Clinical Trials Browser

Not yet recruiting × Squamous Cell Carcinoma of Head and Neck × Clear all

NCT07156227 2026-03-18

Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma

Phase 1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT07471009 2026-03-13

SPAR

Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Neoplasms

NCT07465276 2026-03-11

Neoadjuvant Ficerafusp Alfa With Pembrolizumab in Resectable SCC

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07460765 2026-03-10

Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)

Phase 1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Mouth Neoplasms, Neoplasms, Squamous Cell

NCT07462377 2026-03-10

A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC

Phase 1 Not yet recruiting

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms

NCT07455032 2026-03-06

Neoadjuvant CADI-05 in Combination With Pembrolizumab for Surgically Resectable Locally Advanced Head and Neck Squamous Cell Carcinomas

Phase 1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07441681 2026-03-02

Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin

Phase 3 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT07272642 2026-02-25

DUNP19

Phase 1 Not yet recruiting

BreastGastrointestinalHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT07432087 2026-02-25

Camrelizumab Combined With EGFR Monoclonal Antibody or Chemotherapy for Perioperative Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase 3 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07428148 2026-02-23

Lattice-Based Radiotherapy and Chemoimmunotherapy for Oropharyngeal Squamous Cell Carcinoma

Phase 1/2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07419464 2026-02-19

5-Fluorouracil Response and Optimization STudy (The FROST Trial)

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Laryngeal Diseases

NCT07413627 2026-02-18

BaReTox

Phase NA Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Oropharyngeal Neoplasms, Xerostomia

NCT07417605 2026-02-18

POLARIS

Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT07418034 2026-02-18

SAVED

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT07405086 2026-02-12

Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study

Phase 2 Not yet recruiting

DermatologicGastrointestinalGenitourinaryHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Lung Neoplasms, Melanoma, Neoplasm Metastasis

NCT07408063 2026-02-12

BeeHive

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07172256 2026-02-11

CUE-101with Pembrolizumab for LA-HPV+HNSCCs

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07400094 2026-02-10

NeoCamre-HN

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Laryngeal Neoplasms, Mouth Neoplasms

NCT07392580 2026-02-06

Intralesional Chemotherapy (IC): Cisplatin + Epinephrine

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07393477 2026-02-06

Neoadjuvant Becotatug Vedotin Plus Pucotenlimab and Cisplatin for Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07214987 2026-01-30

PDT For Induction Therapy For Head And Neck Cancer

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT07379424 2026-01-30

A Single-arm, Phase II, Multi-center Clinical Trial of Sintilimab During the Perioperative Period in Patients With Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07335380 2026-01-29

Lattice-Based Radiotherapy and Chemo-Immunotherapy for Oral Cavity Squamous Cell Carcinoma

Phase 1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT04266730 2026-01-28

PANDA-VAC

Phase 1 Not yet recruiting

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Lung Neoplasms

NCT07371897 2026-01-28

SHINE

Phase 3 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07358884 2026-01-22

First in Human Study of QLS5316 in Solid Tumors

Phase 1 Not yet recruiting

GastrointestinalHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Stomach Neoplasms, Colorectal Neoplasms

NCT07361133 2026-01-22

Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell Cancer

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis, Recurrence

NCT07354984 2026-01-21

PIONEER-HN

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07339176 2026-01-14

OP-NEU-101

Phase 1/2 Not yet recruiting

BreastDermatologicHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Triple Negative Breast Neoplasms

NCT07149207 2026-01-07

Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors

Phase 2 Not yet recruiting

Margins of Excision, Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms

NCT07320690 2026-01-06

Neo-Margin

Phase 3 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07306546 2025-12-29

Effectiveness of Hydrogen Water Intervention on Acute Oral Inflammation, Oral Microbiota, and Pain Following Free Flap Reconstruction in Patients With Oral Cancer

Phase NA Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Pain, Postoperative

NCT06769698 2025-12-16

A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis, Recurrence

NCT07279116 2025-12-12

ABY-029 Head & Neck Trial

Phase 1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07264075 2025-12-04

ILLUMINE

Phase 3 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07246759 2025-11-24

NEUTROFLOW

Not yet recruiting

BreastDermatologicGenitourinaryHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Melanoma, Triple Negative Breast Neoplasms

NCT07241273 2025-11-21

SELECT-FR

Phase NA Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT07213934 2025-10-15

Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma

Phase 1/2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07216833 2025-10-15

Decitabine and Nivolumab in Participants With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck

Phase 1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07058805 2025-10-02

COMPORT

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06528353 2025-09-19

SCREEN-HPV

Phase NA Not yet recruiting

10,000 enrolled

GastrointestinalHead & Neck

Squamous Cell Carcinoma of Head and Neck, Anus Neoplasms, Head and Neck Neoplasms

NCT07168785 2025-09-11

[18F]-AraG PET Imaging in LA HNSCC

Phase EARLY_PHASE1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07137858 2025-08-22

Adebrelimab Combined With Carboplatin and Albumin-bound Taxanol in the Treatment of Resectable Locally Advanced Oral Squamous Cell Carcinoma Cardiac, Randomized, Phase II Exploratory Study

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07127614 2025-08-17

Primary Tumor Depth of Invasion and Lymph Node Management in Oral Squamous Cell Carcinoma

Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT07090707 2025-07-29

PD-1 Inhibitor Therapy Versus Radiotherapy in MPR Patients With Locally Advanced HNSCC After Neoadjuvant Immunochemotherapy (HNC-SYSU-006)

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07040072 2025-06-26

LONG'E

Phase 1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07036185 2025-06-25

A Clinical Trail of KJ015 in Patients With HER2-Expressing Solid Tumors

Phase 1 Not yet recruiting

BreastGastrointestinalHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Bile Duct Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms

NCT07028918 2025-06-19

NCLDR

Phase EARLY_PHASE1 Not yet recruiting

Acidemia, isovaleric, Squamous Cell Carcinoma of Head and Neck

NCT06957938 2025-05-08

Comparing Neoadjuvant Chemotherapy Combined With PD-1 Inhibitor Versus Neoadjuvant Chemotherapy in Locally Advanced Laryngeal and Hypopharyngeal Carcinoma

Phase 3 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms

NCT06861712 2025-04-25

Chemoimmunotherapy With or Without SBRT Before Surgery for Locally Advanced Oral and Oropharyngeal Cancer

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck