Clinical Trials

30 enrolled

Posterior Fossa Ependymal Tumor

NCT07372625 2026-03-12

A Study to Investigate the Effects of Multiple Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation.

14 enrolled

Other solid neoplasm

TP53 Y220C Mutation

NCT07291297 2026-03-05

Metformin Hydrochloride in Combination With Standard of Care Systemic Therapy in Previously Untreated Advanced Unresectable or Metastatic Soft Tissue Sarcoma

50 enrolled

Sarcoma

NCT07399535 2026-02-10

PCOS

116 enrolled

Infertility, Metabolic Diseases, Polycystic Ovary Syndrome

NCT07387900 2026-02-06

Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia

34 enrolled

Head & Neck

Leukoplakia, Oral

NCT06763328 2026-01-22

Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy

Phase 3 Recruiting

200 enrolled

Breast

Anatomic Stage I Breast Cancer AJCC v8

NCT06044025 2026-01-15

A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy

34 enrolled

Phase EARLY_PHASE1 Recruiting

Castration Sensitive Prostate Cancer

NCT05515978 2025-12-04

PragMet

100 enrolled

Neoplasms, Prostatic Neoplasms

NCT07098299 2025-11-06

Metformin Combined With Chemotherapy and/or Immunotherapy in Solid Malignancies

GenitourinaryOther solid neoplasm

60 enrolled

Other solid neoplasm

Advanced Solid Tumor

NCT05036226 2025-10-06

COAST

Phase 1/2 Recruiting

76 enrolled

Prostate Cancer Recurrent

NCT05929495 2025-07-25

Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma

25 enrolled

CNS

Glioblastoma, Glioma, Neoplasms

NCT06687876 2025-07-10

MEMENTO

14 enrolled

Gastrointestinal

Adenocarcinoma Of Esophagus, Adenocarcinoma, Esophageal Neoplasms

NCT03675893 2025-06-15

RESOLVE: Abemaciclib + Letrozole +/- Metformin, Zotatifin, or Gedatolisib in Endometrial or Low-Grade Serous Ovarian Cancer

180 enrolled

Gynecologic

Ovarian Neoplasms, Endometrial Neoplasms

NCT06742710 2025-05-29

LITOP

Phase 4 Recruiting

890 enrolled

Other

Infertility, Obesity, Polycystic Ovary Syndrome

NCT03311308 2025-05-06

A Trial of Pembrolizumab and Metformin Versus Pembrolizumab Alone in Advanced Melanoma

30 enrolled

Dermatologic

Melanoma

NCT06896981 2025-04-02

Semaglutide in Women With Polycystic Ovary Syndrome and Obesity

Phase 2/3 Recruiting

30 enrolled

Other

Obesity, Polycystic Ovary Syndrome

NCT06826092 2025-02-13

Metformin for the Treatment of mCRC Patients Undergoing FOLFIRI Plus Target Therapy

110 enrolled

Progression-Free Survival

NCT04114136 2025-02-10

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

DermatologicGastrointestinalHead & Neck

72 enrolled

Adenocarcinoma Of Esophagus, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hepatocellular, Melanoma

NCT04741945 2024-11-22

Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS

Classical hematologyOther hematologic neoplasm

40 enrolled

Cytopenia, Anemia, Refractory, with Excess of Blasts, Preleukemia

NCT06576375 2024-10-22

Efficacy of Dapagliflozin Versus Metformin in Polycystic Ovary Syndrome

Phase 3 Recruiting

70 enrolled

Polycystic Ovary Syndrome

NCT02647827 2024-10-09

PIAII

303 enrolled

Insulin Resistance, Polycystic Ovary Syndrome, Hyperandrogenism

NCT06215976 2024-08-20

The Nephroprotective Effect of Metformin With Cisplatin in Bladder Cancer

Phase 4 Recruiting

78 enrolled

Urinary Bladder Neoplasms

NCT06537843 2024-08-05

VenCM

Other hematologic neoplasm

100 enrolled

Leukemia, Myeloid, Acute

NCT06030622 2024-04-19

C3

Phase 1/2 Recruiting

25 enrolled

Gastrointestinal

Pancreatic Neoplasms

NCT05702905 2024-03-25

Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome

Phase 4 Recruiting

75 enrolled

Other

Obesity, Polycystic Ovary Syndrome

NCT03379909 2023-09-21

TROJAN

49 enrolled

Non-Muscle Invasive Bladder Neoplasms, Urinary Bladder Neoplasms

NCT04758000 2023-08-04

Metform-Bone