Clinical Trials

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Oropharyngeal Neoplasms, Xerostomia

NCT05106608 2026-01-05

LAXER

60 enrolled

Head and Neck Neoplasms, Neoplasms, Xerostomia

NCT00540774 2025-12-18

Optical Sensor for Photodynamic Detection of Oral Pathology

Phase NA Suspended

2,500 enrolled

Phase 2 Not yet recruiting

Gingivitis, Mouth Diseases, Mouth Neoplasms, Periodontitis, Stomatitis, Xerostomia

NCT07290946 2025-12-18

MESRIX-more

100 enrolled

Phase 3 Active not recruiting

Head and Neck Neoplasms, Sjogren's Syndrome, Xerostomia

NCT01266044 2025-10-27

Controlled Trial Of Acupuncture To Prevent Radiation-Induced Xerostomia

435 enrolled

Phase 1 Active not recruiting

Head and Neck Neoplasms, Oropharyngeal Neoplasms, Xerostomia

NCT05859711 2025-09-29

Effectiveness of Thyme Honey in Management of Xerostomia in Post Radiation Cancer Patients

Phase 4 Completed

90 enrolled

Xerostomia

NCT02446249 2025-09-25

Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction

17 enrolled

Phase EARLY_PHASE1 Completed

Head and Neck Neoplasms, Xerostomia

NCT05403125 2025-09-17

SDF Application in Oral Cancer Patients to Prevent Dental Caries

56 enrolled

Dental Caries, Pharyngeal Neoplasms, Xerostomia

NCT04805528 2025-09-11

Study of Non-invasive Acupuncture-like Transcutaneous Electrical Nerve Stimulation (Altens) to Help Alleviate Xerostomia After Radiation Therapy for Cancers of the Head and Neck

75 enrolled

Head and Neck Neoplasms, Xerostomia

NCT06276946 2025-09-05

Sparing Parotid Ducts Via MRI Sialography for Reduced Patient Reported Xerostomia

Phase NA Withdrawn

Head and Neck Neoplasms, Oropharyngeal Neoplasms, Xerostomia

NCT03552965 2025-09-02

Margin-Based Vs. Robust Photon Radiotherapy Planning in IMRT of HN-SQCC

23 enrolled 21 charts

Squamous Cell Carcinoma of Head and Neck, Xerostomia

NCT06465628 2025-05-28

Acupressure on Xerostomia in Head and Neck Cancer Patients

126 enrolled

Head and Neck Neoplasms, Xerostomia

NCT06122636 2025-04-03

HNC

62 enrolled

Dental Plaque, Head and Neck Neoplasms, Periodontal Diseases, Stomatitis, Xerostomia, Dysbiosis

NCT04222478 2025-02-12

AURICULOXERO

Phase NA Not yet recruiting

68 enrolled

Xerostomia

NCT05872464 2024-06-24

Artificial Saliva Containing Cumin and Ginger Extract in Head and Neck Cancer Patients With Xerostomia

52 enrolled

Xerostomia

NCT06413550 2024-05-14

The Efficacy of Hibiscus Sabdariffa in Xerostomia

40 enrolled

Xerostomia

NCT04608773 2024-02-01

Blinded Dry Mouth Spray Crossover Study

129 enrolled 12 charts

Head and Neck Neoplasms, Xerostomia

NCT04717765 2023-11-29

Photobiomodulation in Oral Lesions Resulting From Anti-neoplastic Prevention

60 enrolled

Head and Neck Neoplasms, Mouth Neoplasms, Osteoradionecrosis, Stomatitis, Xerostomia, Bisphosphonate-Associated Osteonecrosis of the Jaw

NCT05614843 2023-10-10

Photobiomodulation Therapy in Patients With Head and Neck Cancer Post-Radiotherapy

32 enrolled

Head and Neck Neoplasms, Neoplasms, Xerostomia

NCT05242991 2023-03-09

Effectiveness of Photobiomodulation Protocols in Radiation-induced Oral Side Effects in H&N Cancer Patients

132 enrolled

Head and Neck Neoplasms, Taste Disorders, Trismus, Xerostomia, Mucositis

NCT05759975 2023-03-08

Effectiveness of Extraoral Photobiomodulation in Management of Oral Adverse Effects in Patients Undergoing HSCT

Other hematologic neoplasm

42 enrolled

Stomatitis, Xerostomia, Hematologic Neoplasms

NCT02513238 2022-12-28

MESRIX

Phase 2 Completed

30 enrolled 5 charts

Xerostomia

NCT00595933 2022-09-07

Comparing Over-the-counter Dry Mouth Remedies After Radiation

Phase 1 Completed

28 enrolled

Head and Neck Neoplasms, Xerostomia

NCT02292368 2022-09-01

Neurological Effects of Acupuncture to Prevent Radiation-induced Xerostomia

30 enrolled

Head and Neck Neoplasms, Nasopharyngeal Neoplasms, Xerostomia

NCT02474095 2022-07-25

Acupuncture-Like Transcutaneous Electrical Nerve Stimulation in Treating Radiation-Induced Xerostomia in Patients With Head and Neck Cancer

30 enrolled

Xerostomia

NCT04880148 2021-12-09

HONEY

200 enrolled

Head and Neck Neoplasms, Radiation Injuries, Stomatitis, Xerostomia

NCT02941276 2021-11-03

LEONIDAS-2

84 enrolled

Head and Neck Neoplasms, Xerostomia

NCT04738227 2021-07-30

Effect of Low-level Laser Therapy on Salivary Flow, pH and Quality of Life in Irradiated Oropharyngeal Cancer Patients

34 enrolled

Xerostomia

NCT01874587 2021-07-27

ARTIX

Phase 3 Completed

132 enrolled

Oropharyngeal Neoplasms, Xerostomia

NCT00430378 2021-06-10

Acupuncture for Prevention of Radiation-Induced Xerostomia

100 enrolled

Nasopharyngeal Neoplasms, Xerostomia

NCT04007081 2021-03-24

Salivary Gland Autotransplantation for Treatment of XRT Induced Xerostomia

12 enrolled

Head and Neck Neoplasms, Xerostomia

NCT03874572 2021-01-29

MESRIX-SAFETY

Phase 1 Unknown

10 enrolled

Oropharyngeal Neoplasms, Salivary Gland Diseases, Xerostomia

NCT04700475 2021-01-08

Effect of Low Level Laser Therapy on Prevention of Radiotherapy Induced Xerostomia in Cancer Patients.

60 enrolled

Head and Neck Neoplasms, Xerostomia

NCT00862550 2020-12-30

Xerostomia Pilot Fudan: Acupuncture for Prevention of Radiation-Induced Xerostomia

23 enrolled

Nasopharyngeal Carcinoma, Head and Neck Neoplasms, Xerostomia

NCT03151889 2020-08-12

TENS_HIR

67 enrolled

Head and Neck Neoplasms, Xerostomia

NCT04491435 2020-07-29

Saliva Substitute Mouthwash in NPC Survivors With Xerostomia: A Randomized Controlled Trial

94 enrolled

Phase EARLY_PHASE1 Terminated

Nasopharyngeal Neoplasms, Xerostomia

NCT03601962 2020-01-27

Effects of Aqualief® in Patients With Xerostomia as Consequence of Radiotherapy for Head and Neck Cancer

Phase NA Terminated

100 enrolled

Xerostomia

NCT03578432 2019-12-02

Everolimus in Restoring Salivary Gland Function in Participants With Locally Advanced Head and Neck Cancer Treated With Radiation Therapy

2 enrolled

Head and Neck Neoplasms, Mouth Neoplasms, Xerostomia

NCT00656513 2019-11-19

Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer

Phase 2/3 Completed

196 enrolled 13 charts

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Salivary Gland Neoplasms, Tongue Neoplasms, Xerostomia

NCT03302676 2019-03-14

The Use of Chewing Gum for Xerostomia and Hyposalivation After Radiotherapy for Oral and Oropharyngeal Tumors

109 enrolled

Head and Neck Neoplasms, Xerostomia

NCT03035825 2019-02-08

Efficacy of Oral Moisturizing Jelly on Oral Health and Nutrition in Post-radiotherapy Head and Neck Cancer Patients

73 enrolled

Head and Neck Neoplasms, Xerostomia

NCT00068237 2019-02-05

Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer

Phase 2 Completed

49 enrolled 13 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Radiation Injuries, Xerostomia

NCT00372320 2018-09-11

Effect of AdhAQP1 on Salivary Flow in Patients Treated With Radiation for Head and Neck Cancer

Phase 1 Completed

17 enrolled

Adenoviridae Infections, Head and Neck Neoplasms, Xerostomia

NCT00352118 2017-12-28

Combination Chemotherapy and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Cancer

Phase 2 Terminated

4 enrolled 4 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Xerostomia, Mucositis

NCT01762514 2017-07-13

A Phase II Clinical Trial on Comparison of Effectiveness and Safeness of Different Amifostine Regimens

Phase 2 Unknown

360 enrolled

Nasopharyngeal Carcinoma, Bone Marrow Diseases, Nasopharyngeal Neoplasms, Salivary Gland Diseases, Xerostomia, Mucositis

NCT00503776 2017-06-20

Chemo/XRT +/- Amifostine to Assess Outcomes Related to Xerostomia, Mucositis, & Dysphagia

Phase 2 Terminated

41 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck, Deglutition Disorders, Head and Neck Neoplasms, Radiation Injuries, Salivary Gland Neoplasms, Xerostomia, Mucositis

NCT02687087 2017-02-20

A Study of Patients With Dry Mouth and Sticky Saliva During Radiotherapy

44 enrolled

Xerostomia

NCT00095927 2017-01-04

Randomized Amifostine For SCCHN

Phase 2 Completed

58 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Radiation Injuries, Xerostomia, Mucositis

NCT00101582 2016-09-27

Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer

Phase 3 Completed

188 enrolled 19 charts