Clinical Trials

Phase 2 Active not recruiting

Small Cell Lung Carcinoma

NCT01857934 2025-11-17

Therapy for Children With Advanced Stage Neuroblastoma

153 enrolled 12 charts

Phase 2 Active not recruiting

Neuroblastoma

NCT03786783 2025-10-09

Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma

42 enrolled 12 charts

Ganglioneuroblastoma

NCT01931098 2025-08-11

Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab

35 enrolled 13 charts

CNSSarcoma

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT02569957 2025-05-04

Effect of Acetylcysteine With Topotecan Hydrochloride on the Tumor Microenvironment in Patients With Persistent or Recurrent High Grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

1 enrolled 5 charts

Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT02312245 2024-12-05

Avatar-Directed Chemotherapy in Treating Patients With Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

13 enrolled 14 charts

Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT04768296 2024-09-26

Berzosertib + Topotecan in Relapsed Platinum-Resistant Small-Cell Lung Cancer (DDRiver SCLC 250)

76 enrolled 42 charts

Hereditary Sensory and Autonomic Neuropathies, Small Cell Lung Carcinoma

NCT01696032 2024-08-27

SGI-110

120 enrolled 22 charts

Ovarian Neoplasms

NCT00601003 2024-08-06

Study of Nifurtimox to Treat Refractory or Relapsed Neuroblastoma or Medulloblastoma

112 enrolled 10 charts

Medulloblastoma, Neuroblastoma

NCT02200757 2024-06-25

Efficacy and Safety of Aldoxorubicin Compared to Topotecan in Subjects With Metastatic Small Cell Lung Cancer

135 enrolled 11 charts

Small Cell Lung Carcinoma

NCT00057837 2023-07-05

Comparison of Two Combination Chemotherapy Regimens in Treating Patients With Extensive-Stage Small Cell Lung Cancer

140 enrolled 8 charts

Extensive Stage Small Cell Lung Cancer

NCT02963090 2023-02-15

Pembrolizumab vs Topotecan in Patients With Small Cell Lung Cancer

9 enrolled 11 charts

Lung Neoplasms, Small Cell Lung Carcinoma

NCT02357810 2022-06-07

Pazopanib Hydrochloride and Topotecan Hydrochloride in Treating Patients With Metastatic Soft Tissue and Bone Sarcomas

178 enrolled 16 charts

Sarcoma

Liposarcoma, Sarcoma, Osteosarcoma

NCT01004874 2022-04-13

Avastin/Radiation (XRT)/Temozolomide (Temodar) Followed by Avastin/Temodar/Topotecan for Glioblastoma

80 enrolled 11 charts

CNSSarcoma

Glioblastoma, Glioma, Gliosarcoma

NCT01803269 2020-06-26

Topotecan Hydrochloride or Cyclodextrin-Based Polymer-Camptothecin CRLX101 in Treating Patients With Recurrent Small Cell Lung Cancer

29 enrolled 14 charts

Small Cell Lung Carcinoma

NCT01492673 2019-10-29

Cyclophosphamide, Topotecan, and Bevacizumab (CTB) in Patients With Relapsed/Refractory Ewing's Sarcoma and Neuroblastoma

9 enrolled 9 charts

CNSSarcoma

Neuroblastoma, Sarcoma, Sarcoma, Ewing

NCT01266447 2019-08-08

Veliparib, Topotecan Hydrochloride, and Filgrastim or Pegfilgrastim in Treating Patients With Persistent or Recurrent Cervical Cancer

27 enrolled 11 charts

Uterine Cervical Neoplasms

NCT00065182 2019-06-24

Comparison of IV Topotecan/Docetaxel to Docetaxel Alone in Second-Line Stage IIIB/IV Non-Small Cell Lung Cancer

399 enrolled 12 charts

Carcinoma, Non-Small-Cell Lung

NCT00087126 2019-01-08

Topotecan in Treating Women With Persistent or Recurrent Cervical Cancer

27 enrolled 6 charts

Uterine Cervical Neoplasms

NCT00114166 2018-07-24

Topotecan in Treating Patients With Recurrent Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer

81 enrolled 10 charts

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT00098956 2018-07-23

7-hydroxystaurosporine and Topotecan Hydrochloride in Treating Patients With Relapsed or Progressed Small Cell Lung Cancer

19 enrolled 9 charts

Small Cell Lung Carcinoma

NCT00365547 2017-12-28

Topotecan and Bevacizumab in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer That Did Not Respond to Previous Systemic Chemotherapy

46 enrolled 11 charts

Adenocarcinoma of Lung, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00828139 2017-08-21

S0802 - Topotecan With or Without Aflibercept in Treating Patients With Extensive-Stage Small Cell Lung Cancer

189 enrolled 15 charts

Small Cell Lung Carcinoma

NCT00808899 2017-05-30

Neuroblastoma Protocol 2008: Therapy for Children With Advanced Stage High Risk Neuroblastoma

4 enrolled 5 charts

Neuroblastoma

NCT01003938 2016-06-30

Topotecan With Erlotinib for Topotecan Pretreated Ovarian Cancer

6 enrolled 7 charts

Ovarian Neoplasms

NCT01533181 2016-01-14

Linsitinib or Topotecan Hydrochloride in Treating Patients With Relapsed Small Cell Lung Cancer

44 enrolled 10 charts

Small Cell Lung Carcinoma

NCT00313612 2015-11-27

Oxaliplatin and Topotecan in Advance Ovarian Cancer

39 enrolled 7 charts

Carcinoma, Ovarian Epithelial

NCT00437073 2015-10-15

Brain Metastases In ErbB2-Positive Breast Cancer

22 enrolled 8 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT00634244 2015-07-07

Comparing Three Different Combination Chemotherapy Regimens in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia