Clinical Trials Browser

OTHER × Interventional × Cryosurgery × Clear all

NCT07447414 2026-03-09

LUBRECA

Phase NA Not yet recruiting

Breast Neoplasms

NCT07450352 2026-03-04

SEED-CRYO: Sequential 125I Seed Implantation Followed by Cryoablation vs Single-Modality Local Therapy in Unresectable Solid Tumors

Phase 2 Not yet recruiting

Other solid neoplasm

Unresectable Solid Tumors

NCT07437625 2026-02-27

Lesion-Allocated Therapy for Multiple Metastases and Tumor-Zoned Treatment for Bulky Tumors: A Phase II Study of Iodine-125 Seed Implantation Combined With Cryoablation in High-Burden Metastatic Disease

Phase 2 Not yet recruiting

Other solid neoplasm

High-Burden Metastatic Solid Tumors

NCT07439432 2026-02-27

Stereotactic Guided Biopsy and Cryoablation

Phase NA Withdrawn

Breast Neoplasms

NCT04150939 2026-02-17

Cryoablation for the Treatment of Metastatic Cancer

Phase NA Active not recruiting

Neoplasm Metastasis

NCT07398118 2026-02-12

CRYO-1

Phase NA Not yet recruiting

Breast Neoplasms

NCT06593106 2026-02-02

Cryodevitalization for the Treatment of Early Stage Lung Cancer, CRYSTAL Trial

Phase NA Recruiting

Lung Neoplasms

NCT04339218 2026-01-30

CRYOMUNE

Phase 3 Recruiting

Adenocarcinoma of Lung

NCT04701918 2026-01-22

Cryoablation With Pembrolizumab Or Avelumab In Urothelial Carcinoma

Phase 2 Completed

Urinary Bladder Neoplasms, Carcinoma, Transitional Cell

NCT07232433 2026-01-22

Safety and Efficacy Evaluation of Cryoablation in the Treatment of Ground-Glass Nodules

Phase NA Recruiting

Lung Neoplasms

NCT05779423 2026-01-06

Cryoablation+Ipilimumab+Nivolumab in Melanoma

Phase 2 Recruiting

Melanoma, Skin Neoplasms

NCT07272356 2025-12-09

Evaluation of Efficacy of Minimally Invasive Local Therapy for Lung Tumors and Its Impact on Breathing Function

Phase NA Active not recruiting

Carcinoma, Non-Small-Cell Lung, Respiratory Aspiration

NCT03546686 2025-10-27

Peri-Operative Immune Checkpoint Inhibition and Cryoablation in Women With Triple-negative Breast Cancer

Phase 2 Recruiting

Breast Neoplasms

NCT04693377 2025-10-27

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

Phase NA Recruiting

DermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Melanoma, Neoplasm Metastasis, Prostatic Neoplasms, Sarcoma, Thyroid Neoplasms, Colorectal Neoplasms

NCT05806385 2025-09-09

LOGIC

Phase 1/2 Not yet recruiting

Triple Negative Breast Neoplasms

NCT05949099 2025-09-08

Study of Cryoablation and Nirogacestat for Desmoid Tumor

Phase 2 Recruiting

Desmoid Tumors

NCT07070700 2025-08-12

CASTLE-ZS-02

Phase 2 Recruiting

Gastrointestinal

Cirrhosis, Familial, with Pulmonary Hypertension, Cholangiocarcinoma

NCT06839001 2025-06-26

CRYSTAL - SIX

Phase 3 Recruiting

Breast Neoplasms

NCT03325101 2025-06-12

Dendritic Cell Therapy With Pembrolizumab for Metastatic or Unresectable Melanoma

Phase 1/2 Terminated

7 enrolled 11 charts

Melanoma

NCT06246968 2025-05-21

A Study of Pembrolizumab and Cryoablation in People With Breast Cancer

Phase 1 Recruiting

Breast Neoplasms, Triple Negative Breast Neoplasms

NCT03035331 2025-05-16

Dendritic Cell Therapy, Cryosurgery, and Pembrolizumab in Treating Patients With Non-Hodgkin Lymphoma

Phase 1/2 Completed

11 enrolled 12 charts

LymphoidOther hematologic neoplasm

Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, T-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell

NCT04522570 2025-04-30

Thermal Ablation of Cervical Metastases From Thyroid Carcinoma

Phase NA Active not recruiting

Lymphatic Metastasis, Thyroid Neoplasms, Carcinoma, Medullary

NCT05098847 2025-02-27

Cryoablation Combined with Sintilimab Plus Lenvatinib in Previously Treated Unresectable Liver Metastasis from Solid Tumors

Phase 2 Recruiting

Liver Metastasis

NCT06032845 2025-02-27

CASTLE-11

Phase 2 Recruiting

Other solid neoplasm

Solid Tumor, Adult

NCT05010668 2025-02-21

Cryoablation Combined With Sintilimab Plus Lenvatinib in Patients With Advanced Intrahepatic Cholangiocarcinoma

Phase 2 Completed

Gastrointestinal

Cholangiocarcinoma

NCT06832969 2025-02-18

A Clinical Study of the Cryoablation Technique for Peripheral Lung Malignancies

Phase NA Not yet recruiting

Lung Cancer Patients

NCT05302921 2025-01-01

Neoadjuvant Dual Checkpoint Inhibition and Cryoablation in Relapsed/Refractory Pediatric Solid Tumors

Phase 2 Completed

CNSDermatologicGastrointestinalGenitourinarySarcoma

Carcinoma, Hepatocellular, Melanoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma

NCT02833233 2024-10-23

A Study of Pre-Operative Treatment With Cryoablation and Immune Therapy in Early Stage Breast Cancer

Phase NA Completed

5 enrolled 8 charts

Breast Neoplasms

NCT06580665 2024-08-30

Cryoablation with or Without Serplulimab in Treating Patients with Stage I-IIA Non-small Cell Lung Cancer

Phase NA Not yet recruiting

Carcinoma, Non-Small-Cell Lung

NCT06530784 2024-07-31

Cryoablation Combined With PD-1 Antibody and Bevacizumab for Hepatocellular Carcinoma

Phase 2 Not yet recruiting

Gastrointestinal

Carcinoma, Hepatocellular

NCT06265350 2024-02-20

Cryoablation Combined With Cardonilizumab and Bevacizumab in Hepatocellular Carcinoma With Pulmonary Metastases

Phase NA Recruiting

Gastrointestinal

Carcinoma, Hepatocellular, Liver Neoplasms

NCT04118166 2023-12-12

Ipilimumab + Nivolumab + Cryotherapy in Metastatic or Locally Advanced Soft Tissue Sarcoma

Phase 2 Completed

30 enrolled 9 charts

Sarcoma

NCT05032079 2023-10-16

Subzero and Scorpion Trial

Phase NA Withdrawn

Carcinoma, Intraductal, Noninfiltrating

NCT03986593 2023-07-05

Cryoablation of Bone Metastases From Endocrine Tumors

Phase NA Terminated

EndocrineHead & NeckNET

Adrenal Gland Neoplasms, Neoplasm Metastasis, Pheochromocytoma, Thyroid Neoplasms, Neuroendocrine Tumors

NCT05893056 2023-06-27

CASTLE-09

Phase 2 Unknown

Gastrointestinal

Gastric Cancer Metastatic to Liver

NCT03390413 2023-06-01

ROAST

Phase NA Withdrawn

Kidney Neoplasms

NCT05781074 2023-03-24

CASTLE-08

Phase 2 Unknown

Gastrointestinal

Advanced Biliary Tract Cancer

NCT05218044 2023-03-03

DCIS

Phase NA Recruiting

Carcinoma, Intraductal, Noninfiltrating

NCT05727813 2023-02-14

To Detect Cryoimmunologic Response Induced by Early Breast Cancer Ultrasound-guided Cryoablation (ICE-study)

Phase NA Completed

Breast Neoplasms, Neoplasms, Second Primary

NCT04249167 2023-01-06

Cryoablation, Atezolizumab/Nab-paclitaxel for Locally Advanced or Metastatic Triple Negative Breast Cancer

Phase EARLY_PHASE1 Withdrawn

Triple Negative Breast Neoplasms

NCT05398497 2022-09-21

FIRST

Phase NA Unknown

Breast Neoplasms

NCT02085941 2022-08-15

Image-guided Cryoablation of Head, Neck and Spine Tumors

Phase NA Completed

30 enrolled 10 charts

Head and Neck Neoplasms, Spinal Cord Neoplasms

NCT02626130 2022-07-07

Tremelimumab With or Without Cryoablation in Treating Patients With Metastatic Kidney Cancer

Phase EARLY_PHASE1 Completed

Carcinoma, Renal Cell

NCT02489357 2021-11-12

Pembrolizumab and Cryosurgery in Treating Patients With Newly Diagnosed, Oligo-metastatic Prostate Cancer

Phase NA Completed

12 enrolled 5 charts

Prostatic Neoplasms

NCT04724226 2021-09-05

C-couple

Phase 2 Unknown

Gastrointestinal

Carcinoma, Hepatocellular

NCT04506671 2021-07-28

Percutaneous Cryoablation Versus Partial Nephrectomy for T1b Renal Tumor

Phase NA Unknown

Carcinoma, Renal Cell, Kidney Neoplasms

NCT04429204 2021-06-14

Cryoablation for the Promotion of Local Tumor Infiltration in Patients With Mesothelioma

Phase NA Withdrawn

Other solid neoplasmThoracic

Mesothelioma

NCT03189186 2021-04-05

Phase-I Trial of Pembrolizumab and Percutaneous Cryoablation Combination Followed by Nephron-Sparing Surgery or Cytoreductive Nephrectomy in Locally Advanced and Metastatic Renal Cell Carcinomas

Phase 1 Withdrawn

Carcinoma, Renal Cell, Kidney Neoplasms

NCT02736760 2020-11-09

Daylight-PDT With MAL for AK and Photodamaged Skin

Phase 4 Completed

Keratosis, Actinic

NCT02576106 2020-10-22

CRYOSE01

Phase NA Completed

Carcinoma, Ductal, Breast