Clinical Trials

608 enrolled 17 charts

Breast Neoplasms

NCT00680901 2025-08-07

LOGiC - Lapatinib Optimization Study in ErbB2 (HER2) Positive Gastric Cancer: A Phase III Global, Blinded Study Designed to Evaluate Clinical Endpoints and Safety of Chemotherapy Plus Lapatinib

545 enrolled 24 charts

Gastrointestinal

Esophageal Neoplasms, Neoplasm Metastasis, Neoplasms

NCT00490139 2025-03-21

ALTTO

8,381 enrolled 22 charts

Breast Neoplasms

NCT00667251 2025-03-21

Chemotherapy and Lapatinib or Trastuzumab in Treating Women With HER2/Neu-Positive Metastatic Breast Cancer

652 enrolled 50 charts

Breast Neoplasms

NCT01160211 2025-03-07

A Study to Compare the Safety and Efficacy of an Aromatase Inhibitor in Combination With Lapatinib, Trastuzumab or Both for the Treatment of Hormone Receptor Positive, HER2+ Metastatic Breast Cancer

369 enrolled 19 charts

Breast Neoplasms

NCT00963547 2024-06-04

MK-2206-015

Phase 1 Terminated

33 enrolled 13 charts

Breast Neoplasms

NCT01199367 2024-04-25

Safety, Tolerability, and Efficacy Study in Subjects With Advanced or Metastatic Breast Cancer

Phase 1 Terminated

11 enrolled

Breast Neoplasms

NCT03500380 2024-02-20

A Study of RC48-ADC Administered Intravenously to Patients With HER2-Positive Metastatic Breast Cancer With or Without Liver Metastases

Phase 2/3 Unknown

301 enrolled

Breast Diseases, Breast Neoplasms

NCT03084939 2023-05-06

Efficacy and Safety of Trastuzumab Emtansine in Chinese Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Locally Advanced or Metastatic Breast Cancer

351 enrolled

Breast Neoplasms

NCT00272987 2023-04-28

ErbB2 Over-expressing Metastatic Breast Cancer Study Using Paclitaxel, Trastuzumab, and Lapatinib

Phase 3 Terminated

63 enrolled 22 charts

Breast Neoplasms

NCT00251433 2023-03-31

GW572016 With Docetaxel and Trastuzumab for the Treatment Of Untreated ErbB2 Over-Expressing Metastatic Breast Cancer

Phase 1 Terminated

53 enrolled

Breast Neoplasms

NCT00807859 2022-11-08

Safety Study of AMG 386 to Treat HER2-positive Locally Recurrent or Metastatic Breast Cancer

65 enrolled

Breast Neoplasms, Neoplasm Metastasis, Neoplasms

NCT00444535 2021-10-25

Lapatinib and Bevacizumab for Metastatic Breast Cancer

52 enrolled 13 charts

Breast Neoplasms, Osteitis Deformans

NCT00508274 2021-09-21

Lapatinib +Capecitabine Treatment for Advanced Metastatic Breast Cancer in Women From China

Phase 3 Terminated

52 enrolled 12 charts

Breast Neoplasms

NCT00553358 2021-09-21

Neo ALTTO

455 enrolled 34 charts

Breast Neoplasms, Osteitis Deformans

NCT01808573 2021-06-11

NALA

621 enrolled 21 charts 2 FDA

HER2+ Metastatic Breast Cancer (MBC)

NCT00073528 2021-02-24

Study Comparing Lapatinib (GW572016) And Letrozole Versus Letrozole In Subjects With Advanced Or Metastatic Breast Cancer

1,286 enrolled 41 charts

Breast Neoplasms

NCT00367471 2020-09-09

Combination Of Lapatinib With Carboplatin, Paclitaxel, and With or Without Trastuzumab In Metastatic Breast Cancer.

31 enrolled

Breast Neoplasms, Neoplasm Metastasis

NCT03080805 2020-06-18

Pyrotinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in Patients With HER2+ Metastatic Breast Cancer. (PHOEBE)

Phase 3 Unknown

240 enrolled

HER2 Positive Metastatic Breast Cancer

NCT00263588 2019-12-12

Lapatinib for Brain Metastases In ErbB2-Positive Breast Cancer

242 enrolled 19 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms, Neoplasms

NCT04185649 2019-12-04

The Efficacy and Safety of BAT8001 Injection for the Treatment of HER2-positive Advanced Breast Cancer

Phase 3 Unknown

410 enrolled

HER2-positive Advanced Breast Cancer

NCT02294786 2019-07-15

Study of Prophylactic Octreotide to Prevent or Reduce the Frequency and Severity of Diarrhoea in Subjects Receiving Lapatinib With Capecitabine for the Treatment of Metastatic Breast Cancer

Phase 2 Terminated

62 enrolled 25 charts

Breast Neoplasms, Diarrhea, Neoplasms

NCT00968968 2019-06-10

Continued HER2 Suppression With Lapatinib Plus Trastuzumab Versus Trastuzumab Alone

Phase 3 Terminated

37 enrolled 11 charts

Tumor-Agnostic

Carcinoma, Neoplasms

NCT00820222 2019-04-02

Lapatinib Plus Capecitabine Versus Trastuzumab Plus Capecitabine in ErbB2 (HER2) Positive Metastatic Breast Cancer

540 enrolled 18 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT00320411 2019-01-31

GW572016 In Patients With ErbB2 Over - Expressing Advanced Or Metastatic Breast Cancer

62 enrolled 24 charts

Breast Neoplasms

NCT00477464 2018-09-17

Lapatinib in Combination With Capecitabine in Japanese Patients With Metastatic Breast Cancer

51 enrolled 25 charts

Breast Neoplasms

NCT00371488 2018-08-31

GW572016 Combined With Trastuzumab For The Treatment Of Previously Trastuzumab-Treated Breast Cancer

11 enrolled

Breast Neoplasms

NCT00462956 2018-08-31

GW572016 In Patients With Advanced Or Metastatic Breast Cancer

59 enrolled

Breast Neoplasms

NCT00777101 2018-08-09

Study Evaluating Neratinib Versus Lapatinib Plus Capecitabine For ErbB2 Positive Advanced Breast Cancer

233 enrolled 16 charts

Breast Neoplasms, Neoplasm Metastasis

NCT00790816 2018-02-28

Continuation Study of Lapatinib Monotherapy or Lapatinib in Combination With Other Anti-cancer Agents

500 enrolled

Breast Neoplasms, Neoplasms

NCT00536809 2017-12-18

Phase I/II Study of Lapatinib in Combination With Oxaliplatin and Capecitabine in Subjects With Advanced Colorectal Cancer

12 enrolled 6 charts

Gastrointestinal

Colorectal Neoplasms

NCT00148902 2017-12-06

Effects Of GW572016 In Combination With Docetaxel (TAXOTERE)

52 enrolled

Breast Neoplasms, Neoplasms

NCT00258050 2017-12-06

To Examine The Effects Of Lapatinib On Orally And Intravenously Administered Midazolam In Cancer Patients

24 enrolled

Breast Neoplasms

NCT00158782 2017-11-17

Study Of Safety And Tolerability Of GW786034 Given With Lapatinib In Cancer Patients

75 enrolled

Genitourinary

Carcinoma, Renal Cell

NCT00169533 2017-11-17

Rollover Study Of Lapatinib In Cancer Patients

31 enrolled

Breast Neoplasms

NCT00388076 2017-11-17

Pazopanib (VOTRIENT) Plus Paclitaxel (TAXOL), Pazopanib Plus Paclitaxel (TAXOL) Plus Carboplatin (PARAPLATIN), and Pazopanib Plus Paclitaxel (TAXOL) Plus Lapatinib (TYKERB)

86 enrolled

Breast Neoplasms

NCT00528281 2017-11-17

A Phase II Trial of Lapatinib (TYKERB) + Pemetrexed (ALIMTA) in Advanced Non Small Cell Lung Cancer With an Initial Dose Finding Phase

18 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT00650910 2017-11-17

Study To Examine The Effects Of Lapatinib On The Pharmacokinetics Of Digoxin In Subjects w/ ErbB2 Positive Breast Cancer

17 enrolled

Breast Neoplasms

NCT00849329 2017-11-14

A Study to Examine the Effects of Esomeprazole on the Pharmacokinetics of Orally Administered Lapatinib in Subjects With Metastatic ErbB2 Positive Breast Cancer

12 enrolled

Breast Neoplasms

NCT00359190 2017-11-13

Pharmacokinetics And Pharmacodynamics Of Lapatinib In Two Dosing Regimens In Treatment-naive Patients With Breast Cancer

28 enrolled

Breast Neoplasms

NCT00516672 2017-11-13

Phase I Study of Pazopanib Alone and In Combination With Lapatinib in Japanese Patients With Solid Tumors

30 enrolled

Genitourinary

Carcinoma, Renal Cell, Neoplasms

NCT00821054 2017-11-13

A Study to Examine the Effects of Low and High-fat Meals on Orally Administered Lapatinib in Metastatic ErbB2 Positive Breast Cancer Patients

24 enrolled

Breast Neoplasms

NCT00996762 2017-11-13

A Study in Cancer Patients to Evaluate the Bioequivalence of Alternative Formulations of Lapatinib

158 enrolled

Breast Neoplasms

NCT01290354 2017-11-13

Exploratory Lapatinib (Positron Emission Tomography) PET Study in Subjects With Breast Cancer

10 enrolled

Tumor-Agnostic

Neoplasms

NCT01205217 2017-06-07

ELATE

Phase 2 Withdrawn

Breast Neoplasms

NCT00111787 2017-05-31

Study Of Lapatinib In Combination With Paclitaxel In The Treatment Of Newly Diagnosed Inflammatory Breast Cancer

49 enrolled

Breast Neoplasms

NCT01013740 2017-05-31

VITAL

112 enrolled 15 charts

Breast Neoplasms, Neoplasms

NCT00089999 2017-02-28

Lapatinib In Chemotherapy-Naive Or Metastatic Breast Cancer

138 enrolled 16 charts

Breast Neoplasms

NCT00524303 2016-11-11

Lapatinib +/- Trastuzumab In Addition To Standard Neoadjuvant Breast Cancer Therapy.

100 enrolled 14 charts

Breast Neoplasms

NCT00829166 2016-10-31

EMILIA

991 enrolled 26 charts