Clinical Trials Browser

Interventional × Tuberous Sclerosis × 1 year × Clear all

Mental Disorders, Tuberous Sclerosis

NCT05044819 2026-03-17

Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution

Phase 4 Active not recruiting

154 enrolled

Epilepsies, Myoclonic, Liver Cirrhosis, Tuberous Sclerosis, Lennox Gastaut Syndrome

NCT05864846 2026-03-12

EpiCom

Phase 4 Active not recruiting

79 enrolled

Behavior, Seizures, Tuberous Sclerosis

NCT07403266 2026-02-11

Spectrum

Phase 3 Recruiting

84 enrolled

Tuberous Sclerosis

NCT02962414 2026-02-03

Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment

Phase 3 Active not recruiting

206 enrolled

Seizures, Tuberous Sclerosis

NCT05252585 2026-02-03

A Phase IV Study of Safety and Efficacy of Everolimus in Taiwanese Patients With Tuberous Sclerosis Complex Who Have Renal Angiomyolipoma (TSC-AML)

Phase 4 Active not recruiting

4 enrolled

Tuberous Sclerosis, Angiomyolipoma

NCT07369505 2026-01-27

Sapu003 in Advanced mTOR-sensitive Solid Tumors

Phase 1 Recruiting

27 enrolled

EndocrineGastrointestinalGenitourinaryNET

Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Tuberous Sclerosis, Neuroendocrine Tumors

NCT05104983 2026-01-22

TSC-STEPS

Phase 2 Recruiting

64 enrolled

Epilepsy, Tuberous Sclerosis

NCT05467397 2026-01-21

Feasibility of [11C]Acetate-PET in LAM and TSC

Phase 1/2 Active not recruiting

7 enrolled 6 charts

Tuberous Sclerosis, Lymphangioleiomyomatosis

NCT07287202 2025-12-23

Safety, Tolerability, and Pharmacokinetics of SVG103 (Paxalisib) in Focal Cortical Dysplasia Type II (FCD-II), Tuberous Sclerosis Complex (TSC) or Hemimegalencephaly (HME)

Phase 1/2 Not yet recruiting

15 enrolled

Focal Cortical Dysplasia, Tuberous Sclerosis, Hemimegalencephaly

NCT05626634 2025-12-03

Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopathy

Phase 2 Completed

41 enrolled

CDKL5 deficiency disorder, Epilepsy, Epilepsies, Myoclonic, Tuberous Sclerosis, Lennox Gastaut Syndrome

NCT03363763 2025-12-01

Topical Sirolimus Ointment for Cutaneous Angiofibromas in Subjects With Tuberous Sclerosis Complex

Phase 2 Terminated

24 enrolled 11 charts

Erythema, Exanthema, Fibroma, Tuberous Sclerosis, Facies

NCT06965881 2025-11-21

Study to Evaluate the Pharmacokinetics and Safety Effects Following Coadministration of Carbamazepine or Itraconazole With Radiprodil in Healthy Adults

Phase 1 Terminated

30 enrolled

Focal Cortical Dysplasia, Tuberous Sclerosis

NCT06975605 2025-11-18

Phase 1, Open-label, Drug-drug Interaction Study to Assess Effect Between Radiprodil and the Co-administered Drugs.

Phase 1 Completed

18 enrolled

Focal Cortical Dysplasia, Tuberous Sclerosis

NCT05604170 2025-10-01

Open-label Study of Adjunctive GNX Treatment in Children and Adults With TSC-related Epilepsy

Phase 3 Terminated

117 enrolled 11 charts

Tuberous Sclerosis

NCT06879665 2025-09-22

TANDem-2

Phase NA Enrolling by invitation

30 enrolled

Tuberous Sclerosis

NCT05323734 2025-07-11

Adjunctive GNX Treatment Compared With Placebo in Children and Adults With TSC-related Epilepsy

Phase 3 Completed

129 enrolled 13 charts

Tuberous Sclerosis

NCT06392009 2025-07-03

Astroscape: A Study of Radiprodil on Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavioral Symptoms in Patients With TSC or FCD Type II

Phase 1/2 Recruiting

30 enrolled

Focal Cortical Dysplasia, Tuberous Sclerosis

NCT05059327 2025-06-04

Basimglurant (NOE-101) in Children, Adolescents, and Young Adults With TSC

Phase 2 Completed

61 enrolled

Seizures, Tuberous Sclerosis

Clinical Trials

RAINBOW

Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution

EpiCom

Spectrum

Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment

A Phase IV Study of Safety and Efficacy of Everolimus in Taiwanese Patients With Tuberous Sclerosis Complex Who Have Renal Angiomyolipoma (TSC-AML)

Sapu003 in Advanced mTOR-sensitive Solid Tumors

TSC-STEPS

Feasibility of [11C]Acetate-PET in LAM and TSC

Safety, Tolerability, and Pharmacokinetics of SVG103 (Paxalisib) in Focal Cortical Dysplasia Type II (FCD-II), Tuberous Sclerosis Complex (TSC) or Hemimegalencephaly (HME)

Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopathy

Topical Sirolimus Ointment for Cutaneous Angiofibromas in Subjects With Tuberous Sclerosis Complex

Study to Evaluate the Pharmacokinetics and Safety Effects Following Coadministration of Carbamazepine or Itraconazole With Radiprodil in Healthy Adults

Phase 1, Open-label, Drug-drug Interaction Study to Assess Effect Between Radiprodil and the Co-administered Drugs.

Open-label Study of Adjunctive GNX Treatment in Children and Adults With TSC-related Epilepsy

TANDem-2

Adjunctive GNX Treatment Compared With Placebo in Children and Adults With TSC-related Epilepsy

Astroscape: A Study of Radiprodil on Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavioral Symptoms in Patients With TSC or FCD Type II

Basimglurant (NOE-101) in Children, Adolescents, and Young Adults With TSC