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NCT06665724 2026-02-27

Clinical Trial Evaluating Safety of 5-Aminolevulinic Acid (5-ALA) Combined With CV01 Delivery of Ultrasound for Sonodynamic Therapy (SDT) in Patients With Newly Diagnosed High-Grade Glioma (HGG) Prior to Resection and Standard Adjuvant Therapy (ALA SDT GLIOMA 401)

Phase 1 Completed

Astrocytoma, Glioblastoma, Oligodendroglioma

NCT07038278 2026-02-27

5-ALARMS

Phase EARLY_PHASE1 Not yet recruiting

Sarcoma

NCT07076472 2026-02-23

Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma

Phase EARLY_PHASE1 Recruiting

Glioblastoma

NCT05923060 2026-02-20

Imaging Techniques to Monitor Photosensitizer and sO2 Levels During Photodynamic Therapy of Actinic Keratoses

Phase 2 Completed

Keratosis, Actinic

NCT06623201 2026-01-29

Blue-Light Photodynamic Therapy and Sonidegib for Multiple Basal Cell Carcinomas

Phase 1 Recruiting

Carcinoma, Basal Cell

NCT06907485 2026-01-21

A Multicenter Study to Assess the Feasibility of 5-Aminolevulinic Acid (5-ALA) in Pediatric Brain Tumor Patients

Phase 2 Not yet recruiting

Brain Neoplasms

NCT07053852 2026-01-02

Activation of Ameluz With BBL HEROic for the Treatment of Actinic Keratoses and Photodamage

Phase 1 Completed

Keratosis, Actinic

NCT04738162 2025-12-10

Clinical Safety Study on 5-Aminolevulinic Acid (5-ALA) in Children and Adolescents With Brain Tumors

Phase 2 Completed

Brain Neoplasms

NCT05020912 2025-11-26

Alteration of the Immune Microenvironment in Basal Cell Carcinoma Following Photodynamic Therapy

Phase 2 Recruiting

Carcinoma, Basal Cell

NCT06027619 2025-10-23

Short Contact Protocols to Reduce Pain During 10% ALA Gel Red-light Photodynamic Therapy of Actinic Keratoses

Phase 2 Completed

30 enrolled 13 charts

Keratosis, Actinic

NCT02191488 2025-09-15

ALA-induced PpIX Fluorescence During Brain Tumor Resection

Phase 1 Active not recruiting

Brain Neoplasms, Glioma

NCT02691923 2025-08-03

Diagnostic Performance of Fluorescein as an Intraoperative Brain Tumor Biomarker

Phase 2 Recruiting

Brain Neoplasms, Glioma

NCT05101798 2025-07-28

The Role of 5-Aminolevulinic Acid Fluorescence-Guided Surgery in Head and Neck Cancers: a Pilot Trial

Phase 2 Terminated

7 enrolled 5 charts

Head and Neck Neoplasms, Neoplasms, Skull Base Neoplasms

NCT02728388 2025-05-08

Photodynamic Therapy for Benign Dermal Neurofibromas- Phase II

Phase 2 Recruiting

Neurofibroma, Neurofibromatosis 1

NCT06948552 2025-04-29

Photodynamic Diagnosis of Upper Tract Urothelial Carcinoma Using Fluorescence Endoscopy and Oral 5-ALA

Phase 2 Not yet recruiting

Kidney Neoplasms

NCT04469699 2025-03-11

NOA11

Phase 2 Terminated

Glioblastoma

NCT06159842 2025-02-12

Evaluating the Use of Photodynamic Therapy to Treat Facial Cutaneous Squamous Cell Carcinoma in Situ (isSCC)

Phase 2 Completed

DermatologicGynecologic

Squamous Intraepithelial Lesions, Carcinoma, Squamous Cell, Skin Neoplasms

NCT03066843 2025-01-31

Photodynamic Therapy Incubation Times for Actinic Keratosis

Phase NA Active not recruiting

Keratosis, Actinic

NCT06745999 2024-12-24

Cryotherapy in Combination with Red Light PDT for Actinic Keratosis of Full Face

Phase 4 Recruiting

Keratosis, Actinic

NCT05590689 2024-12-16

ALA-RDTinGBM

Phase 1/2 Recruiting

Glioblastoma

NCT06577311 2024-08-29

Evaluating the Use of Photodynamic Therapy to Treat Facial Cutaneous Squamous Cell Carcinoma in Situ (SCCis)

Phase 2 Recruiting

DermatologicGynecologic

Squamous Intraepithelial Lesions, Carcinoma, Squamous Cell, Skin Neoplasms

NCT06252727 2024-08-15

Fluorescent Aided Resection and Evaluation of Soft Tissue Sarcomas (FLARES)

Phase 1 Withdrawn

Sarcoma

NCT03963102 2024-07-26

Duration of Ameluz Application in Acral Actinic Keratoses Response

Phase 4 Terminated

Keratosis, Actinic

NCT03327831 2024-06-27

Study of Daylight Photodynamic Therapy With Aminolevulinic Acid for Actinic Keratoses

Phase 4 Completed

30 enrolled 7 charts

Keratosis, Actinic

NCT01128218 2023-11-30

A Study of the Specificity and Sensitivity of 5- Aminolevulinic Acid (ALA) Fluorescence in Malignant Brain Tumors

Phase 1/2 Completed

33 enrolled 15 charts

Brain Neoplasms, Glioblastoma, Glioma

NCT01502280 2023-11-24

BALANCE

Phase 3 Completed

Glioma

NCT05850377 2023-05-09

5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gliomas

Not yet recruiting

Brain Neoplasms, Glioma, Neoplasms, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neoplasms, Neuroepithelial, Neoplasm, Residual

NCT03109353 2023-01-13

Modification of Extracorporeal Photopheresis in Cutaneous T-cell Lymphoma or Chronic Graft-versus-host Disease

Phase 1/2 Completed

DermatologicLymphoid

Lymphoma, T-Cell, Cutaneous

NCT03281811 2023-01-05

Photodynamic Therapy in Treating Patients With Refractory Mycosis Fungoides

Phase EARLY_PHASE1 Completed

Mycosis Fungoides

NCT04055688 2022-05-31

Novel Exoscope System for 5-ALA Fluorescence-Guided Surgery for Gliomas

Brain Neoplasms, Glioma

NCT03322293 2022-03-09

Daylight Photodynamic Therapy for Actinic Keratosis

Phase 1 Completed

24 enrolled 15 charts

Keratosis, Actinic

NCT02751151 2021-10-06

PDT

Phase NA Completed

Nonmelanoma Skin Cancers

NCT00752323 2021-09-17

Imaging Procedure Using ALA in Finding Residual Tumor in Grade IV Malignant Astrocytoma

Phase 2 Completed

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT01682811 2021-06-18

Phase I Photodynamic Therapy (PDT) for Benign Dermal Neurofibromas (NF1)

Phase 1 Completed

20 enrolled 11 charts

Neurofibromatoses

NCT04390802 2021-02-24

A Pilot Study of 5-Aminolevulinic Acid (5-ALA) to Enhance Visualization of Pituitary Adenomas

Pituitary Neoplasms

NCT02867722 2021-02-01

DaylightPDT

Phase NA Withdrawn

Keratosis, Actinic

NCT01556009 2020-11-02

Vismodegib

Phase 2 Completed

Basal Cell Nevus Syndrome, Carcinoma, Basal Cell

NCT02157623 2020-07-30

Blue vs Red Light During Levulan Based Photodynamic Therapy in Patients With Basal Cell Nevus Syndrome

Phase NA Completed

3 enrolled 7 charts

Basal Cell Nevus Syndrome

NCT00977795 2019-09-10

A Study of the Specificity and Sensitivity of 5-ALA Fluorescence in Malignant Brain Tumors

Phase 1/2 Withdrawn

Brain Neoplasms, Glioblastoma, Glioma

NCT00870779 2019-06-14

FGR

Phase 1 Completed

Brain Neoplasms, Glioma, Meningioma, Pituitary Neoplasms, Skull Base Neoplasms

NCT00978081 2019-04-23

Photodynamic Therapy in Treating Patients With Premalignant or Early Stage Head and Neck Tumors

Phase 1 Completed

Head & NeckOther neoplasm

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Precancerous Conditions

NCT00961090 2019-04-12

Safety Study of Aminolevulinic Acid (ALA) to Improve Visibility of Brain Tumors During Surgery

Phase 2 Completed

Brain Neoplasms, Glioblastoma, Glioma

NCT02367547 2019-03-28

Superficial Basal Cell Cancer's Photodynamic Therapy: Comparing Three Photosensitizers: HAL and BF-200 ALA Versus MAL

Phase 1/2 Unknown

Carcinoma, Basal Cell, Neoplasms, Basal Cell

NCT03642535 2019-03-19

Aminolevulinic Acid-photodynamic Therapy for Facial Actinic Keratosis Treatment and Prevention

Phase 4 Unknown

Keratosis, Actinic

NCT01575275 2018-07-31

Aminolevulinic Acid in Visualizing a Tumor During Surgery in Patients With Glioblastoma Multiforme

Phase 2 Terminated

8 enrolled 7 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT02685592 2018-05-30

LM PDT

Phase 4 Completed

Hutchinson's Melanotic Freckle

NCT01310868 2017-10-05

Gliadel Wafer and Fluorescence-Guided Surgery With 5-ALA Followed by Radiation Therapy And Temozolomide in Treating Patients With Primary Glioblastoma

Phase 2 Completed

59 enrolled 8 charts

Glioblastoma, Gliosarcoma

NCT02622594 2017-07-19

Bilateral Comparison of Treatment of Facial Actinic Keratoses Using Microneedling and Photodynamic Therapy With Aminolevulinic Acid and Blue Light Versus Photodynamic Therapy With Aminolevulinic Acid and Blue Light Using Two Incubation Times

Phase 4 Completed

Keratosis, Actinic

NCT01812837 2017-06-15

The Use of Microneedles in Photodynamic Therapy

Phase NA Completed

51 enrolled 7 charts

Keratosis, Actinic

NCT00524485 2017-06-14

Photodynamic Therapy Using Topical Aminolevulinic Acid in Treating Patients With Actinic Keratosis

Phase NA Terminated

12 enrolled 2 charts

DermatologicOther neoplasm

Precancerous Conditions, Keratosis, Actinic