NCT02581137 2026-03-18
Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion
National Cancer Institute (NCI)
Phase 2 Active not recruiting
Clinical Trials
335 trialsNCT02437656 2026-03-16
METCAP
Centre Oscar Lambret
Phase 2 Completed
NCT03424005 2026-03-16
Morpheus-panBC
Hoffmann-La Roche
Phase 1/2 Recruiting
NCT07226453 2026-03-13
PNOC041
University of California, San Francisco
Phase 2 Recruiting
NCT07372625 2026-03-12
A Study to Investigate the Effects of Multiple Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation.
PMV Pharmaceuticals, Inc
Phase 1 Recruiting
NCT03006172 2026-03-11
To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer
Genentech, Inc.
Phase 1 Active not recruiting
NCT07459595 2026-03-10
Metformin Versus Myo-inositol in the Management of Polycystic Ovarian Disease: A Comparative Study
Combined Military Hospital Gujranwala
Phase 1 Not yet recruiting
NCT05965908 2026-03-06
Effect of Liraglutide in Obese Women With Polycystic Ovary Syndrome
Beni-Suef University
Phase 3 Completed
NCT02946996 2026-03-05
Study of Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients Receiving Androgen Deprivation Therapy
Medical University of South Carolina
Phase 2 Terminated
NCT07291297 2026-03-05
Metformin Hydrochloride in Combination With Standard of Care Systemic Therapy in Previously Untreated Advanced Unresectable or Metastatic Soft Tissue Sarcoma
Wake Forest University Health Sciences
Phase 2 Recruiting
NCT06899061 2026-03-03
Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saruparib
AstraZeneca
Phase 1 Active not recruiting
NCT03905941 2026-02-23
SHK002
University of Virginia
Phase EARLY_PHASE1 Withdrawn
NCT07399535 2026-02-10
PCOS
Jinnah Postgraduate Medical Centre
Phase 1 Recruiting
NCT04850846 2026-02-09
Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma
Dana-Farber Cancer Institute
Phase 2 Active not recruiting
NCT05767515 2026-02-09
PCOS
Khyber Medical University Peshawar
Phase NA Completed
NCT07387900 2026-02-06
Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia
Cairo University
Phase 2 Recruiting
NCT02336087 2026-02-04
Gemcitabine Hydrochloride, Paclitaxel Albumin-Stabilized Nanoparticle Formulation, Metformin Hydrochloride, and a Standardized Dietary Supplement in Treating Patients With Pancreatic Cancer That Cannot be Removed by Surgery
City of Hope Medical Center
Phase 1 Active not recruiting
NCT07387679 2026-02-04
Myo-inositol Versus Metformin in Patients With Polycystic Ovarian Syndrome to Treat Obesity
RESnTEC, Institute of Research
Phase NA Completed
NCT07380841 2026-02-02
PCOS-COMBO (9)
Islamabad Medical and Dental College
Phase NA Completed
NCT02365597 2026-01-30
An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer
Janssen Research & Development, LLC
Phase 2 Active not recruiting
NCT06763328 2026-01-22
Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy
City of Hope Medical Center
Phase 3 Recruiting
NCT06044025 2026-01-15
A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy
University of Arkansas
Phase 1 Recruiting
NCT07323589 2026-01-07
Impact of Myo-Inositol Alone vs Myo-Inositol Plus Metformin on Conception, Adherence, and Tolerability in PCOS
PAEC general hospital
Phase 3 Completed
NCT05023967 2026-01-05
Metformin and Nightly Fasting in Women With Early Breast Cancer
M.D. Anderson Cancer Center
Phase 2 Active not recruiting
NCT04414540 2025-12-19
Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients
University of Cincinnati
Phase 2 Active not recruiting
NCT04691960 2025-12-19
A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging
Weill Medical College of Cornell University
Phase 2 Active not recruiting
NCT05183204 2025-12-18
Paxalisib With a High Fat, Low Carb Diet and Metformin for Glioblastoma
Weill Medical College of Cornell University
Phase 2 Suspended
NCT03109847 2025-12-11
Metformin to Mitigate Sequelae of Radioactive Iodine Treatment for Thyroid Cancers
Thomas Jefferson University
Phase 2 Terminated
NCT05515978 2025-12-04
PragMet
University of Colorado, Denver
Phase EARLY_PHASE1 Recruiting
NCT05802212 2025-11-25
Effect of Metformin on Patients With Polycystic Ovary Syndrome
Peking University Third Hospital
Phase NA Completed
NCT01797523 2025-11-06
A Phase II, Single-Arm Study of RAD001 (Everolimus), Letrozole, and Metformin in Patients With Advanced or Recurrent Endometrial Carcinoma
M.D. Anderson Cancer Center
Phase 2 Active not recruiting
NCT07098299 2025-11-06
Metformin Combined With Chemotherapy and/or Immunotherapy in Solid Malignancies
Barbara Ann Karmanos Cancer Institute
Phase 1 Recruiting
NCT04742751 2025-10-31
An Open-Label Pilot Intervention Trial to Prevent Diabetes in Prediabetic Adult Survivors of Childhood Cancer
St. Jude Children's Research Hospital
Phase 2 Active not recruiting
NCT03889795 2025-10-20
Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors
University of Toledo
Phase 1 Active not recruiting
NCT02186847 2025-10-09
Chemotherapy and Radiation Therapy With or Without Metformin Hydrochloride in Treating Patients With Stage III Non-small Cell Lung Cancer
NRG Oncology
Phase 2 Completed
NCT04931017 2025-10-07
Metformin for Chemoprevention of Lung Cancer in Overweight or Obese Individuals at High Risk for Lung Cancer
Northwestern University
Phase 2 Active not recruiting
NCT06479434 2025-10-07
Serum Biomarker Levels Improvement in Poly Cystic Ovarian Syndrome: Impact of Metformin Compared to Healthy Controls
Aga Khan University
Phase NA Completed
NCT05036226 2025-10-06
COAST
Medical University of South Carolina
Phase 1/2 Recruiting
NCT02755844 2025-10-02
ENDOLA
Hospices Civils de Lyon
Phase 1/2 Completed
NCT05237960 2025-09-29
Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia
University of Arizona
Phase 2 Active not recruiting
NCT05680805 2025-09-19
Metabolic Responses of Metformin and Genetic Polymorphisms of SLC22A1 Gene in PCOS
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Phase 4 Active not recruiting
NCT01750567 2025-09-09
A Pilot Study of Metformin Therapy in Patients With Relapsed Chronic Lymphocytic Leukemia (CLL) and Untreated CLL
University of Michigan Rogel Cancer Center
Phase 2 Completed
NCT06728982 2025-08-01
Impact Of Metformin In Rectal Cancer Patients
Minia University
Phase 2/3 Completed
NCT04300790 2025-07-29
METALLICA
MedSIR
Phase 2 Completed
NCT05929495 2025-07-25
Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma
University of Milano Bicocca
Phase 2 Recruiting
NCT02040376 2025-07-16
Metformin for Brain Repair in Children With Cranial-Spinal Radiation for Medulloblastoma
The Hospital for Sick Children
Phase 3 Completed
NCT06687876 2025-07-10
MEMENTO
Amsterdam UMC, location VUmc
Phase 2 Recruiting
NCT02500147 2025-07-02
Metformin for Ectopic Fat Deposition and Metabolic Markers in Polycystic Ovary Syndrome (PCOS)
Columbia University
Phase 4 Terminated
NCT02780024 2025-06-26
Metformin, Neo-adjuvant Temozolomide and Hypo- Accelerated Radiotherapy Followed by Adjuvant TMZ in Patients With GBM
McGill University Health Centre/Research Institute of the McGill University Health Centre
Phase 2 Active not recruiting
NCT03675893 2025-06-15
RESOLVE: Abemaciclib + Letrozole +/- Metformin, Zotatifin, or Gedatolisib in Endometrial or Low-Grade Serous Ovarian Cancer
Dana-Farber Cancer Institute
Phase 2 Recruiting