Clinical Trials

164 enrolled 10 charts

Thyroid Neoplasms

NCT03630120 2021-07-14

Adaptive Tyrosine Kinase Inhibitor (TKI) Therapy In Patients With Thyroid Cancer

6 enrolled 9 charts

EndocrineHead & Neck

Thyroid cancer, medullary, Thyroid Cancer, Papillary, Thyroid Diseases, Thyroid Neoplasms, Adenocarcinoma, Follicular, Carcinoma, Medullary

NCT01414426 2021-01-14

Vandetanib in Preventing Head and Neck Cancer in Patients With Precancerous Head and Neck Lesions

Head & NeckOther neoplasm

20 enrolled 7 charts

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Precancerous Conditions

NCT02015065 2020-03-30

Phase II Trial of Vandetanib in Children and Adults With Wild-Type Gastrointestinal Stromal Tumors

9 enrolled 14 charts

Sarcoma

GIST

NCT00613626 2020-02-11

Cisplatin + Etoposide +/- Concurrent ZD6474 in Previously Untreated Extensive Stage Small Cell Lung Cancer

74 enrolled 19 charts

Small Cell Lung Carcinoma

NCT00459121 2019-03-26

Vandetanib, Carboplatin, and Paclitaxel in Treating Patients With Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer That Can Be Removed by Surgery

2 enrolled 4 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00566995 2018-10-30

Phase II Study of Vandetanib in Individuals With Kidney Cancer

37 enrolled 16 charts

Carcinoma, Renal Cell, Kidney Neoplasms

NCT00880334 2018-09-18

Randomized Study of Docetaxel +/- Vandetanib in Metastatic TCC

149 enrolled 12 charts

Urinary Bladder Neoplasms, Carcinoma, Transitional Cell

NCT00687297 2018-05-30

Study of Vandetanib Combined With Chemotherapy to Treat Advanced Non-small Cell Lung Cancer

162 enrolled 9 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00098345 2018-05-07

Efficacy and Tolerability of ZD6474 in Patients With Thyroid Cancer

40 enrolled 12 charts

Thyroid Neoplasms

NCT00500292 2018-01-25

A Phase II Study of 2 Doses of ZD6474 (Vandetanib) in Combination With FOLFOX vs FOLFOX Alone for the Treatment of Colorectal Cancer

109 enrolled 8 charts

Tumor-Agnostic

Neoplasms

NCT00481845 2017-02-07

Phase 2 Anastrozole and Vandetanib (ZD6474) in Neoadjuvant Treatment of Postmenopausal Hormone Receptor-Positive Breast Cancer

1 enrolled 8 charts

Breast

Breast Neoplasms

NCT00358956 2017-01-30

A Study To Assess ZD6474 (ZACTIMA™) Monotherapy In Locally Advanced or Metastatic Hereditary Medullary Thyroid Cancer

19 enrolled 10 charts

EndocrineHead & Neck

Familial medullary thyroid carcinoma, Thyroid Neoplasms, Carcinoma, Medullary

NCT00686036 2016-12-21

ZENITH

17 enrolled 4 charts

Prostatic Neoplasms

NCT00872989 2016-12-19

S0904: Docetaxel With or Without Vandetanib in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer

129 enrolled 17 charts

Gynecologic

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT00752986 2016-12-05

ZACFAST

39 enrolled 7 charts

Breast

Breast Neoplasms, Neoplasm Metastasis

NCT00753714 2016-10-17

ZELIG

124 enrolled 11 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Pleural Effusion

NCT00597116 2016-10-10

An Efficacy and Safety Study With Vandetanib to Treat Inoperable or Relapsed Malignant Mesothelioma

Other solid neoplasmThoracic

25 enrolled 8 charts

Mesothelioma, Recurrence

NCT00753675 2016-10-10

VANGOGH

174 enrolled 12 charts

Gastrointestinal

Biliary Tract Neoplasms, Gallbladder Neoplasms, Cholangiocarcinoma

NCT00777179 2016-10-10

Phase II of Zactima Maintenance for Locally Advanced or Metastatic Non-small-cell Lung Carcinoma (NSCLC) Following Platinum-doublet Chemotherapy

117 enrolled 15 charts

Carcinoma, Non-Small-Cell Lung

NCT00454116 2016-10-07

A Phase II, Double Blind Study of 2 Doses of ZACTIMA™(ZD6474) in Combination With FOLFIRI vs FOLFIRI Alone for the Treatment of Colorectal Cancer in Patients

106 enrolled 8 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00498797 2016-10-07

E3-Hormone Refractory Prostrate Cancer Taxotere Combination

86 enrolled 8 charts

Neoplasm Metastasis, Prostatic Neoplasms

NCT00494481 2016-09-30

E3 Breast Cancer Taxotere Combination

64 enrolled 7 charts

Breast

Advanced Breast Cancer

NCT00290537 2016-05-19

Phase II Study of ZD6474 in Advanced NSCLC

4 enrolled 3 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00995007 2016-03-29

A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas

112 enrolled 12 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma, Disease Progression

NCT00720083 2015-11-17

Chemotherapy and Radiation Therapy (RT) With or Without Vandetanib in Treating Patients With High-Risk Stage III or Stage IV Head and Neck Cancer

34 enrolled 5 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT01372813 2015-10-23

Vandetanib to Treat Advanced Kidney Cancer

3 enrolled 10 charts

Carcinoma, Renal Cell, Kidney Neoplasms, Neoplasms

NCT00410189 2015-03-23

BATTLE Program: ZD6474 in Previously Treated Subjects With NSCLC

54 enrolled 8 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00459043 2013-07-03

Docetaxel in Combination With Zactima (ZD6474) in Patients With Locally Advanced Squamous Cell Carcinoma of the the Head and Neck

30 enrolled 10 charts

Squamous Cell Carcinoma of Head and Neck

NCT00445549 2012-06-26

Vandetanib to Treat Women With Ovarian, Fallopian Tube, or Primary Peritoneal Cancer