Clinical Trials

Squamous Cell Carcinoma of Head and Neck

NCT03313804 2026-03-11

Priming Immunotherapy in Advanced Disease With Radiation

Phase 3 Active not recruiting

76 enrolled 9 charts

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung

NCT05721755 2026-03-05

Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and Neck

290 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT06992427 2026-03-04

HOPE

Phase 3 Recruiting

228 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07026474 2026-03-02

RePaIr-HN

Phase 3 Recruiting

214 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT05268614 2026-02-18

Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell Carcinoma

250 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT05962242 2026-02-05

HN001

90 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03040999 2026-02-04

KEYNOTE-412

Phase 3 Completed

804 enrolled 20 charts

Parkinson Disease 4, Autosomal Dominant Lewy Body, Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04754321 2026-02-02

Combining Immunotherapy Salvage Surgery & IORT Tx Persistent/Recurrent Head & Neck Cancer

Phase 1 Recruiting

45 enrolled

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07379424 2026-01-30

A Single-arm, Phase II, Multi-center Clinical Trial of Sintilimab During the Perioperative Period in Patients With Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma

37 enrolled

Phase 1/2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT03474497 2026-01-29

UCDCC#272: IL-2, Radiotherapy, and Pembrolizumab in Patients Refractory to Checkpoint Blockade

18 enrolled 13 charts

DermatologicGenitourinaryHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Melanoma

NCT07369882 2026-01-27

Comparison of Efficacy Between De-escalated Surgery and Standard Surgery After Neoadjuvant Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase NA Recruiting

60 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT03829722 2026-01-22

Radiotherapy, Carboplatin/Paclitaxel and Nivolumab for High Risk HPV-related Head and Neck Cancer

26 enrolled 13 charts

Squamous Cell Carcinoma of Head and Neck

NCT02819752 2026-01-21

PEACH

Phase 1 Terminated

3 enrolled 12 charts

Phase 3 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT07320690 2026-01-06

Neo-Margin

356 enrolled

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT01154920 2025-12-17

Paclitaxel, Carboplatin and Cetuximab (PCC) With Cetuximab, Docetaxel, Cisplatin and Fluorouracil (C-TPF) in Previously Untreated Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma

128 enrolled

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03224000 2025-12-17

Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer

90 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT00875849 2025-09-30

AACER

53 enrolled

Phase EARLY_PHASE1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Tongue Neoplasms

NCT07168785 2025-09-11

[18F]-AraG PET Imaging in LA HNSCC

5 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07121595 2025-08-13

Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT07090707 2025-07-29

PD-1 Inhibitor Therapy Versus Radiotherapy in MPR Patients With Locally Advanced HNSCC After Neoadjuvant Immunochemotherapy (HNC-SYSU-006)

Phase 1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT06110195 2025-06-08

Study of Xevinapant With Radiation and Chemotherapy for Patients With Head and Neck Cancer

42 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06494995 2025-06-04

AK104 and Low-dose Radiation in Recurrent/Metastatic HNSCC After Failure of First-line Systemic Therapy

52 enrolled

Diabetes Mellitus, Insulin-Dependent, 12, Squamous Cell Carcinoma of Head and Neck

NCT02318771 2025-05-15

Radiation Therapy and MK-3475 for Patients With Recurrent/Metastatic Head and Neck Cancer, Renal Cell Cancer, Melanoma, and Lung Cancer

DermatologicGenitourinaryHead & NeckThoracic

41 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Renal Cell, Lung Neoplasms, Melanoma

NCT02998385 2025-05-07

SANTAL

Phase 3 Active not recruiting

342 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT01783587 2025-05-01

Safety Study of Afatinib and Postoperative Radiation Therapy to Treat Head and Neck Cancer

29 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06673693 2025-04-16

NEOSTART

24 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT05608369 2025-04-04

HPV

Phase 2 Withdrawn

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT05784012 2025-03-13

RADIAN

Phase 1/2 Recruiting

34 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Laryngeal Diseases, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT04091867 2025-02-24

sEphB4-HSA With RT+Chemo or Cetux in Patients With Intermediate to High Risk LAHNSCC

3 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT00544414 2025-02-19

Chemotherapy Followed by Surgery, Chemotherapy, and Radiation Therapy in Treating Patients With Locally Advanced Head And Neck Cancer

31 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00559156 2025-02-13

Arginine/Omega-3 Fatty Acids/Nucleotides Nutritional Supplement in Treating Patients With Stage III or Stage IV Head and Neck Cancer Undergoing Chemotherapy and Radiation Therapy

46 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Salivary Gland Neoplasms

NCT03715946 2025-01-13

Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer

40 enrolled 69 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT06725498 2024-12-10

Intra-arterial Chemotherapy Combined with Radiotherapy and Immunotherapy for HNSCC

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT04452032 2024-11-08

StomRay

40 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT02258659 2024-09-24

OPTIMA

62 enrolled 13 charts

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT03028766 2024-09-19

WISTERIA

9 enrolled

Squamous Cell Carcinoma of Head and Neck, Laryngeal Neoplasms

NCT00720304 2024-08-22

Erlotinib, Docetaxel, and Radiation Therapy in Stage III or Stage IV Squamous Cell Carcinoma of the Head and Neck

43 enrolled 16 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT01847326 2024-07-31

Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Carboplatin Followed By Chemoradiation in Treating Patients With Recurrent Head and Neck Cancer

48 enrolled

Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms

NCT02072148 2024-05-06

The Sinai Robotic Surgery Trial in HPV Positive Oropharyngeal Squamous Cell Carcinoma (SCCA) (SIRS TRIAL)

Phase NA Completed

112 enrolled 11 charts

Squamous Cell Carcinoma of Head and Neck

NCT06170697 2023-12-20

Advanced First-line Treatment of Short-term Postoperative Progression of Head and Neck Squamous Cell Carcinoma

Phase 2 Unknown

46 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT03624231 2023-08-31

DURTRE-RAD

18 enrolled

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT05993858 2023-08-15

PC-1

33 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT04572100 2023-07-07

Pilot Study of Chemotherapy for HPV-Associated Oropharyngeal Cancer

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00096174 2023-06-29

Phase II Study of Concurrent C225, Cisplatin and Radiation in Stage IV Squamous Cell Carcinoma of the Head and Neck

69 enrolled 7 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00014118 2023-06-15

Chemotherapy and Radiation Therapy in Treating Patients With Stage III or Stage IV Larynx or Oropharynx Cancer

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05872880 2023-05-24

TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma.

Recruiting

124 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT01590355 2023-03-08

ORATOR

Phase 2 Unknown

68 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT05749042 2023-03-01

A Study of Concurrent Chemoradiotherapy Based of Cisplatin With or Without Sintilimab as First-line Therapy for Patients With Advanced Oral Cavity Squamous Cell Carcinoma

Phase 2 Unknown

70 enrolled