Clinical Trials

Urothelial Cancer

NCT04887831 2025-09-08

PRESERVE3

92 enrolled 24 charts

Urinary Bladder Neoplasms, Carcinoma, Transitional Cell

NCT02684006 2025-07-30

JAVELIN Renal 101

886 enrolled 37 charts 1 FDA

Carcinoma, Renal Cell, Kidney Diseases, Kidney Neoplasms, Neoplasms

NCT03724890 2025-04-10

Study of Avelumab-M3814 Combinations

57 enrolled 56 charts

Tumor-Agnostic

Neoplasms

NCT05431777 2025-04-01

A Study to Learn About the Study Medicine (Avelumab) in Japanese Patients With Urothelial Carcinoma That Has Spread

Completed

79 enrolled 20 charts

Carcinoma, Transitional Cell

NCT02576574 2025-01-31

Avelumab in First-line NSCLC (JAVELIN Lung 100)

1,214 enrolled 40 charts

Phase 2 Active not recruiting

Carcinoma, Non-Small-Cell Lung

NCT04215146 2025-01-16

A Study to Assess Overall Response Rate by Inducing an Inflammatory Phenotype in Metastatic BReast cAnCEr With the Oncolytic Reovirus PeLareorEp in CombinaTion With Anti-PD-L1 Avelumab and Paclitaxel - BRACELET-1 Study

48 enrolled 13 charts

Breast

Breast Neoplasms

NCT03329248 2024-12-12

QUILT-3.060: NANT Pancreatic Cancer Vaccine: Molecularly Informed Integrated Immunotherapy in Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy

6 enrolled 15 charts

Pancreatic Neoplasms

NCT03563157 2024-12-11

QUILT 3.071: NANT Colorectal Cancer (CRC) Vaccine

2 enrolled 13 charts

Colorectal Neoplasms

NCT02994953 2024-09-20

COMBO

Phase 1 Terminated

52 enrolled 34 charts

Other solid neoplasm

Advanced Solid Tumors

NCT03586869 2024-08-27

QUILT-3.080: NANT Pancreatic Cancer Vaccine

3 enrolled 13 charts

Pancreatic Neoplasms

NCT03387085 2024-08-09

QUILT-3.067: NANT Triple Negative Breast Cancer (TNBC) Vaccine: Molecularly Informed Integrated Immunotherapy in Subjects With TNBC Who Have Progressed on or After Standard-of-care Therapy.

9 enrolled 18 charts

Breast

Triple Negative Breast Neoplasms

NCT03853317 2024-08-09

QUILT-3.063: A Study of N-803, haNK and Avelumab in Patients With Merkel Cell Carcinoma That Has Progressed After Checkpoint Therapy

9 enrolled 13 charts

Dermatologic

Carcinoma, Merkel Cell

NCT03387111 2024-08-05

QUILT-3.090: NANT Squamous Cell Carcinoma (SCC) Vaccine: Subjects With SCC Who Have Progressed

4 enrolled 14 charts

Tumor-Agnostic

Carcinoma, Squamous Cell

NCT03451825 2024-06-24

Phase I/II Study of Avelumab in Pediatric Cancer Participants

Phase 1 Terminated

21 enrolled 21 charts

CNSLymphoid

Lymphoma, Central Nervous System Neoplasms

NCT03136406 2024-06-11

QUILT-3.039: NANT Pancreatic Cancer Vaccine: Combination Immunotherapy in Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy

3 enrolled 9 charts

Pancreatic Neoplasms

NCT03387098 2024-05-22

QUILT-3.070:Pancreatic Cancer Vaccine: Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy

4 enrolled 9 charts

Pancreatic Neoplasms

NCT03472560 2024-04-09

A Study of Avelumab in Combination With Axitinib In Non-Small Cell Lung Cancer (NSCLC) or Urothelial Cancer (Javelin Medley VEGF)

61 enrolled 26 charts

GenitourinaryThoracic

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasms

NCT03558139 2024-04-01

Study of Magrolimab (Hu5F9-G4) in Combination With Avelumab in Solid Tumor Participants and Checkpoint-Inhibitor-Naive Ovarian Cancer Participants Who Progress Within 6 Months of Prior Platinum Chemotherapy

34 enrolled 17 charts

Ovarian Neoplasms

NCT02603432 2024-03-27

JAVELIN Bladder 100

700 enrolled 35 charts 2 FDA

Urinary Bladder Neoplasms, Carcinoma, Transitional Cell, Urologic Neoplasms

NCT02155647 2024-03-13

Avelumab in Participants With Merkel Cell Carcinoma (JAVELIN Merkel 200)

Phase 2 Completed

204 enrolled 32 charts

Dermatologic

Carcinoma, Merkel Cell

NCT03523390 2024-02-23

Phase I/Ib Multiple Ascending Dose Study in China

24 enrolled 24 charts

Other solid neoplasm

Metastatic Solid Tumors

NCT02915523 2024-01-10

Study of Avelumab With or Without Entinostat in Participants With Advanced Epithelial Ovarian Cancer

Phase 1/2 Completed

140 enrolled 25 charts

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Ovarian Diseases, Ovarian Neoplasms

NCT05012865 2023-12-06

Current Treatment Outcomes in Japanese RCC Patients Treated With Avelumab Plus Axitinib as First-line Therapy: Retrospective Study (J-DART)

Completed

48 enrolled 36 charts

Carcinoma, Renal Cell

NCT03330405 2023-10-13

Javelin Parp Medley: Avelumab Plus Talazoparib In Locally Advanced Or Metastatic Solid Tumors

BreastGynecologicThoracic

223 enrolled 50 charts

Carcinoma, Ovarian Epithelial, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Recurrence

NCT03565991 2023-09-25

Javelin BRCA/ATM: Avelumab Plus Talazoparib in Patients With BRCA or ATM Mutant Solid Tumors

202 enrolled 31 charts

Hereditary Sensory and Autonomic Neuropathies

NCT03317496 2023-08-29

Safety And Efficacy Study Of Avelumab Plus Chemotherapy With Or Without Other Anti-Cancer Immunotherapy Agents In Patients With Advanced Malignancies

67 enrolled 24 charts

Carcinoma, Non-Small-Cell Lung

NCT02580058 2023-07-10

JAVELIN Ovarian 200

566 enrolled 40 charts

Ovarian Neoplasms

NCT02584634 2023-07-07

Javelin Lung 101

43 enrolled 40 charts

Carcinoma, Non-Small-Cell Lung

NCT02625610 2022-06-09

Avelumab in First-Line Maintenance Gastric Cancer (JAVELIN Gastric 100)

499 enrolled 22 charts

Tumor-Agnostic

Neoplasm Metastasis, Neoplasms

NCT03717155 2022-06-06

Study of Avelumab and Cetuximab Plus Gemcitabine and Cisplatin in Participants With NSCLC

Phase 2 Completed

43 enrolled 18 charts

Carcinoma, Non-Small-Cell Lung

NCT02493751 2022-02-18

JAVELIN Renal 100

55 enrolled 27 charts

Carcinoma, Renal Cell, Kidney Diseases, Kidney Neoplasms, Neoplasms

NCT04052204 2021-10-14

Avelumab With Bempegaldesleukin With or Without Talazoparib or Enzalutamide in Advanced or Metastatic Solid Tumors

3 enrolled 12 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT02952586 2021-09-22

Study To Compare Avelumab In Combination With Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment In Patients With Locally Advanced Squamous Cell Carcinoma Of The Head And Neck (JAVELIN HEAD AND NECK 100)

Phase 3 Terminated

697 enrolled 26 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT02349633 2021-06-10

Study For Patients With NSCLC EGFR Mutations (Del 19 or L858R +/- T790M)

65 enrolled 61 charts

Carcinoma, Non-Small-Cell Lung

NCT02222922 2020-12-17

A Study Of PF-06647020 For Adult Patients With Advanced Solid Tumors

BreastGynecologicThoracic

138 enrolled 98 charts

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Triple Negative Breast Neoplasms

NCT02951156 2020-12-17

Javelin DLBCL

Phase 3 Terminated

29 enrolled 24 charts

Lymphoid

Lymphoma, Large B-Cell, Diffuse

NCT02625623 2020-11-24

Avelumab in Third-Line Gastric Cancer (JAVELIN Gastric 300)

371 enrolled 18 charts

Recurrence, Stomach Neoplasms

NCT03704467 2020-11-13

Phase Ib/II Study of Carboplatin + M6620 + Avelumab in PARPi-resistant Ovarian Cancer

3 enrolled 11 charts

Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT02395172 2020-08-03

Avelumab in Non-Small Cell Lung Cancer (JAVELIN Lung 200)

792 enrolled 26 charts

Carcinoma, Non-Small-Cell Lung

NCT02718417 2020-07-14

JAVELIN OVARIAN 100

Phase 3 Terminated

998 enrolled 39 charts