Clinical Trials Browser

Completed × OTHER × AZD 6244 × Clear all

NCT03581487 2025-11-05

Durvalumab, Tremelimumab, and Selumetinib in Treating Participants With Recurrent or Stage IV Non-small Cell Lung Cancer

Phase 1/2 Completed

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT01256359 2024-08-15

DOC-MEK

Phase 2 Completed

83 enrolled 60 charts

Melanoma

NCT02393690 2024-07-26

Iodine I-131 With or Without Selumetinib in Treating Patients With Recurrent or Metastatic Thyroid Cancer

Phase 2 Completed

60 enrolled 12 charts

EndocrineHead & Neck

Thyroid Cancer, Papillary, Thyroid Neoplasms, Adenocarcinoma, Follicular

NCT02117167 2024-01-10

SAFIR02_Lung

Phase 2 Completed

Non-small Cell Lung Cancer Metastatic

NCT03433183 2023-12-26

SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors

Phase 2 Completed

Neurofibromatosis 1, Neurofibrosarcoma

NCT02768766 2023-08-31

Intermittent Selumetinib for Uveal Melanoma

Phase 1 Completed

Uveal Melanoma, Melanoma

NCT02503358 2023-03-21

Selumetinib and Paclitaxel as Second-Line Treatment in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer

Phase 1 Completed

Carcinoma, Non-Small-Cell Lung

NCT01146756 2023-02-15

MEKRT

Phase 1 Completed

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT01248247 2022-01-12

BATTLE-2 Program: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small Cell Lung Cancer

Phase 2 Completed

334 enrolled 14 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT01586624 2021-10-07

A Phase I Trial of Vandetanib (AZD6474) and Selumetinib (AZD6244) for Solid Tumours Including Non Small Cell Lung Cancer (VanSel-1)

Phase 1 Completed

61 enrolled 23 charts

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT01160718 2019-05-15

Fulvestrant With or Without AZD6244 in Treating Patients With Advanced Breast Cancer That Progressed After Aromatase Inhibitor Therapy

Phase 2 Completed

Breast Neoplasms

NCT02025114 2018-07-10

Selumetinib in Combination With Gefitinib in NSCLC Patients

Phase 1/2 Completed

Carcinoma, Non-Small-Cell Lung

NCT00970359 2017-04-12

Reacquisition of Radioactive Iodine (RAI) Uptake of RAI-Refractory Metastatic Thyroid Cancers by Pretreatment With the Selective MEK Inhibitor AZD6244

Phase NA Completed

24 enrolled 8 charts

Neoplasm Metastasis, Thyroid Diseases, Thyroid Neoplasms

NCT01313039 2017-02-07

Evaluation of the Use of AZD6244 to Induce Increased ER Expression and Anti-Estrogen Response in ER-Negative/Low Breast Cancer

Phase EARLY_PHASE1 Completed

4 enrolled 5 charts

Breast Neoplasms

NCT01242605 2016-05-13

ABC-04

Phase 1 Completed

Gastrointestinal

Biliary Tract Neoplasms, Gallbladder Neoplasms, Cholangiocarcinoma