NCT05593094 2026-02-25A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Solid TumorsHoffmann-La RochePhase 1/2 Active not recruiting210 enrolled
NCT04158258 2026-02-12A Study to Describe the Diagnosis, Anti-Cancer Treatment and Clinical Outcome in Patients With Newly Diagnosed Breast Cancer in Latin AmericaHoffmann-La RocheActive not recruiting2,907 enrolled
NCT00781612 2025-12-24A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent StudiesGenentech, Inc.Phase 2 Active not recruiting720 enrolled
NCT03975647 2025-12-10A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast CancerSeagen Inc.Phase 3 Active not recruiting466 enrolled 17 charts
NCT03529110 2025-10-21DS-8201a Versus T-DM1 for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive, Unresectable and/or Metastatic Breast Cancer Previously Treated With Trastuzumab and Taxane [DESTINY-Breast03]Daiichi SankyoPhase 3 Active not recruiting524 enrolled 11 charts 1 FDA