Clinical Trials

Squamous Cell Carcinoma of Head and Neck

NCT07400094 2026-02-10

NeoCamre-HN

Squamous Cell Carcinoma of Head and Neck, Laryngeal Neoplasms, Mouth Neoplasms

NCT07392580 2026-02-06

Intralesional Chemotherapy (IC): Cisplatin + Epinephrine

20 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07393477 2026-02-06

Neoadjuvant Becotatug Vedotin Plus Pucotenlimab and Cisplatin for Locally Advanced Head and Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma of Head and Neck

NCT07214987 2026-01-30

PDT For Induction Therapy For Head And Neck Cancer

26 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT07379424 2026-01-30

A Single-arm, Phase II, Multi-center Clinical Trial of Sintilimab During the Perioperative Period in Patients With Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma

37 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07335380 2026-01-29

Lattice-Based Radiotherapy and Chemo-Immunotherapy for Oral Cavity Squamous Cell Carcinoma

Squamous Cell Carcinoma of Head and Neck

NCT04266730 2026-01-28

PANDA-VAC

6 enrolled

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Lung Neoplasms

NCT07371897 2026-01-28

SHINE

154 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07361133 2026-01-22

Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell Cancer

120 enrolled

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis, Recurrence

NCT07354984 2026-01-21

PIONEER-HN

Squamous Cell Carcinoma of Head and Neck

NCT07320690 2026-01-06

Neo-Margin

356 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07306546 2025-12-29

Effectiveness of Hydrogen Water Intervention on Acute Oral Inflammation, Oral Microbiota, and Pain Following Free Flap Reconstruction in Patients With Oral Cancer

36 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Pain, Postoperative

NCT07279116 2025-12-12

ABY-029 Head & Neck Trial

24 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07264075 2025-12-04

ILLUMINE

780 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07241273 2025-11-21

SELECT-FR

128 enrolled

Phase 1/2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT07213934 2025-10-15

Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma

40 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07216833 2025-10-15

Decitabine and Nivolumab in Participants With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck

15 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07058805 2025-10-02

COMPORT

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06528353 2025-09-19

SCREEN-HPV

GastrointestinalHead & Neck

10,000 enrolled

Squamous Cell Carcinoma of Head and Neck, Anus Neoplasms, Head and Neck Neoplasms

NCT07168785 2025-09-11

[18F]-AraG PET Imaging in LA HNSCC

Phase EARLY_PHASE1 Not yet recruiting

5 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07137858 2025-08-22

Adebrelimab Combined With Carboplatin and Albumin-bound Taxanol in the Treatment of Resectable Locally Advanced Oral Squamous Cell Carcinoma Cardiac, Randomized, Phase II Exploratory Study

70 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07127614 2025-08-17

Primary Tumor Depth of Invasion and Lymph Node Management in Oral Squamous Cell Carcinoma

Not yet recruiting

25 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT07090707 2025-07-29

PD-1 Inhibitor Therapy Versus Radiotherapy in MPR Patients With Locally Advanced HNSCC After Neoadjuvant Immunochemotherapy (HNC-SYSU-006)

Squamous Cell Carcinoma of Head and Neck

NCT07040072 2025-06-26

LONG'E

10 enrolled

Phase EARLY_PHASE1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07028918 2025-06-19

NCLDR

35 enrolled

Acidemia, isovaleric, Squamous Cell Carcinoma of Head and Neck

NCT06957938 2025-05-08

Comparing Neoadjuvant Chemotherapy Combined With PD-1 Inhibitor Versus Neoadjuvant Chemotherapy in Locally Advanced Laryngeal and Hypopharyngeal Carcinoma

168 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms

NCT06861712 2025-04-25

Chemoimmunotherapy With or Without SBRT Before Surgery for Locally Advanced Oral and Oropharyngeal Cancer

Phase 1/2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT06482307 2025-04-18

[18F]-olaparib

10 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06929468 2025-04-16

Cisplatin-induced Cochlear and Vestibular Damage in Head and Neck Cancer

Not yet recruiting

55 enrolled

Phase 1/2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Ototoxicity, Deafness, Dizziness, Head and Neck Neoplasms, Hearing Loss, Sensorineural, Vestibular Diseases, Hearing Loss

NCT06875791 2025-04-01

TEMOR

40 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Stomatitis

NCT06895369 2025-03-26

The Efficacy and Safety of Pucotenlimab Combined With TP Chemotherapy as Neoadjuvant Therapy for Locally Advanced HNSCC

Squamous Cell Carcinoma of Head and Neck

NCT05835804 2025-03-21

NIVOCHIMLOC

39 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06861036 2025-03-06

HOASIS

Squamous Cell Carcinoma of Head and Neck

NCT05752149 2025-02-26

STELLAR

27 enrolled