Clinical Trials Browser

OTHER × Has results × Metformin × Clear all

NCT02946996 2026-03-05

Study of Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients Receiving Androgen Deprivation Therapy

Phase 2 Terminated

41 enrolled 8 charts

Prostatic Neoplasms

NCT04850846 2026-02-09

Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma

Phase 2 Active not recruiting

60 enrolled 10 charts

Smoldering Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance

NCT03109847 2025-12-11

Metformin to Mitigate Sequelae of Radioactive Iodine Treatment for Thyroid Cancers

Phase 2 Terminated

13 enrolled 8 charts

Thyroid Diseases

NCT02186847 2025-10-09

Chemotherapy and Radiation Therapy With or Without Metformin Hydrochloride in Treating Patients With Stage III Non-small Cell Lung Cancer

Phase 2 Completed

170 enrolled 19 charts

Adenocarcinoma of Lung, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung

NCT02500147 2025-07-02

Metformin for Ectopic Fat Deposition and Metabolic Markers in Polycystic Ovary Syndrome (PCOS)

Phase 4 Terminated

3 enrolled 5 charts

Acne Vulgaris, Amenorrhea, Hirsutism, Polycystic Ovary Syndrome, Metabolic Syndrome, Dyslipidemias, Non-alcoholic Fatty Liver Disease

NCT03109873 2025-04-30

Metformin Hydrochloride in Affecting Cytokines and Exosomes in Patients With Head and Neck Cancer

Phase EARLY_PHASE1 Completed

9 enrolled 6 charts

Lymphoid Interstitial Pneumonia, Laryngeal Diseases

NCT01905046 2025-04-13

Metformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia or In Situ Breast Cancer

Phase 3 Active not recruiting

86 enrolled 10 charts

Breast Carcinoma In Situ, Carcinoma, Intraductal, Noninfiltrating

NCT02035787 2024-12-18

Metformin With the Levonorgestrel-Releasing Intrauterine Device for the Treatment of Complex Atypical Hyperplasia (CAH) and Endometrial Cancer (EC) in Non-surgical Patients

Phase 2 Completed

20 enrolled 12 charts

Endometrial Neoplasms

NCT03800602 2024-09-05

Nivolumab and Metformin in Patients With Treatment Refractory MSS Colorectal Cancer

Phase 2 Completed

29 enrolled 7 charts

Gastrointestinal

Colorectal Neoplasms

NCT02431676 2024-08-28

SPIRIT

Phase 2 Completed

121 enrolled 12 charts

BreastDermatologicGastrointestinalGenitourinaryGynecologicThoracic

Breast Neoplasms, Colonic Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Endometrial Neoplasms

NCT00984490 2024-02-01

Metformin Hydrochloride in Treating Women With Stage I or Stage II Breast Cancer That Can Be Removed By Surgery

Phase NA Terminated

5 enrolled 4 charts

Breast Neoplasms

NCT02949700 2023-06-29

Phase I/II Study OF Metformin in Combination With Cisplatin and Radiation in Head and Neck Squamous Cell Carcinoma

Phase 1/2 Completed

26 enrolled 14 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02028221 2023-06-27

Phase II Study of Metformin for Reduction of Obesity-Associated Breast Cancer Risk

Phase 2 Completed

151 enrolled 15 charts

Breast Cancer Prevention

NCT00930579 2022-10-20

Pre-Surgical Study: Effect of Metformin on Breast Cancer Proliferation

Phase 2 Completed

35 enrolled 5 charts

Breast Neoplasms

NCT02176161 2022-10-18

Metformin Prostate Cancer Adjuvant Trial

Phase 2 Completed

59 enrolled 8 charts

Prostatic Neoplasms

NCT02531308 2022-09-28

DLBCL

Phase 2 Terminated

5 enrolled 5 charts

LymphoidSarcoma

Lymphoma, Lymphoma, Large B-Cell, Diffuse, Dendritic Cell Sarcoma, Interdigitating

NCT02614859 2022-03-29

BIMET-1

Phase 2 Completed

29 enrolled 10 charts

Prostatic Neoplasms

NCT01482286 2022-03-15

PULSE

Phase 3 Terminated

32 enrolled 10 charts

Body Weight, Insulin Resistance, Motor Activity, Polycystic Ovary Syndrome

NCT01666730 2021-08-10

Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer

Phase 2 Completed

50 enrolled 13 charts

Gastrointestinal

Pancreatic Neoplasms

NCT02635386 2021-01-29

EQW, DAPA, EQW/DAPA, DAPA/MET ER and PHEN/TPM ER in Obese Women With PolycysticOvary Syndrome (PCOS)

Phase 3 Completed

119 enrolled 34 charts

Obesity, Polycystic Ovary Syndrome

NCT03048500 2020-10-14

Nivolumab and Metformin Hydrochloride in Treating Patients With Stage III-IV Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

Phase 2 Unknown

17 enrolled 10 charts

Carcinoma, Non-Small-Cell Lung

NCT01627067 2020-06-19

Exemestane-RAD001-Metformin

Phase 2 Terminated

23 enrolled 7 charts

Breast Neoplasms

NCT02325401 2020-06-11

Dose-finding Study of Metformin With Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase 1 Completed

20 enrolled 11 charts

Head and Neck Neoplasms

NCT01302379 2020-06-05

Reach for Health Study: Obesity-related Mechanisms and Mortality in Breast Cancer Survivors

Phase NA Completed

333 enrolled 17 charts

Breast Neoplasms, Obesity, Weight Loss

NCT01717482 2020-03-10

Metformin as a Chemoprevention Agent in Non-small Cell Lung Cancer

Phase 2 Terminated

6 enrolled 5 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT03117517 2020-03-02

Treatment With Metformin and Combination of Metformin and Pioglitazone in Polycystic Ovarian Syndrome

Phase EARLY_PHASE1 Completed

106 enrolled 7 charts

Polycystic Ovary Syndrome

NCT02285855 2020-01-06

Metformin in Non Small Cell Lung Cancer (NSCLC)

Phase 2 Terminated

27 enrolled 11 charts

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT01849276 2019-01-31

Metformin+Cytarabine for the Treatment of Relapsed/Refractory AML

Phase 1 Terminated

2 enrolled 9 charts

Other hematologic neoplasm

Congenital Abnormalities, Blast Crisis, Leukemia, Erythroblastic, Acute, Leukemia, Megakaryoblastic, Acute, Leukemia, Monocytic, Acute, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Acute

NCT01578551 2018-12-19

Study of Metformin Plus Paclitaxel/Carboplatin/Bevacizumab in Patients With Adenocarcinoma.

Phase 2 Terminated

25 enrolled 9 charts

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung

NCT01579812 2018-05-25

Evaluation of Metformin, Targeting Cancer Stem Cells for Prevention of Relapse in Gynecologic Patients

Phase 2 Completed

90 enrolled 9 charts

Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

NCT01620593 2018-05-23

Castration Compared to Castration Plus Metformin as First Line Treatment for Patients With Advanced Prostate Cancer

Phase 2 Completed

41 enrolled 7 charts

Prostatic Neoplasms

NCT02019979 2018-05-04

METRO

Phase 2 Terminated

14 enrolled 7 charts

Lung Neoplasms

NCT00151411 2018-03-21

Lifestyle Intervention and Metformin for Women With Polycystic Ovary Syndrome (PCOS)

Phase 2 Completed

114 enrolled 10 charts

Anovulation, Polycystic Ovary Syndrome

NCT02376166 2017-12-22

M-RePoRT

Phase NA Completed

15 enrolled 26 charts

Prostatic Neoplasms

NCT02815397 2017-11-17

DLBCL

Phase 2 Terminated

2 enrolled 3 charts

Lymphoma, Large B-Cell, Diffuse

NCT02360059 2017-08-17

Metformin for Reduction of Paclitaxel-Related Neuropathy in Patients With Breast Cancer

Phase 2 Terminated

1 enrolled 3 charts

Breast Neoplasms

NCT00703508 2017-06-14

Pharmacogenetics of Metformin Action in PCOS

Phase NA Completed

55 enrolled 7 charts

Polycystic Ovary Syndrome

NCT01215032 2017-05-15

Metformin in Castration-Resistant Prostate Cancer

Phase 2 Terminated

21 enrolled 8 charts

Prostatic Neoplasms

NCT01632020 2016-07-11

Effect of Metformin on Biomarkers of Colorectal Tumor Cell Growth

Phase 2 Terminated

7 enrolled 6 charts

Gastrointestinal

Colorectal Neoplasms

NCT02498522 2016-05-19

MIP

Phase EARLY_PHASE1 Completed

166 enrolled 6 charts

Polycystic Ovary Syndrome

NCT00283816 2015-05-15

Impact of Metformin in Teens With Polycystic Ovary Syndrome (PCOS) on Oral Contraceptive Therapy

Phase 3 Completed

36 enrolled 9 charts

Menstruation Disturbances, Polycystic Ovary Syndrome

NCT00714233 2015-05-15

Treatment of Adolescent Polycystic Ovary Syndrome (PCOS)

Phase 3 Completed

43 enrolled 13 charts

Menstruation Disturbances, Polycystic Ovary Syndrome

NCT01486043 2015-01-30

Metformin and Transient Hyperglycemia

Phase NA Terminated

4 enrolled 9 charts

LymphoidOther hematologic neoplasm

Diabetes Mellitus, Hyperglycemia, Insulin Resistance, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00682890 2014-08-20

Combination Metformin and Oral Contraception for Polycystic Ovary Syndrome (PCOS)

Phase 4 Terminated

28 enrolled 7 charts

Insulin Resistance, Polycystic Ovary Syndrome

NCT00670800 2014-05-21

Study of Brain Function in Women With Insulin Resistant Polycystic Ovary Syndrome

Phase NA Completed

14 enrolled 9 charts

Insulin Resistance, Polycystic Ovary Syndrome

NCT01410604 2012-04-27

Adipokines in Obese Adolescents With Insulin Resistance

Phase 4 Completed

31 enrolled 15 charts

Insulin Resistance, Obesity