Clinical Trials

40 enrolled 20 charts

BreastCNSDermatologicEndocrineHead & NeckNETThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT04119024 2026-03-17

Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

Phase 1 Recruiting

18 enrolled

Adenocarcinoma of Lung, Squamous Cell Carcinoma of Head and Neck, Uveal Melanoma, Breast Neoplasms, Adenoma, Islet Cell, Melanoma, Neoplasm Metastasis, Paraganglioma, Pheochromocytoma, Thyroid Neoplasms, Adrenocortical Carcinoma, Neuroendocrine Tumors

NCT05120947 2026-03-17

HART-HN

Phase NA Completed

18 enrolled 11 charts

Squamous Cell Carcinoma of Head and Neck

NCT05539638 2026-03-17

The Role of Circulating Tumour DNA in Head and Neck Cancer

Recruiting

250 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT04042935 2026-03-16

Alpha Lipoic Acid to Decrease Pain and Side Effects in Concurrent Treatment of HNSCC

Phase 1 Completed

5 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06030440 2026-03-13

DIREKHT2

Phase 2/3 Recruiting

508 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07471009 2026-03-13

SPAR

Not yet recruiting

120 enrolled

Squamous Cell Carcinoma of Head and Neck, Neoplasms

NCT03386357 2026-03-12

Radiotherapy With Pembrolizumab in Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)

Phase 2 Terminated

115 enrolled 15 charts

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

Squamous Cell Carcinoma of Head and Neck

NCT05269381 2026-03-12

PNeoVCA

Phase 1/2 Recruiting

132 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Carcinosarcoma, Uterine Cervical Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Carcinoma, Merkel Cell, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT06211335 2026-03-12

Losartan, Pembrolizumab and Stereotactic Body Radiation Therapy for the Treatment of Patients With Locally Recurrent, Refractory or Oligometastatic Head and Neck Squamous Cell Carcinoma

Phase 1 Recruiting

24 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06947668 2026-03-12

DoIT_Neck

Recruiting

250 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT03313804 2026-03-11

Priming Immunotherapy in Advanced Disease With Radiation

76 enrolled 9 charts

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung

NCT04696744 2026-03-11

CTCO

Completed

12 enrolled

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Neoplastic Cells, Circulating, Oropharyngeal Neoplasms

NCT07465276 2026-03-11

Neoadjuvant Ficerafusp Alfa With Pembrolizumab in Resectable SCC

32 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT03370276 2026-03-10

Cetuximab & Nivolumab in Patients With Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma

Phase 1/2 Completed

95 enrolled 15 charts

Phase 1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Neoplasms, Squamous Cell

NCT07460765 2026-03-10

Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)

40 enrolled

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Mouth Neoplasms, Neoplasms, Squamous Cell

NCT04030455 2026-03-09

Cisplatin, Docetaxel, and Pembrolizumab in Treating Patients With Stage II-III Laryngeal Cancer

28 enrolled 13 charts

Phase 1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Laryngeal Neoplasms

NCT07455032 2026-03-06

Neoadjuvant CADI-05 in Combination With Pembrolizumab for Surgically Resectable Locally Advanced Head and Neck Squamous Cell Carcinomas

22 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT05919290 2026-03-05

HN-Quest

Phase NA Recruiting

173 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06085781 2026-03-05

HN-BIO

Phase NA Recruiting

60 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06627270 2026-03-05

Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer

30 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Mouth Neoplasms

NCT06868433 2026-03-04

TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer

Phase 1 Recruiting

40 enrolled

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Recurrence

NCT06992427 2026-03-04

HOPE

Phase 3 Recruiting

228 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT05977907 2026-03-03

KIEO

30 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07447570 2026-03-03

Iparomlimab and Tuvonralimab Plus Hypofractionated Radiotherapy and Chemotherapy for HAHNSCC

27 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02031250 2026-03-02

Randomized Phase II Study of DCE-MRI-based Dose Escalation for Poor-prognosis and Neck Cancer

106 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck

NCT05681039 2026-03-02

Phase 2 Trial of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab in Patients With Newly Diagnosed PD-L1 CPS Positive Resectable Stage 3-4 Oral Cavity Squamous Cell Carcinoma (OCSCC).

29 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT07026474 2026-03-02

RePaIr-HN

Phase 3 Recruiting

214 enrolled

Phase 3 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07441681 2026-03-02

Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin

454 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT04290546 2026-02-27

CIML NK Cell in Head & Neck Cancer

Phase 1 Completed

11 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06239220 2026-02-27

PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

25 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05316688 2026-02-25

A Fluorescent Tumor Marking Agent, Tozuleristide, for Imaging Oral Cavity Squamous Cell Cancer and High-Grade Oral Cavity Dysplasia During Surgery

Phase 1/2 Terminated

8 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT06336941 2026-02-25

HOUSTON

Phase NA Recruiting

400 enrolled

Phase 3 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT07432087 2026-02-25

Camrelizumab Combined With EGFR Monoclonal Antibody or Chemotherapy for Perioperative Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma

246 enrolled

Phase 3 Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT01893307 2026-02-24

Intensity-Modulated Proton Beam Therapy or Intensity-Modulated Photon Therapy in Treating Patients With Stage III-IVB Oropharyngeal Cancer

440 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT04305366 2026-02-24

MicroRNA Markers in Head and Neck Cancers

Active not recruiting

225 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06678724 2026-02-24

Establishment of a Microfluidic Based Liquid Biopsy Platform for Recurrent/Metastatic Head and Neck Cancers Prognostication Using NK Cell IFN-γ Expression and CTM Correlation With DS-SACA Chip

Recruiting

30 enrolled

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplastic Cells, Circulating

NCT03174275 2026-02-23

Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma

39 enrolled 8 charts

GastrointestinalHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Esophageal Neoplasms, Laryngeal Neoplasms, Lip Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT07428148 2026-02-23

Lattice-Based Radiotherapy and Chemoimmunotherapy for Oropharyngeal Squamous Cell Carcinoma

Phase 1/2 Not yet recruiting

60 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06855212 2026-02-20

Phase II Study of Neoadjuvant Cetuximab and Cemiplimab in Patients Undergoing Surgery for HNSCC

21 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT03953976 2026-02-19

INRT-AIR: A Prospective Phase II Study of Involved Nodal Radiation Therapy

67 enrolled 16 charts

Squamous Cell Carcinoma of Head and Neck

NCT05674396 2026-02-19

3-5 FrAction Stereotactic Body Radiation Therapy for Palliation of Head and Neck Squamous Cell Carcinoma: the FAST Phase II Randomized Trial

108 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07063212 2026-02-19

A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC)

40 enrolled

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT07419464 2026-02-19

5-Fluorouracil Response and Optimization STudy (The FROST Trial)

46 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Laryngeal Diseases

NCT05268614 2026-02-18

Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell Carcinoma

250 enrolled

Phase NA Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07413627 2026-02-18

BaReTox

70 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Oropharyngeal Neoplasms, Xerostomia

NCT07417605 2026-02-18

POLARIS

Not yet recruiting

180 enrolled

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT07418034 2026-02-18

SAVED

132 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT03480672 2026-02-17

Postoperative aRCH With Cisplatin Versus aRCH With Cisplatin and Pembrolizumab in Locally Advanced Head and Neck Squamous Cell Carcinoma

211 enrolled