Clinical Trials

70 enrolled

Recurrence, Leukemia, Myeloid, Acute

NCT02632721 2024-03-19

A Trial to Find and Investigate a Safe Dose of BI 836858 in Combination With Decitabine for Patients With Acute Myeloid Leukemia (AML)

49 enrolled 13 charts

Leukemia, Myeloid, Acute

NCT02608268 2023-12-06

Phase I-Ib/II Study of MBG453 as Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies

DermatologicGenitourinaryThoracic

252 enrolled 67 charts

Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Melanoma

NCT03593915 2023-11-09

A Phase 1b/2 Study of Alvocidib Plus Decitabine or Azacitidine in Patients With MDS

20 enrolled 13 charts

Myelodysplastic Syndromes, Neoplasms, Leukemia, Myelomonocytic, Chronic

NCT04485052 2023-10-23

Efficacy and Safety Evaluation of IBI188 in Combination With Demethylating Agents in Treatment of Patients With Acute Myeloid Leukemia

Phase 1/2 Suspended

222 enrolled

Leukemia, Myeloid, Acute

NCT03233724 2023-05-31

Oral Decitabine and Tetrahydrouridine as Epigenetic Priming for Pembrolizumab-Mediated Immune Checkpoint Blockade in Patients With Inoperable, or Unresectable Locally Advanced or Metastatic Non-Small Cell Lung Cancers and Esophageal Carcinomas

GastrointestinalOther solid neoplasmThoracic

9 enrolled 14 charts

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Lung Neoplasms

NCT02878785 2023-03-29

1565GCC

25 enrolled 6 charts

Leukemia, Myeloid, Acute

NCT03303339 2023-02-27

Onvansertib in Combination With Either Low-dose Cytarabine or Decitabine in Adult Patients With Acute Myeloid Leukemia (AML)

72 enrolled 31 charts

Leukemia, Myeloid, Acute

NCT02996474 2022-12-28

Pembrolizumab and Decitabine for Refractory or Relapsed Acute Myeloid Leukemia

10 enrolled 12 charts

Leukemia, Myeloid, Acute

NCT03709550 2022-10-05

Enzalutamide and Decitabine in Treating Patients With Metastatic Castration Resistant Prostate Cancer

Phase 1/2 Withdrawn

Genitourinary

Prostatic Neoplasms

NCT02109744 2022-07-05

AML

27 enrolled 11 charts

Leukemia, Myeloid, Acute

NCT05320640 2022-04-11

Study of Chidamide, Decitabine and Immune Checkpoint Inhibitors in R/R NHL and Advanced Solid Tumors

100 enrolled

Lymphoid

Lymphoma, Non-Hodgkin

NCT01893320 2022-02-09

Study of Vosaroxin and Decitabine in Older Patients With Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome

66 enrolled 10 charts

Leukemia, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic

NCT03113071 2021-03-16

Safety and Activity of Digoxin With Decitabine in Adult AML and MDS

1 enrolled 4 charts

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT04553393 2020-12-04

Decitabine-primed Tandem CD19/CD20 CAR T Cells Plus Epigenetic Agents in Aggressive r/r B-NHL With Huge Tumor Burden

80 enrolled

Refractory or Relapsed Aggressive r/r B-NHL With Huge Tumor Burden

NCT04493099 2020-11-12

Alvocidib in Combination With Decitabine and Venetoclax in Patients With Relapsed or Refractory AML or as Frontline Therapy in Unfit Patients With AML

Phase 1/2 Withdrawn

Leukemia, Myeloid, Acute

NCT01483690 2020-10-27

A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL

LymphoidOther hematologic neoplasm

23 enrolled 13 charts

Leukemia, Recurrence, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

NCT04582604 2020-10-20

Ruxolitinib and Decitabine for High Risk Hematological Malignancies

60 enrolled

Peripheral Blood Stem Cell Transplantation

NCT04337606 2020-04-07

Chidamide in Combination With Decitabine in Non-Hodgkin's Lymphoma Relapsed After Chimeric Antigen Receptor

Phase 1/2 Recruiting

100 enrolled

Lymphoid

Lymphoma, Non-Hodgkin

NCT02921061 2020-03-17

Decitabine With GCLAM for Adults With Newly Diagnosed, Relapsed, or Refractory AML or High-Risk MDS

28 enrolled 13 charts

Leukemia, Biphenotypic, Acute, Leukemia, Myeloid, Acute

NCT02951728 2020-03-11

DR-CHOP

58 enrolled

Lymphoid

Lymphoma, Large B-Cell, Diffuse

NCT01211457 2019-07-16

Study of Sapacitabine in Acute Myeloid Leukemia (AML) or Myelodysplastic Syndromes (MDS)

65 enrolled

Myelodysplastic Syndromes, Recurrence, Leukemia, Myeloid, Acute

NCT01794702 2019-05-30

Decitabine Followed by Clofarabine, Idarubicin, and Cytarabine in Acute Leukemia

LymphoidOther hematologic neoplasm

65 enrolled 12 charts

Leukemia, Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT01165996 2019-03-04

Differentiation Therapy With Decitabine in Treating Patients With Myelodysplastic Syndrome

Classical hematologyMyeloidOther hematologic neoplasm

25 enrolled 13 charts

Anemia, Refractory, Anemia, Refractory, with Excess of Blasts, Myelodysplastic Syndromes, Thrombocytopenia, Leukemia, Myelomonocytic, Chronic

NCT02076191 2019-02-28

Study of Combination Ruxolitinib and Decitabine Treatment for Accelerated Phase MPN or Post-MPN AML

49 enrolled

Myeloid

Myeloproliferative Disorders

NCT01729845 2019-02-07

Decitabine Followed by Mitoxantrone Hydrochloride, Etoposide, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes

52 enrolled 9 charts

Leukemia, Myeloid, Acute

NCT00075010 2018-11-15

Phase I/II Study of Decitabine and Valproic Acid in Relapsed/Refractory Leukemia or Myelodysplastic Syndromes

54 enrolled

Leukemia, Myelodysplastic Syndromes

NCT00002831 2018-10-26

Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous or Acute Leukemia

24 enrolled

Blast Crisis, Leukemia, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Acute

NCT02332889 2018-05-04

Phase I/II: Decitabine/Vaccine Therapy in Relapsed/Refractory Pediatric High Grade Gliomas/Medulloblastomas/CNS PNETs

1 enrolled 6 charts

CNS

Glioma, Medulloblastoma, Neuroectodermal Tumors, Primitive

NCT00715793 2017-10-03

UPCI-07-008

39 enrolled 12 charts

Dermatologic

Melanoma, Neoplasm Metastasis, Skin Neoplasms

NCT00925132 2017-07-02

Treatment of Resistant Metastatic Melanoma Using Decitabine, Temozolomide and Panobinostat

39 enrolled 8 charts

Dermatologic

Melanoma, Neoplasm Metastasis

NCT00691938 2016-10-13

LBH589 Plus Decitabine for Myelodysplastic Syndromes (MDS) or Acute Myeloid Leukemia (AML)

52 enrolled 18 charts

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT01628471 2015-09-23

MTD Determination, Safety and Efficacy of the Decitabine-Genistein Drug Combination in Advanced Solid Tumors and Non-Small Cell Lung Cancer

20 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT01194908 2015-01-26

Re-expression of ER in Triple Negative Breast Cancers

5 enrolled 5 charts

Breast

Breast Neoplasms

NCT00477386 2014-09-25

Trial of Decitabine as a Sensitizer to Carboplatin in Platinum Resistant Recurrent Ovarian Cancer

28 enrolled 13 charts

Gynecologic

Ovarian Neoplasms

NCT00002832 2012-07-30

Decitabine and Peripheral Stem Cell Transplantation in Treating Patients Who Have Relapsed Following Bone Marrow Transplantation for Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia