Clinical Trials Browser

Breast Neoplasms, Colonic Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Endometrial Neoplasms

NCT06537843 2024-08-05

VenCM

Phase 2 Recruiting

100 enrolled

Other hematologic neoplasm

Leukemia, Myeloid, Acute

NCT02523898 2024-04-25

Metformine and CC Compared With Placebo and CC for Induction Ovulation in PCOS Patients With Insulin Resistant

Phase 2 Terminated

388 enrolled

Infertility, Polycystic Ovary Syndrome, Hyperandrogenism

NCT01996696 2024-01-30

PREMIUM

Phase 2 Terminated

83 enrolled

Genitourinary

Prostatic Neoplasms, Weight Gain, Metabolic Syndrome

NCT04033107 2023-09-28

High Dose Vitamin C Combined With Metformin in the Treatment of Malignant Tumors

Phase 2 Unknown

30 enrolled

Gastrointestinal

Liver Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT03379909 2023-09-21

TROJAN

Phase 2 Recruiting

49 enrolled

Genitourinary

Non-Muscle Invasive Bladder Neoplasms, Urinary Bladder Neoplasms

NCT04758000 2023-08-04

Metform-Bone

Phase 2 Recruiting

67 enrolled

Sarcoma

Sarcoma, Ewing, Osteosarcoma

NCT02028221 2023-06-27

Phase II Study of Metformin for Reduction of Obesity-Associated Breast Cancer Risk

Phase 2 Completed

151 enrolled 15 charts

Breast

Breast Cancer Prevention

NCT02640534 2023-06-27

Investigation of Metformin in Patients With Castration Resistant Prostate Cancer in Combination With Enzalutamide vs. Enzalutamide Alone

Phase 2 Terminated

169 enrolled

Genitourinary

Prostatic Neoplasms

NCT05351021 2023-03-09

Efficacy of Metformin as Preventive Treatment in Paclitaxel Induced Peripheral Neuropathy in Breast Cancer Patients

Phase 2 Completed

76 enrolled

Breast

Breast Neoplasms, Peripheral Nervous System Diseases

NCT04248998 2023-01-18

BREAKFAST

Phase 2 Unknown

30 enrolled

Breast

Triple Negative Breast Neoplasms

NCT02874430 2022-12-15

Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer

Phase 2 Unknown

27 enrolled

Breast

Breast Neoplasms

NCT03200015 2022-11-07

Rituximab, Cyclophosphamide, Vincristine and Prednisone (R-CHOP) Plus Metformin in Diffuse Large-B-cell Lymphoma

Phase 2 Completed

15 enrolled

Lymphoid

Lymphoma, Large B-Cell, Diffuse

Clinical Trials

Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion

METCAP

PNOC041

Study of Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients Receiving Androgen Deprivation Therapy

Metformin Hydrochloride in Combination With Standard of Care Systemic Therapy in Previously Untreated Advanced Unresectable or Metastatic Soft Tissue Sarcoma

Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma

Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia

An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer

Metformin and Nightly Fasting in Women With Early Breast Cancer

Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients

A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging

Paxalisib With a High Fat, Low Carb Diet and Metformin for Glioblastoma

Metformin to Mitigate Sequelae of Radioactive Iodine Treatment for Thyroid Cancers

A Phase II, Single-Arm Study of RAD001 (Everolimus), Letrozole, and Metformin in Patients With Advanced or Recurrent Endometrial Carcinoma

An Open-Label Pilot Intervention Trial to Prevent Diabetes in Prediabetic Adult Survivors of Childhood Cancer

Chemotherapy and Radiation Therapy With or Without Metformin Hydrochloride in Treating Patients With Stage III Non-small Cell Lung Cancer

Metformin for Chemoprevention of Lung Cancer in Overweight or Obese Individuals at High Risk for Lung Cancer

Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia

A Pilot Study of Metformin Therapy in Patients With Relapsed Chronic Lymphocytic Leukemia (CLL) and Untreated CLL

METALLICA

Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma

MEMENTO

Metformin, Neo-adjuvant Temozolomide and Hypo- Accelerated Radiotherapy Followed by Adjuvant TMZ in Patients With GBM

RESOLVE: Abemaciclib + Letrozole +/- Metformin, Zotatifin, or Gedatolisib in Endometrial or Low-Grade Serous Ovarian Cancer

Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

NivoMet

Metformin for the Treatment of mCRC Patients Undergoing FOLFIRI Plus Target Therapy

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

met-HEReMYTA

ASAMET

METOXY-LACC

Metformin With the Levonorgestrel-Releasing Intrauterine Device for the Treatment of Complex Atypical Hyperplasia (CAH) and Endometrial Cancer (EC) in Non-surgical Patients

Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS

PIAII

CPI-613 Given With Metformin in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML)

Nivolumab and Metformin in Patients With Treatment Refractory MSS Colorectal Cancer

feMMe

SPIRIT

VenCM

Metformine and CC Compared With Placebo and CC for Induction Ovulation in PCOS Patients With Insulin Resistant

PREMIUM

High Dose Vitamin C Combined With Metformin in the Treatment of Malignant Tumors

TROJAN

Metform-Bone

Phase II Study of Metformin for Reduction of Obesity-Associated Breast Cancer Risk

Investigation of Metformin in Patients With Castration Resistant Prostate Cancer in Combination With Enzalutamide vs. Enzalutamide Alone

Efficacy of Metformin as Preventive Treatment in Paclitaxel Induced Peripheral Neuropathy in Breast Cancer Patients

BREAKFAST

Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer

Rituximab, Cyclophosphamide, Vincristine and Prednisone (R-CHOP) Plus Metformin in Diffuse Large-B-cell Lymphoma