Clinical Trials Browser

Phase 1 × Metformin × 1 year × Clear all

NCT07372625 2026-03-12

A Study to Investigate the Effects of Multiple Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation.

Phase 1 Recruiting

Other solid neoplasm

TP53 Y220C Mutation

NCT03006172 2026-03-11

To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer

Phase 1 Active not recruiting

Breast Neoplasms

NCT07459595 2026-03-10

Metformin Versus Myo-inositol in the Management of Polycystic Ovarian Disease: A Comparative Study

Phase 1 Not yet recruiting

Polycystic Ovary Syndrome

NCT06899061 2026-03-03

Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saruparib

Phase 1 Active not recruiting

Advanced Solid Malignancies

NCT07399535 2026-02-10

PCOS

Phase 1 Recruiting

Infertility, Metabolic Diseases, Polycystic Ovary Syndrome

NCT02336087 2026-02-04

Gemcitabine Hydrochloride, Paclitaxel Albumin-Stabilized Nanoparticle Formulation, Metformin Hydrochloride, and a Standardized Dietary Supplement in Treating Patients With Pancreatic Cancer That Cannot be Removed by Surgery

Phase 1 Active not recruiting

Gastrointestinal

Pancreatic Adenocarcinoma

NCT06044025 2026-01-15

A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy

Phase 1 Recruiting

Castration Sensitive Prostate Cancer

NCT07098299 2025-11-06

Metformin Combined With Chemotherapy and/or Immunotherapy in Solid Malignancies

Phase 1 Recruiting

Other solid neoplasm

Advanced Solid Tumor

NCT03889795 2025-10-20

Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors

Phase 1 Active not recruiting

GastrointestinalOther solid neoplasm

Advanced Pancreatic Cancer

NCT05536037 2025-05-15

Metformin for the Prevention of Oral Cancer in Patients With Oral Premalignant Lesions

Phase 1 Terminated

Erythroplasia, Leukoplakia, Mouth Neoplasms

NCT01430351 2025-05-07

Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy

Phase 1 Terminated

Glioblastoma, Gliosarcoma

NCT03311308 2025-05-06

A Trial of Pembrolizumab and Metformin Versus Pembrolizumab Alone in Advanced Melanoma

Phase 1 Recruiting

Melanoma

NCT02339168 2025-05-01

Enzalutamide and Metformin Hydrochloride in Treating Patients With Hormone-Resistant Prostate Cancer

Phase 1 Completed

Prostatic Neoplasms

NCT05828303 2025-04-01

A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in Patients With Advanced Solid Tumors

Phase 1 Withdrawn

Neoplasm Metastasis

NCT01529593 2025-03-24

Temsirolimus in Combination With Metformin in Patients With Advanced Cancers

Phase 1 Terminated

Neoplasm Metastasis