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NCT07466316 2026-03-12

A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose Chemotherapy Plus Maintenance Over a Longer Amount of Time in Patients With Newly Diagnosed Intermediate-Risk Rhabdomyosarcoma (IR RMS)

Phase 3 Not yet recruiting

Rhabdomyosarcoma

NCT05863195 2026-03-02

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

Phase 3 Recruiting

Gastrointestinal

Colorectal Neoplasms

NCT04322318 2026-02-24

A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

Phase 2 Recruiting

Wilms Tumor

NCT06620302 2026-02-24

Testing the Addition of an Anti-cancer Drug, DT2216, to the Usual Chemotherapy Treatment for Relapsed or Refractory Solid Tumors and Fibrolamellar Carcinoma

Phase 1/2 Recruiting

Gastrointestinal

Fibrolamellar hepatocellular carcinoma

NCT06998940 2026-02-20

Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations

Phase 3 Recruiting

Gastrointestinal

Pancreatic Neoplasms

NCT03794349 2026-02-18

Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma

Phase 2 Active not recruiting

94 enrolled 14 charts

Neuroblastoma

NCT03365882 2026-02-10

S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery

Phase 2 Completed

240 enrolled 14 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT04743661 2026-02-05

131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma

Phase 2 Active not recruiting

Ependymoma, Medulloblastoma

NCT07328425 2026-01-12

ISG-TULIPS

Phase 2 Recruiting

Desmoplastic Small Round Cell Tumor

NCT03533582 2025-12-22

Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery

Phase 3 Active not recruiting

Gastrointestinal

Fibrolamellar hepatocellular carcinoma, Hepatoblastoma

NCT04205968 2025-11-05

Ramucirumab and Paclitaxel or FOLFIRI in Advanced Small Bowel Cancers

Phase 2 Recruiting

Metastatic Small Intestinal Adenocarcinoma

NCT04879368 2025-07-17

INTEGRATEIIb

Phase 3 Active not recruiting

Adenocarcinoma, Carcinoma, Neoplasm Metastasis

NCT02975882 2025-01-14

Nanoparticle Albumin-Bound Rapamycin, Temozolomide, and Irinotecan Hydrochloride in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors

Phase 1 Completed

33 enrolled 15 charts

Central Nervous System Neoplasms

NCT06094140 2024-12-03

NEO-IMPACT

Phase 2 Active not recruiting

Gastrointestinal

Pancreatic Neoplasms

NCT01941316 2024-05-09

Study of Carfilzomib With Irinotecan in Irinotecan-Sensitive Malignancies and Small Cell Lung Cancer Patients

Phase 1/2 Completed

78 enrolled 15 charts

GastrointestinalGynecologicThoracic

Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Ovarian Neoplasms, Stomach Neoplasms, Small Cell Lung Carcinoma

NCT01959139 2024-02-09

S1313, PEGPH20 in Treating Patients With Newly Diagnosed Metastatic Pancreatic Cancer

Phase 1/2 Completed

126 enrolled 19 charts

Gastrointestinal

Metastatic Pancreatic Adenocarcinoma

NCT00535353 2023-08-04

AZD2281 and Irinotecan in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer

Phase 1 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00042939 2023-07-06

Irinotecan and Docetaxel With or Without Cetuximab in Treating Patients With Metastatic Pancreatic Cancer

Phase 2 Completed

94 enrolled 10 charts

Gastrointestinal

Pancreatic Neoplasms

NCT00057837 2023-07-05

Comparison of Two Combination Chemotherapy Regimens in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Phase 2 Completed

140 enrolled 8 charts

Extensive Stage Small Cell Lung Cancer

NCT00098787 2023-07-05

Bevacizumab and Oxaliplatin Combined With Irinotecan or Leucovorin and Fluorouracil in Treating Patients With Metastatic or Recurrent Colorectal Cancer

Phase 2 Completed

247 enrolled 10 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00033657 2023-06-28

Radiation Therapy and Chemotherapy Before and After Surgery in Treating Patients With Esophageal Cancer

Phase 2 Completed

97 enrolled 9 charts

Gastrointestinal

Adenocarcinoma Of Esophagus, Esophageal Neoplasms, Stomach Neoplasms

NCT01079780 2023-06-28

Irinotecan Hydrochloride and Cetuximab With or Without Ramucirumab in Treating Patients With Advanced Colorectal Cancer With Progressive Disease After Treatment With Bevacizumab-Containing Chemotherapy

Phase 2 Completed

136 enrolled 13 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00354835 2023-01-31

Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma

Phase 3 Completed

481 enrolled 21 charts

Rhabdomyosarcoma, Sarcoma

NCT02562716 2022-10-19

S1505: Combination Chemotherapy or Gemcitabine Hydrochloride and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Before Surgery in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery

Phase 2 Completed

147 enrolled 16 charts

Gastrointestinal

Pancreatic Adenocarcinoma

NCT02727387 2022-09-19

EW-2

Phase 2 Completed

Sarcoma, Ewing

NCT04089150 2021-10-22

MASTERPLAN

Phase 2 Unknown

Gastrointestinal

Pancreatic Neoplasms

NCT00314353 2021-10-06

Study of Bevacizumab Combined With Capecitabine and Either Oxaliplatin or Irinotecan as First Course of Treatment for Patients With Colorectal Cancer That Has Spread Beyond the Colon

Phase 2 Terminated

7 enrolled 5 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00023868 2020-12-02

Combination Chemotherapy With or Without Chemoembolization in Treating Patients With Colorectal Cancer Metastatic to the Liver (6655)

Phase 3 Terminated

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00006366 2020-10-22

Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum

Phase 2 Completed

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT00081289 2020-02-27

Neoadjuvant Chemoradiotherapy and Adjuvant Chemotherapy in Treating Patients Who Are Undergoing Surgical Resection for Locally Advanced Rectal Cancer

Phase 2 Completed

146 enrolled 23 charts

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT00354744 2020-01-29

High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma

Phase 3 Completed

109 enrolled 12 charts

Malignant mesenchymal tumor, Rhabdomyosarcoma, Sarcoma

NCT01498289 2019-11-07

S1201: Combination Chemo for Patients W/Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction Cancer

Phase 2 Completed

213 enrolled 17 charts

Gastrointestinal

Adenocarcinoma Of Esophagus, Esophageal Neoplasms, Stomach Neoplasms

NCT00045162 2018-07-31

S0124: Cisplatin Combined With Irinotecan or Etoposide For Extensive-Stage Small Cell Lung Cancer

Phase 3 Completed

671 enrolled 10 charts

Lung Neoplasms

NCT00335556 2017-07-21

Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors

Phase 2 Completed

291 enrolled 18 charts

Carcinoma, Renal Cell, Wilms Tumor

NCT00109850 2015-11-18

S0414 Cetuximab, Combo Chemo, and RT in Locally Advanced Esophageal Cancer

Phase 2 Terminated

22 enrolled 9 charts

Gastrointestinal

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms

NCT00059761 2015-11-17

Chemotherapy Combined With Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer

Phase 1 Completed

Lung Neoplasms

NCT00003843 2015-02-16

Irinotecan in Treating Patients With Colorectal Cancer

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00311584 2014-09-30

Irinotecan and Temozolomide in Treating Young Patients With Recurrent Neuroblastoma

Phase 2 Completed

59 enrolled 10 charts

Neuroblastoma

NCT00006095 2014-02-21

Combination Chemotherapy in Treating Children With Solid Tumors That Have Not Responded to Previous Therapy

Phase 1 Completed

Other solid neoplasm

Unspecified Childhood Solid Tumor, Protocol Specific

NCT00003955 2014-02-14

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Metastatic Rhabdomyosarcoma or Sarcoma

Phase 2 Completed

Malignant mesenchymal tumor, Rhabdomyosarcoma, Sarcoma

NCT00099125 2014-01-24

Radiation Therapy, Temozolomide, and Irinotecan in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Phase 2 Completed

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00004078 2013-06-14

Irinotecan in Treating Children With Refractory Solid Tumors

Phase 2 Completed

Familial ependymoma, Astrocytoma, Medulloblastoma, Neuroblastoma, Oligodendroglioma, Osteosarcoma, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Optic Nerve Glioma

NCT00030433 2013-02-15

S0119: Combination Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Phase 2 Completed

Lung Neoplasms

NCT00066612 2012-11-02

S0306, Irinotecan in Treating Patients With Recurrent or Refractory Advanced Transitional Cell Cancer of the Urothelium Previously Treated With Chemotherapy

Phase 2 Completed

Urinary Bladder Neoplasms, Urethral Neoplasms

NCT00004885 2012-09-24

Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients With Metastatic Colorectal Cancer

Phase 3 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00064181 2012-09-24

Combination Chemotherapy With or Without Celecoxib in Treating Patients With Metastatic Colorectal Cancer

Phase 3 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00066391 2012-09-24

Irinotecan and Cisplatin in Treating Patients With Locally Advanced or Metastatic Penile Cancer

Phase 2 Completed

Penile Neoplasms

NCT00039208 2012-07-13

Combination Chemotherapy in Treating Patients With Colorectal Cancer

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00012363 2012-06-14

S0101 Gemcitabine and Irinotecan in Treating Patients With Metastatic or Recurrent Cancer of the Esophagus

Phase 2 Completed

Gastrointestinal

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms, Stomach Neoplasms

NCT00070434 2012-06-07

S0304 Induct Chemo Then Chemo-RT in Pts w/Locally Advanced Adenocarcinoma of the Rectum

Phase 2 Withdrawn

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms