Clinical Trials Browser

Nephronophthisis, familial juvenile, Treatment Adherence and Compliance, Albuminuria, Diabetes Mellitus, Hypertension, Polycystic Kidney Diseases, Tuberous Sclerosis, Renal Insufficiency, Chronic, Kidney Diseases, Cystic

NCT04698538 2024-10-30

TRAIN

Phase NA Completed

54 enrolled

Tuberous Sclerosis

NCT02849457 2024-08-19

Preventing Epilepsy Using Vigabatrin In Infants With Tuberous Sclerosis Complex

Phase 2 Completed

84 enrolled 16 charts

Tuberous Sclerosis

NCT04595513 2024-05-16

STOP2

Phase 1/2 Completed

5 enrolled 15 charts

Epilepsy, Tuberous Sclerosis

NCT01906866 2024-04-23

Efficacy and Safety of Circadin® in the Treatment of Sleep Disturbances in Children With Neurodevelopment Disabilities

Phase 3 Completed

125 enrolled 22 charts

Autism Spectrum Disorder, Sleep Wake Disorders, Tuberous Sclerosis, Angelman Syndrome, Parasomnias, Smith-Magenis Syndrome

NCT05867576 2024-02-14

ACT in TSC

Phase NA Unknown

15 enrolled

Psychological Well-Being, Tuberous Sclerosis

NCT04987463 2024-02-08

ViRap

Phase 2/3 Recruiting

60 enrolled

Epilepsy, Neoplasms, Tuberous Sclerosis

NCT04344626 2023-10-10

Use of a Tonometer to Identify Epileptogenic Lesions During Pediatric Epilepsy Surgery

Phase NA Withdrawn

CNS

Focal Cortical Dysplasia, Brain Neoplasms, Encephalitis, Epilepsy, Gliosis, Sturge-Weber Syndrome, Tuberous Sclerosis, Stroke, Hemimegalencephaly, Polymicrogyria

NCT03826628 2023-09-08

Dose-Ranging Efficacy and Safety Study of Topical Rapamycin Cream for Facial Angiofibroma Associated With Tuberous Sclerosis Complex

Phase 2/3 Completed

107 enrolled 24 charts

Tuberous Sclerosis

NCT05534672 2023-08-08

RaRE-TS

Phase 3 Recruiting

200 enrolled

Drug Resistant Epilepsy, Epilepsy, Tuberous Sclerosis

NCT04285346 2023-04-04

TSC

Phase 2 Completed

23 enrolled 9 charts

Tuberous Sclerosis

NCT02544750 2022-07-14

An Open-label Extension Trial of Cannabidiol (GWP42003-P, CBD) for Seizures in Tuberous Sclerosis Complex (GWPCARE6)

Phase 3 Completed

199 enrolled 14 charts

Seizures, Tuberous Sclerosis

NCT03525834 2021-09-09

Safety and Efficacy of Everolimus (Afinitor®) in Chinese Adult Patients With Angiomyolipoma Associated With Tuberous Sclerosis Complex.

Phase 4 Completed

40 enrolled 10 charts

Tuberous Sclerosis, Lymphangioleiomyomatosis, Angiomyolipoma

NCT02451696 2021-09-01

A Pilot Study To Evaluate The Effects of Everolimus on Brain mTOR Activity and Cortical Hyperexcitability in TSC and FCD

Phase 2 Completed

15 enrolled 9 charts

Focal Cortical Dysplasia, Epilepsy, Tuberous Sclerosis

NCT02860494 2021-05-03

EVEROST

Phase 2/3 Withdrawn

Tuberous Sclerosis

NCT01929642 2021-03-29

RAPT

Phase 2 Completed

3 enrolled 10 charts

Autistic Disorder, Tuberous Sclerosis, Self-Injurious Behavior

NCT03650452 2021-02-18

ELEKTRA

Phase 2 Completed

141 enrolled 24 charts

CNS

CDKL5 deficiency disorder, Brain Diseases, Central Nervous System Diseases, Epilepsy, Epilepsies, Myoclonic, Nervous System Diseases, Seizures, Spasms, Infantile, Tuberous Sclerosis, Hypoxia-Ischemia, Brain, Malformations of Cortical Development, Lennox Gastaut Syndrome

NCT03422367 2020-11-06

JETS

Phase NA Unknown

64 enrolled

Autistic Disorder, Child Development Disorders, Pervasive, Epilepsy, Tuberous Sclerosis

NCT01526356 2020-10-26

Treatment

Phase 2 Completed

179 enrolled 13 charts

Tuberous Sclerosis, Angiofibroma

NCT02201212 2020-09-16

Everolimus for Cancer With TSC1 or TSC2 Mutation

Phase 2 Completed

30 enrolled 12 charts

Tuberous Sclerosis

NCT02061397 2020-08-25

SOS

Phase 1/2 Completed

10 enrolled 6 charts

Tuberous Sclerosis, Lymphangioleiomyomatosis

NCT03356769 2020-06-09

Aspirin as an add-on Treatment of Refractory Epilepsy in Tuberous Sclerosis Complex

Phase 2 Unknown

98 enrolled

Epilepsy, Seizures, Tuberous Sclerosis, Cognitive Dysfunction

NCT02634931 2019-02-20

Long-term Trial of Topical Sirolimus to Angiofibroma in Patient With Tuberous Sclerosis Complex

Phase 3 Completed

94 enrolled

Tuberous Sclerosis, Angiofibroma, Plaque, Amyloid

NCT03326765 2018-10-17

Characterizing Sleep Disorders in Children and Adults With Tuberous Sclerosis Complex (TSC)

Phase NA Unknown

60 enrolled

Sleep Wake Disorders, Tuberous Sclerosis

NCT02687633 2018-05-02

Early Behavioral Intervention to Improve Social Communication Function in Infants With Tuberous Sclerosis Complex

Phase NA Completed

8 enrolled

Tuberous Sclerosis

NCT03254680 2018-04-30

Turmeric as Treatment in Epilepsy

Phase NA Withdrawn

Epilepsy, Epilepsies, Myoclonic, Seizures, Tuberous Sclerosis, Lennox Gastaut Syndrome

NCT01289912 2018-01-25

TSC

Phase 2 Completed

52 enrolled 12 charts

Autistic Disorder, Tuberous Sclerosis

NCT02104011 2018-01-23

STBETA

Phase 2 Completed

2 enrolled

Tuberous Sclerosis

NCT03140449 2017-05-04

Topical Rapamycin and Calcitriol for Angiofibroma of Tuberous Sclerosis

Phase 3 Completed

52 enrolled

Tuberous Sclerosis

NCT01070316 2017-03-13

Everolimus (RAD001) Therapy for Epilepsy in Patients With Tuberous Sclerosis Complex (TSC)

Phase 1/2 Completed

20 enrolled 8 charts

Epilepsy, Hereditary Sensory and Autonomic Neuropathies, Tuberous Sclerosis

Clinical Trials

RAINBOW

Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution

EpiCom

Spectrum

Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment

A Phase IV Study of Safety and Efficacy of Everolimus in Taiwanese Patients With Tuberous Sclerosis Complex Who Have Renal Angiomyolipoma (TSC-AML)

Sapu003 in Advanced mTOR-sensitive Solid Tumors

TSC-STEPS

Feasibility of [11C]Acetate-PET in LAM and TSC

Safety, Tolerability, and Pharmacokinetics of SVG103 (Paxalisib) in Focal Cortical Dysplasia Type II (FCD-II), Tuberous Sclerosis Complex (TSC) or Hemimegalencephaly (HME)

Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopathy

Topical Sirolimus Ointment for Cutaneous Angiofibromas in Subjects With Tuberous Sclerosis Complex

Study to Evaluate the Pharmacokinetics and Safety Effects Following Coadministration of Carbamazepine or Itraconazole With Radiprodil in Healthy Adults

Phase 1, Open-label, Drug-drug Interaction Study to Assess Effect Between Radiprodil and the Co-administered Drugs.

Open-label Study of Adjunctive GNX Treatment in Children and Adults With TSC-related Epilepsy

TANDem-2

Adjunctive GNX Treatment Compared With Placebo in Children and Adults With TSC-related Epilepsy

Astroscape: A Study of Radiprodil on Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavioral Symptoms in Patients With TSC or FCD Type II

Basimglurant (NOE-101) in Children, Adolescents, and Young Adults With TSC

Clinical Study of NPC-12Y Gel in Patients With Skin Lesions Associated With TSC

KidneYou - Innovative Digital Therapy

TRAIN

Preventing Epilepsy Using Vigabatrin In Infants With Tuberous Sclerosis Complex

STOP2

Efficacy and Safety of Circadin® in the Treatment of Sleep Disturbances in Children With Neurodevelopment Disabilities

ACT in TSC

ViRap

Use of a Tonometer to Identify Epileptogenic Lesions During Pediatric Epilepsy Surgery

Dose-Ranging Efficacy and Safety Study of Topical Rapamycin Cream for Facial Angiofibroma Associated With Tuberous Sclerosis Complex

RaRE-TS

TSC

An Open-label Extension Trial of Cannabidiol (GWP42003-P, CBD) for Seizures in Tuberous Sclerosis Complex (GWPCARE6)

Safety and Efficacy of Everolimus (Afinitor®) in Chinese Adult Patients With Angiomyolipoma Associated With Tuberous Sclerosis Complex.

A Pilot Study To Evaluate The Effects of Everolimus on Brain mTOR Activity and Cortical Hyperexcitability in TSC and FCD

EVEROST

RAPT

ELEKTRA

JETS

Treatment

Everolimus for Cancer With TSC1 or TSC2 Mutation

SOS

Aspirin as an add-on Treatment of Refractory Epilepsy in Tuberous Sclerosis Complex

Long-term Trial of Topical Sirolimus to Angiofibroma in Patient With Tuberous Sclerosis Complex

Characterizing Sleep Disorders in Children and Adults With Tuberous Sclerosis Complex (TSC)

Early Behavioral Intervention to Improve Social Communication Function in Infants With Tuberous Sclerosis Complex

Turmeric as Treatment in Epilepsy

TSC

STBETA

Topical Rapamycin and Calcitriol for Angiofibroma of Tuberous Sclerosis

Everolimus (RAD001) Therapy for Epilepsy in Patients With Tuberous Sclerosis Complex (TSC)