Clinical Trials Browser

Completed × OTHER × Squamous Cell Carcinoma of Head and Neck × Clear all

NCT01612351 2026-03-17

Multimodality Risk Adapted Tx Including Induction Chemo for SCCHN Amenable to Transoral Surgery

Phase 2 Completed

40 enrolled 20 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT05120947 2026-03-17

HART-HN

Phase NA Completed

18 enrolled 11 charts

Squamous Cell Carcinoma of Head and Neck

NCT04042935 2026-03-16

Alpha Lipoic Acid to Decrease Pain and Side Effects in Concurrent Treatment of HNSCC

Phase 1 Completed

Squamous Cell Carcinoma of Head and Neck

NCT03313804 2026-03-11

Priming Immunotherapy in Advanced Disease With Radiation

Phase 2 Completed

76 enrolled 9 charts

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung

NCT04696744 2026-03-11

CTCO

Squamous Cell Carcinoma of Head and Neck, Neoplastic Cells, Circulating, Oropharyngeal Neoplasms

NCT03370276 2026-03-10

Cetuximab & Nivolumab in Patients With Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma

Phase 1/2 Completed

95 enrolled 15 charts

Squamous Cell Carcinoma of Head and Neck, Neoplasms, Squamous Cell

NCT02031250 2026-03-02

Randomized Phase II Study of DCE-MRI-based Dose Escalation for Poor-prognosis and Neck Cancer

Phase 2 Completed

106 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck

NCT04290546 2026-02-27

CIML NK Cell in Head & Neck Cancer

Phase 1 Completed

Squamous Cell Carcinoma of Head and Neck

NCT03953976 2026-02-19

INRT-AIR: A Prospective Phase II Study of Involved Nodal Radiation Therapy

Phase 2 Completed

67 enrolled 16 charts

Squamous Cell Carcinoma of Head and Neck

NCT03480672 2026-02-17

Postoperative aRCH With Cisplatin Versus aRCH With Cisplatin and Pembrolizumab in Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase 2 Completed

Squamous Cell Carcinoma of Head and Neck

NCT03993353 2026-02-12

Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer

Phase 2 Completed

7 enrolled 14 charts

GastrointestinalHead & Neck

Pyridoxine-dependent epilepsy, Parkinson Disease 4, Autosomal Dominant Lewy Body, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Esophageal Neoplasms, Head and Neck Neoplasms, Mouth Neoplasms, Neoplasm Metastasis, Neoplasms

NCT01932697 2026-02-10

Radiation Therapy and Docetaxel in Treating Patients With HPV-Related Oropharyngeal Cancer

Phase 2 Completed

81 enrolled 18 charts

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT04284540 2026-02-03

Hypofractionated Radiotherapy in Elderly Patients With Head & Neck Squamous Cell Carcinoma

Phase NA Completed

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07378345 2026-01-30

DigiComSurg

Phase NA Completed

Squamous Cell Carcinoma of Head and Neck, Communication

NCT03082534 2026-01-28

Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma

Phase 2 Completed

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Neoplasm Metastasis, Oropharyngeal Neoplasms, Recurrence

NCT03829722 2026-01-22

Radiotherapy, Carboplatin/Paclitaxel and Nivolumab for High Risk HPV-related Head and Neck Cancer

Phase 2 Completed

26 enrolled 13 charts

Squamous Cell Carcinoma of Head and Neck

NCT02862678 2026-01-21

ORODIFF

Phase NA Completed

Squamous Cell Carcinoma of Head and Neck

NCT04139057 2026-01-20

EBV-Specific Anti-PD1 TCR-T Cells in the Treatment of EBV-Positive NHSCC

Phase 1/2 Completed

Squamous Cell Carcinoma of Head and Neck

NCT07337122 2026-01-13

Collagen Matrix in Oral Cancer Surgery

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT04326257 2026-01-08

Personalized Immunotherapy in Patients With Recurrent /Metastatic SCCHN That Have Progressed on Prior Immunotherapy

Phase 2 Completed

20 enrolled 13 charts

Diabetes Mellitus, Insulin-Dependent, 12, Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis, Recurrence

NCT05482880 2026-01-06

Decisional Conflicts, Health-related QoL and Satisfaction With Care in High-risk cSCC in the Head-neck Region

DermatologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Skin Neoplasms, Patient Satisfaction

NCT03896412 2026-01-02

PERSO-NECK

Phase NA Completed

Squamous Cell Carcinoma of Head and Neck

NCT04031534 2026-01-02

HYPONECK

Phase 2 Completed

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04157985 2025-12-11

Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors

Phase 3 Completed

DermatologicGastrointestinalGenitourinaryGynecologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Anus Neoplasms, Urinary Bladder Neoplasms, Uterine Cervical Neoplasms, Carcinoma, Hepatocellular, Kidney Neoplasms, Melanoma, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Cholangiocarcinoma

NCT03381183 2025-12-05

IRX-2 Regimen and Durvalumab, for Incurable H&N Squamous Cell Carcinoma

Phase 1 Completed

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT06730412 2025-12-04

Clear-HPVca

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Neoplasm, Residual

NCT04725396 2025-11-20

CURVE

Phase NA Completed

Squamous Cell Carcinoma of Head and Neck

NCT04454489 2025-11-19

Quad Shot Radiotherapy in Combination With Immune Checkpoint Inhibition

Phase 2 Completed

21 enrolled 18 charts

Squamous Cell Carcinoma of Head and Neck

NCT02369458 2025-11-18

Mitomycin C in Patients With Incurable p16 Positive Oropharyngeal and p16 Negative Head and Neck Squamous Cell Carcinoma (HNSCC) Resistant to Standard Therapies

Phase 2 Completed

48 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck

NCT03021993 2025-11-12

Trial of Nivolumab as a Novel Neoadjuvant Pre-Surgical Therapy for Locally Advanced Oral Cavity Cancer

Phase 2 Completed

17 enrolled 15 charts

Squamous Cell Carcinoma of Head and Neck

NCT05057247 2025-10-31

Duvelisib Plus Docetaxel In Recurrent/Metastatic HNSCC

Phase 2 Completed

26 enrolled 23 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03049618 2025-10-22

Recombinant EphB4-HSA Fusion Protein and Pembrolizumab, MK-3475

Phase 2 Completed

42 enrolled 40 charts

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung

NCT01644786 2025-10-02

The Head and Neck Tumor Biobank

Squamous Cell Carcinoma of Head and Neck, Laryngeal Diseases

NCT00765440 2025-09-30

Study of Nutrition Regimens in Treating Patients With Cancer of the Upper Aerodigestive Tract

Phase 3 Completed

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Infections, Tongue Neoplasms, Malnutrition

NCT00875849 2025-09-30

AACER

Phase 2 Completed

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Tongue Neoplasms

NCT04694846 2025-09-09

Effectiveness of an Enhanced Tobacco Intervention Protocol Compared to Standard Treatment in Helping Head and Neck and Lung Cancer Patients Starting Treatment to Reduce Cigarette Use

Phase NA Completed

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung

NCT03552965 2025-09-02

Margin-Based Vs. Robust Photon Radiotherapy Planning in IMRT of HN-SQCC

Phase NA Completed

23 enrolled 21 charts

Squamous Cell Carcinoma of Head and Neck, Xerostomia

NCT03623646 2025-08-08

CITHARE

Phase 2 Completed

Squamous Cell Carcinoma of Head and Neck

NCT00665392 2025-08-01

ECHO-07

Phase 2 Completed

42 enrolled 24 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Tongue Neoplasms

NCT05156970 2025-07-31

Camrelizumab in Combination With Chemotherapy or Apatinib Mesylate as First-Line Treatment for R/M HNSCC

Phase 2 Completed

Squamous Cell Carcinoma of Head and Neck

NCT03795610 2025-07-25

IPI-549 in Patients With Locally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma

Phase 2 Completed

16 enrolled 10 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Head and Neck Neoplasms, Neoplasms

NCT03635164 2025-06-27

Radiotherapy With Durvalumab Prior to Surgical Resection for HPV Negative Squamous Cell Carcinoma

Phase 1 Completed

Squamous Cell Carcinoma of Head and Neck

NCT07015333 2025-06-11

Case Review of Patients With Betel Nut-induced Oral Cancer Treated With Pembrolizumab and Cetuximab

Squamous Cell Carcinoma of Head and Neck

NCT05499065 2025-05-31

LIGHTNING

Phase 2 Completed

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06251050 2025-05-30

A Lithium-containing Mouthwash Prevention and Treatment of Oral Mucositis and Dysgeusia in Patients Undergoing Radiotherapy

Phase 1/2 Completed

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Head and Neck Neoplasms, Stomatitis

NCT06757530 2025-05-28

Radiomics Model for Assessing Lymph Node Status in cN0 Patients withHNSCC

Squamous Cell Carcinoma of Head and Neck

NCT03953443 2025-05-22

Expression & Epigenetic Silencing of MicroRNA for Predicting Therapeutic Response and Prognosis of HPV-negative HNSCC

Squamous Cell Carcinoma of Head and Neck

NCT05516589 2025-05-22

neoCHANCE-2

Phase 2 Completed

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04555837 2025-05-20

Alisertib and Pembrolizumab for the Treatment of Patients With Rb-deficient Head and Neck Squamous Cell Cancer

Phase 1/2 Completed

24 enrolled 13 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02245100 2025-05-15

Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung Cancer

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Salivary Gland Neoplasms, Tongue Neoplasms