcoma

21 enrolled

Familial ependymoma, Ovarian Germ Cell Cancer, Testicular Germ Cell Tumor, Astrocytoma, Liver Neoplasms, Medulloblastoma, Neuroblastoma, Oligodendroglioma, Ovarian Neoplasms, Sarcoma, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor, Optic Nerve Glioma

NCT01737671 2018-01-19

Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study

Phase EARLY_PHASE1 Completed

7 enrolled

Brain Neoplasms, Ependymoma, Medulloblastoma, Rhabdoid Tumor

NCT01553175 2016-07-14

Studying Gene Expression in Samples From Patients With Rhabdoid Tumors

Completed

25 enrolled

CNSGenitourinary

Kidney Neoplasms, Central Nervous System Neoplasms, Rhabdoid Tumor

NCT00326664 2016-03-07

AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors

55 enrolled

Familial ependymoma, Astrocytoma, Medulloblastoma, Oligodendroglioma, Spinal Cord Neoplasms, Rhabdoid Tumor, Optic Nerve Glioma

NCT01292707 2014-11-19

TACT

Phase NA Completed

1,152 enrolled

Fever, Malaria, Rhabdoid Tumor

NCT00217412 2014-06-17

Vorinostat With or Without Isotretinoin in Treating Young Patients With Recurrent or Refractory Solid Tumors, Lymphoma, or Leukemia

CNSLymphoidOther hematologic neoplasmSarcoma

60 enrolled

Burkitt Lymphoma, Medulloblastoma, Neuroblastoma, Recurrence, Lymphoma, Large B-Cell, Diffuse, Rhabdoid Tumor, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile, Dendritic Cell Sarcoma, Interdigitating

NCT00003141 2014-03-28

Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors

94 enrolled

CNSSarcoma

Astrocytoma, Brain Neoplasms, Neuroblastoma, Sarcoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor

NCT00100880 2013-09-30

Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors

45 enrolled

Familial ependymoma, Astrocytoma, Medulloblastoma, Oligodendroglioma, Choroid Plexus Neoplasms, Rhabdoid Tumor, Optic Nerve Glioma

NCT00303940 2012-03-15

Talabostat Combined With Temozolomide or Carboplatin in Treating Young Patients With Relapsed or Refractory Brain Tumors or Other Solid Tumors

CNSGastrointestinalGenitourinaryGynecologicSarcoma

26 enrolled

Familial ependymoma, Ovarian Germ Cell Cancer, Astrocytoma, Kidney Neoplasms, Liver Neoplasms, Medulloblastoma, Wilms Tumor, Neuroblastoma, Oligodendroglioma, Ovarian Neoplasms, Sarcoma, Osteosarcoma, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor, Optic Nerve Glioma

NCT00015899 2009-10-14

SCH 66336 in Treating Children With Recurrent or Progressive Brain Tumors

53 enrolled