Clinical Trials Browser

Erythroplasia, Hyperplasia, Leukoplakia, Oral, Mouth Neoplasms

NCT02437656 2026-03-16

METCAP

Phase 2 Completed

60 enrolled

Gastrointestinal

Rectal Neoplasms

NCT03424005 2026-03-16

Morpheus-panBC

Phase 1/2 Recruiting

792 enrolled

Breast

Breast Neoplasms

NCT07226453 2026-03-13

PNOC041

Phase 2 Recruiting

30 enrolled

Posterior Fossa Ependymal Tumor

NCT07372625 2026-03-12

A Study to Investigate the Effects of Multiple Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation.

Phase 1 Recruiting

14 enrolled

Other solid neoplasm

TP53 Y220C Mutation

NCT03006172 2026-03-11

To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer

Phase 1 Active not recruiting

200 enrolled

Breast

Breast Neoplasms

NCT07459595 2026-03-10

Metformin Versus Myo-inositol in the Management of Polycystic Ovarian Disease: A Comparative Study

Phase 1 Not yet recruiting

60 enrolled

Polycystic Ovary Syndrome

NCT05965908 2026-03-06

Effect of Liraglutide in Obese Women With Polycystic Ovary Syndrome

Phase 3 Completed

150 enrolled

Polycystic Ovary Syndrome

NCT02946996 2026-03-05

Study of Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients Receiving Androgen Deprivation Therapy

Phase 2 Terminated

41 enrolled 8 charts

Genitourinary

Prostatic Neoplasms

NCT07291297 2026-03-05

Metformin Hydrochloride in Combination With Standard of Care Systemic Therapy in Previously Untreated Advanced Unresectable or Metastatic Soft Tissue Sarcoma

Phase 2 Recruiting

50 enrolled

Sarcoma

NCT06899061 2026-03-03

Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saruparib

Phase 1 Active not recruiting

41 enrolled

Advanced Solid Malignancies

NCT03905941 2026-02-23

SHK002

Phase EARLY_PHASE1 Withdrawn

Polycystic Ovary Syndrome

NCT07399535 2026-02-10

PCOS

Phase 1 Recruiting

116 enrolled

Infertility, Metabolic Diseases, Polycystic Ovary Syndrome

NCT04850846 2026-02-09

Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma

Phase 2 Active not recruiting

60 enrolled 10 charts

Plasma cell

Smoldering Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance

NCT05767515 2026-02-09

PCOS

Phase NA Completed

120 enrolled

Infertility, Female, Polycystic Ovary Syndrome

NCT07387900 2026-02-06

Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia

Phase 2 Recruiting

34 enrolled

Head & Neck

Leukoplakia, Oral

NCT02336087 2026-02-04

Gemcitabine Hydrochloride, Paclitaxel Albumin-Stabilized Nanoparticle Formulation, Metformin Hydrochloride, and a Standardized Dietary Supplement in Treating Patients With Pancreatic Cancer That Cannot be Removed by Surgery

Phase 1 Active not recruiting

21 enrolled

Gastrointestinal

Pancreatic Adenocarcinoma

NCT07387679 2026-02-04

Myo-inositol Versus Metformin in Patients With Polycystic Ovarian Syndrome to Treat Obesity

Phase NA Completed

60 enrolled

Polycystic Ovary Syndrome

NCT07380841 2026-02-02

PCOS-COMBO (9)

Phase NA Completed

192 enrolled

Insulin Resistance, Polycystic Ovary Syndrome, Weight Loss, Metabolic Syndrome

NCT02365597 2026-01-30

An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer

Phase 2 Active not recruiting

239 enrolled 32 charts 1 FDA

Genitourinary

Urothelial Cancer

NCT06763328 2026-01-22

Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy

Phase 3 Recruiting

200 enrolled

Breast

Anatomic Stage I Breast Cancer AJCC v8

NCT06044025 2026-01-15

A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy

Phase 1 Recruiting

34 enrolled

Genitourinary

Castration Sensitive Prostate Cancer

NCT07323589 2026-01-07

Impact of Myo-Inositol Alone vs Myo-Inositol Plus Metformin on Conception, Adherence, and Tolerability in PCOS

Phase 3 Completed

120 enrolled

Polycystic Ovary Syndrome

NCT05023967 2026-01-05

Metformin and Nightly Fasting in Women With Early Breast Cancer

Phase 2 Active not recruiting

120 enrolled

Breast

Carcinoma, Intraductal, Noninfiltrating

NCT04414540 2025-12-19

Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients

Phase 2 Active not recruiting

20 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT04691960 2025-12-19

A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging

Phase 2 Active not recruiting

18 enrolled

CNS

Glioblastoma

Clinical Trials

Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion

METCAP

Morpheus-panBC

PNOC041

A Study to Investigate the Effects of Multiple Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation.

To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer

Metformin Versus Myo-inositol in the Management of Polycystic Ovarian Disease: A Comparative Study

Effect of Liraglutide in Obese Women With Polycystic Ovary Syndrome

Study of Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients Receiving Androgen Deprivation Therapy

Metformin Hydrochloride in Combination With Standard of Care Systemic Therapy in Previously Untreated Advanced Unresectable or Metastatic Soft Tissue Sarcoma

Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saruparib

SHK002

PCOS

Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma

PCOS

Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia

Gemcitabine Hydrochloride, Paclitaxel Albumin-Stabilized Nanoparticle Formulation, Metformin Hydrochloride, and a Standardized Dietary Supplement in Treating Patients With Pancreatic Cancer That Cannot be Removed by Surgery

Myo-inositol Versus Metformin in Patients With Polycystic Ovarian Syndrome to Treat Obesity

PCOS-COMBO (9)

An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer

Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy

A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy

Impact of Myo-Inositol Alone vs Myo-Inositol Plus Metformin on Conception, Adherence, and Tolerability in PCOS

Metformin and Nightly Fasting in Women With Early Breast Cancer

Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients

A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging