Clinical Trials

Squamous Cell Carcinoma of Head and Neck

NCT07400094 2026-02-10

NeoCamre-HN

Squamous Cell Carcinoma of Head and Neck, Laryngeal Neoplasms, Mouth Neoplasms

NCT07392580 2026-02-06

Intralesional Chemotherapy (IC): Cisplatin + Epinephrine

20 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07393477 2026-02-06

Neoadjuvant Becotatug Vedotin Plus Pucotenlimab and Cisplatin for Locally Advanced Head and Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma of Head and Neck

NCT07214987 2026-01-30

PDT For Induction Therapy For Head And Neck Cancer

26 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT07379424 2026-01-30

A Single-arm, Phase II, Multi-center Clinical Trial of Sintilimab During the Perioperative Period in Patients With Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma

37 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07361133 2026-01-22

Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell Cancer

120 enrolled

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis, Recurrence

NCT07354984 2026-01-21

PIONEER-HN

Squamous Cell Carcinoma of Head and Neck

NCT06769698 2025-12-16

A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

120 enrolled

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis, Recurrence

NCT07058805 2025-10-02

COMPORT

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07137858 2025-08-22

Adebrelimab Combined With Carboplatin and Albumin-bound Taxanol in the Treatment of Resectable Locally Advanced Oral Squamous Cell Carcinoma Cardiac, Randomized, Phase II Exploratory Study

70 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07090707 2025-07-29

PD-1 Inhibitor Therapy Versus Radiotherapy in MPR Patients With Locally Advanced HNSCC After Neoadjuvant Immunochemotherapy (HNC-SYSU-006)

Squamous Cell Carcinoma of Head and Neck

NCT06861712 2025-04-25

Chemoimmunotherapy With or Without SBRT Before Surgery for Locally Advanced Oral and Oropharyngeal Cancer

Squamous Cell Carcinoma of Head and Neck

NCT06895369 2025-03-26

The Efficacy and Safety of Pucotenlimab Combined With TP Chemotherapy as Neoadjuvant Therapy for Locally Advanced HNSCC

Squamous Cell Carcinoma of Head and Neck

NCT05835804 2025-03-21

NIVOCHIMLOC

39 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT05752149 2025-02-26

STELLAR

27 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06814067 2025-02-07

Phase II Multi-centered Study of Perioperative Ivonescimab Versus Pembrolizumab Combined with Standard of Care (SOC) in Patients with Resectable, Locally Advanced Head and Neck Squamous Cell Carcinoma

80 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06759155 2025-01-06

Phase II Clinical Trial of De-Intensified Therapy in Human Papilloma Virus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma

20 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06728618 2024-12-11

OSCC

28 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06714266 2024-12-03

Trilaciclib in Preventing Hematopoietic Suppression in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma of Head and Neck

NCT06699498 2024-11-21

Neoadjuvant Therapy of Targeted Immunotherapy Combined With Chemotherapy for Locally Advanced HNSCC

45 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06694350 2024-11-19

Pembrolizumab in Combination with Flutamide Treatment for Recurrence / Metastasis HNSCC

54 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06578871 2024-09-03

SUPERIOR

90 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT06530914 2024-07-31

A Phase II Study of MRG003 Injection Combined With Pucotenlimab Injection ± Cisplatin Injection in the Neoadjuvant Treatment Locally Advanced EGFR-positive Head and Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma of Head and Neck

NCT06509997 2024-07-19

A Phase II Study of Anti-EGFR Antibody-drug Conjugate (ADC) Combine With CDK4/6 Inhibitors Posterior Line in the Treatment of Recurrent/Metastatic CDKN2A Gene Variant Head and Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma of Head and Neck

NCT06366945 2024-04-16

Tirelizumab in Combination With Carboplatin and Polymeric Micellar Paclitaxel for Neoadjuvant Therapy in cN+ HNSCC

85 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05773079 2024-04-01

Toripalimab Maintenance for Locally Advanced Head and Neck Squamous Cell Carcinoma

28 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06297811 2024-03-07

Myeloprotection With Trilaciclib in Pan-cancer Population

BreastGynecologicHead & NeckThoracic

132 enrolled

Squamous Cell Carcinoma of Head and Neck, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Endometrial Neoplasms

NCT06199271 2024-01-22

Neoadjuvant Adebrelimab Plus Dalpiciclib in Head and Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma of Head and Neck

NCT06016413 2023-08-29

Adelbelimab Combination Chemotherapy in Neoadjuvant Therapy for Squamous Cell Carcinoma of the Head and Neck

Squamous Cell Carcinoma of Head and Neck

NCT05993858 2023-08-15

PC-1

33 enrolled