Clinical Trials Browser

Posterior Fossa Ependymal Tumor

NCT07291297 2026-03-05

Metformin Hydrochloride in Combination With Standard of Care Systemic Therapy in Previously Untreated Advanced Unresectable or Metastatic Soft Tissue Sarcoma

Phase 2 Recruiting

50 enrolled

Sarcoma

NCT07387900 2026-02-06

Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia

Phase 2 Recruiting

34 enrolled

Head & Neck

Leukoplakia, Oral

NCT06763328 2026-01-22

Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy

Phase 3 Recruiting

200 enrolled

Breast

Anatomic Stage I Breast Cancer AJCC v8

NCT06044025 2026-01-15

A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy

Phase 1 Recruiting

34 enrolled

Genitourinary

Castration Sensitive Prostate Cancer

NCT05515978 2025-12-04

PragMet

Phase EARLY_PHASE1 Recruiting

100 enrolled

Genitourinary

Neoplasms, Prostatic Neoplasms

NCT07098299 2025-11-06

Metformin Combined With Chemotherapy and/or Immunotherapy in Solid Malignancies

Phase 1 Recruiting

60 enrolled

Other solid neoplasm

Advanced Solid Tumor

NCT05036226 2025-10-06

COAST

Phase 1/2 Recruiting

76 enrolled

GenitourinaryOther solid neoplasm

Prostate Cancer Recurrent

NCT05929495 2025-07-25

Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma

Phase 2 Recruiting

25 enrolled

CNS

Glioblastoma, Glioma, Neoplasms

NCT06687876 2025-07-10

MEMENTO

Phase 2 Recruiting

14 enrolled

Gastrointestinal

Adenocarcinoma Of Esophagus, Adenocarcinoma, Esophageal Neoplasms

NCT03675893 2025-06-15

RESOLVE: Abemaciclib + Letrozole +/- Metformin, Zotatifin, or Gedatolisib in Endometrial or Low-Grade Serous Ovarian Cancer

Phase 2 Recruiting

180 enrolled

Gynecologic

Ovarian Neoplasms, Endometrial Neoplasms

NCT06742710 2025-05-29

LITOP

Phase 4 Recruiting

890 enrolled

Other

Infertility, Obesity, Polycystic Ovary Syndrome

NCT03311308 2025-05-06

A Trial of Pembrolizumab and Metformin Versus Pembrolizumab Alone in Advanced Melanoma

Phase 1 Recruiting

30 enrolled

Dermatologic

Melanoma

NCT06896981 2025-04-02

Semaglutide in Women With Polycystic Ovary Syndrome and Obesity

Phase 2/3 Recruiting

30 enrolled

Other

Obesity, Polycystic Ovary Syndrome

NCT06826092 2025-02-13

Metformin for the Treatment of mCRC Patients Undergoing FOLFIRI Plus Target Therapy

Phase 2 Recruiting

110 enrolled

Progression-Free Survival

NCT04114136 2025-02-10

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

Phase 2 Recruiting

72 enrolled

DermatologicGastrointestinalHead & Neck

Adenocarcinoma Of Esophagus, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hepatocellular, Melanoma

NCT04741945 2024-11-22

Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS

Phase 2 Recruiting

40 enrolled

Classical hematologyOther hematologic neoplasm

Cytopenia, Anemia, Refractory, with Excess of Blasts, Preleukemia

NCT06576375 2024-10-22

Efficacy of Dapagliflozin Versus Metformin in Polycystic Ovary Syndrome

Phase 3 Recruiting

70 enrolled

Polycystic Ovary Syndrome

NCT02647827 2024-10-09

PIAII

Phase 2 Recruiting

303 enrolled

Insulin Resistance, Polycystic Ovary Syndrome, Hyperandrogenism

NCT06215976 2024-08-20

The Nephroprotective Effect of Metformin With Cisplatin in Bladder Cancer

Phase 4 Recruiting

78 enrolled

Genitourinary

Urinary Bladder Neoplasms

NCT06537843 2024-08-05

VenCM

Phase 2 Recruiting

100 enrolled

Other hematologic neoplasm

Leukemia, Myeloid, Acute

NCT06030622 2024-04-19

C3

Phase 1/2 Recruiting

25 enrolled

Gastrointestinal

Pancreatic Neoplasms

NCT05702905 2024-03-25

Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome

Phase 4 Recruiting

75 enrolled

Other

Obesity, Polycystic Ovary Syndrome

NCT03379909 2023-09-21

TROJAN

Phase 2 Recruiting

49 enrolled

Genitourinary

Non-Muscle Invasive Bladder Neoplasms, Urinary Bladder Neoplasms

NCT04758000 2023-08-04

Metform-Bone

Phase 2 Recruiting

67 enrolled

Sarcoma

Sarcoma, Ewing, Osteosarcoma

NCT01638676 2021-10-29

A Phase I/II Trial of Vemurafenib and Metformin to Melanoma Patients

Phase 1/2 Recruiting

55 enrolled

Dermatologic

Melanoma

Clinical Trials

PNOC041

Metformin Hydrochloride in Combination With Standard of Care Systemic Therapy in Previously Untreated Advanced Unresectable or Metastatic Soft Tissue Sarcoma

Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia

Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy

A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy

PragMet

Metformin Combined With Chemotherapy and/or Immunotherapy in Solid Malignancies

COAST

Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma

MEMENTO

RESOLVE: Abemaciclib + Letrozole +/- Metformin, Zotatifin, or Gedatolisib in Endometrial or Low-Grade Serous Ovarian Cancer

LITOP

A Trial of Pembrolizumab and Metformin Versus Pembrolizumab Alone in Advanced Melanoma

Semaglutide in Women With Polycystic Ovary Syndrome and Obesity

Metformin for the Treatment of mCRC Patients Undergoing FOLFIRI Plus Target Therapy

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS

Efficacy of Dapagliflozin Versus Metformin in Polycystic Ovary Syndrome

PIAII

The Nephroprotective Effect of Metformin With Cisplatin in Bladder Cancer

VenCM

C3

Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome

TROJAN

Metform-Bone

A Phase I/II Trial of Vemurafenib and Metformin to Melanoma Patients