Clinical Trials Browser

Squamous Cell Carcinoma of Head and Neck

NCT06992427 2026-03-04

HOPE

Phase 3 Recruiting

228 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT07026474 2026-03-02

RePaIr-HN

Phase 3 Recruiting

214 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT05268614 2026-02-18

Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell Carcinoma

Phase 2 Recruiting

250 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT05962242 2026-02-05

HN001

Phase 2 Recruiting

90 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04754321 2026-02-02

Combining Immunotherapy Salvage Surgery & IORT Tx Persistent/Recurrent Head & Neck Cancer

Phase 1 Recruiting

45 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT07369882 2026-01-27

Comparison of Efficacy Between De-escalated Surgery and Standard Surgery After Neoadjuvant Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase NA Recruiting

60 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT06998069 2025-12-30

Head and Neck Cancer Study Project in the Geriatric Population

Phase 3 Recruiting

20 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07121595 2025-08-13

Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial

Phase 2 Recruiting

50 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT06494995 2025-06-04

AK104 and Low-dose Radiation in Recurrent/Metastatic HNSCC After Failure of First-line Systemic Therapy

Phase 2 Recruiting

52 enrolled

Head & Neck

Diabetes Mellitus, Insulin-Dependent, 12, Squamous Cell Carcinoma of Head and Neck

NCT06673693 2025-04-16

NEOSTART

Phase 2 Recruiting

24 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT05784012 2025-03-13

RADIAN

Phase 1/2 Recruiting

34 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Laryngeal Diseases, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT06725498 2024-12-10

Intra-arterial Chemotherapy Combined with Radiotherapy and Immunotherapy for HNSCC

Phase 2 Recruiting

50 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT05872880 2023-05-24

TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma.

Recruiting

124 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT05343325 2022-12-29

The Efficacy and Safety of Neoadjuvant Low-dose Radiotherapy Combined With Chemoimmunotherapy in Locally Advanced HNSCC

Phase 2 Recruiting

25 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

Clinical Trials

JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC

HOPE

RePaIr-HN

Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell Carcinoma

HN001

Combining Immunotherapy Salvage Surgery & IORT Tx Persistent/Recurrent Head & Neck Cancer

Comparison of Efficacy Between De-escalated Surgery and Standard Surgery After Neoadjuvant Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma

Head and Neck Cancer Study Project in the Geriatric Population

Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial

AK104 and Low-dose Radiation in Recurrent/Metastatic HNSCC After Failure of First-line Systemic Therapy

NEOSTART

RADIAN

Intra-arterial Chemotherapy Combined with Radiotherapy and Immunotherapy for HNSCC

TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma.

The Efficacy and Safety of Neoadjuvant Low-dose Radiotherapy Combined With Chemoimmunotherapy in Locally Advanced HNSCC