NCT07450352 2026-03-04
SEED-CRYO: Sequential 125I Seed Implantation Followed by Cryoablation vs Single-Modality Local Therapy in Unresectable Solid Tumors
Jinan Military General Hospital
Phase 2 Not yet recruiting
Clinical Trials
27 trialsNCT07437625 2026-02-27
Lesion-Allocated Therapy for Multiple Metastases and Tumor-Zoned Treatment for Bulky Tumors: A Phase II Study of Iodine-125 Seed Implantation Combined With Cryoablation in High-Burden Metastatic Disease
Jinan Military General Hospital
Phase 2 Not yet recruiting
NCT04701918 2026-01-22
Cryoablation With Pembrolizumab Or Avelumab In Urothelial Carcinoma
Massachusetts General Hospital
Phase 2 Completed
NCT05779423 2026-01-06
Cryoablation+Ipilimumab+Nivolumab in Melanoma
Massachusetts General Hospital
Phase 2 Recruiting
NCT07306286 2025-12-29
Cryoablation Combined With the Dual-Function Antibody PD-1/CTLA-4 for the Treatment of LAPC Following Failure of First-Line AG Therapy
Ruijin Hospital
Phase 2 Recruiting
NCT03546686 2025-10-27
Peri-Operative Immune Checkpoint Inhibition and Cryoablation in Women With Triple-negative Breast Cancer
University of Texas Southwestern Medical Center
Phase 2 Recruiting
NCT05949099 2025-09-08
Study of Cryoablation and Nirogacestat for Desmoid Tumor
Stanford University
Phase 2 Recruiting
NCT06127303 2025-09-05
Toripalimab Combined With Cryoablation for First-line Oligo-progression in Driver-negative Advanced NSCLC
Shanghai Chest Hospital
Phase 2 Recruiting
NCT07070700 2025-08-12
CASTLE-ZS-02
Fudan University
Phase 2 Recruiting
NCT02380443 2025-05-16
AlloStim® Immunotherapy Dosing Alone or in Combination With Cryoablation in Metastatic Colorectal Cancer
Mirror Biologics, Inc.
Phase 2 Completed
NCT05098847 2025-02-27
Cryoablation Combined with Sintilimab Plus Lenvatinib in Previously Treated Unresectable Liver Metastasis from Solid Tumors
Fudan University
Phase 2 Recruiting
NCT06032845 2025-02-27
CASTLE-11
Fudan University
Phase 2 Recruiting
NCT05010668 2025-02-21
Cryoablation Combined With Sintilimab Plus Lenvatinib in Patients With Advanced Intrahepatic Cholangiocarcinoma
Fudan University
Phase 2 Completed
NCT05302921 2025-01-01
Neoadjuvant Dual Checkpoint Inhibition and Cryoablation in Relapsed/Refractory Pediatric Solid Tumors
Children's National Research Institute
Phase 2 Completed
NCT06530784 2024-07-31
Cryoablation Combined With PD-1 Antibody and Bevacizumab for Hepatocellular Carcinoma
Shanghai Zhongshan Hospital
Phase 2 Not yet recruiting
NCT04713371 2024-05-09
A Phase 2 Trial for Patients With Metastatic Solid Cancer
Rampart Health, L.L.C.
Phase 2 Active not recruiting
NCT04118166 2023-12-12
Ipilimumab + Nivolumab + Cryotherapy in Metastatic or Locally Advanced Soft Tissue Sarcoma
Stanford University
Phase 2 Completed
NCT05893056 2023-06-27
CASTLE-09
Fudan University
Phase 2 Unknown
NCT00002997 2023-06-15
Cryosurgery in Treating Patients With Unresectable Liver Metastases From Colorectal Cancer
Eastern Cooperative Oncology Group
Phase 2 Completed
NCT02821754 2023-03-28
A Pilot Study of Combined Immune Checkpoint Inhibition in Combination With Ablative Therapies in Subjects With Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinomas (BTC)
National Institutes of Health Clinical Center (CC)
Phase 2 Completed
NCT05781074 2023-03-24
CASTLE-08
Fudan University
Phase 2 Unknown
NCT04724226 2021-09-05
C-couple
Sun Yat-sen University
Phase 2 Unknown
NCT00514215 2020-03-05
Cryotherapy and GM-CSF in Treating Patients With Lung Metastases or Primary Lung Cancer
Barbara Ann Karmanos Cancer Institute
Phase 2 Completed
NCT01986829 2018-09-19
Cryoablation, Radiofrequency Ablation, or Microwave Ablation in Treating Patients With Metastatic Sarcoma Stable on Chemotherapy
Washington University School of Medicine
Phase 2 Terminated
NCT00723294 2017-08-14
Cryoablation Therapy in Treating Patients With Invasive Ductal Breast Cancer
Alliance for Clinical Trials in Oncology
Phase 2 Unknown
NCT00922948 2016-07-27
Cryoablation Versus Radiofrequency Ablation for Small Renal Masses
St. Joseph's Healthcare Hamilton
Phase 2 Withdrawn
NCT00002655 2013-07-22
Cryosurgery in Treating Patients With Liver Cancer or Liver Metastases
University of Colorado, Denver
Phase 2 Completed