A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-0587 as a Monotherapy and in Combination With Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer
Phase 1 Recruiting
136 enrolled
Drug-drug Interaction Study of Vorasidenib With Bupropion, Repaglinide, Flurbiprofen, Omeprazole, Midazolam, and Rosuvastatin in Healthy Adult Participants
Phase 1 Completed
28 enrolled
Pre-operative IRX-2 in Early Stage Breast Cancer (ESBC)
Phase 1 Completed
16 enrolled 10 charts
PEGASUS
Phase 1 Recruiting
10 enrolled
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
Phase 1 Completed
57 enrolled
Drug Interaction Study of SAR302503 in Patients With Solid Tumor
Phase 1 Completed
16 enrolled
Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors
Phase 1 Completed
56 enrolled 158 charts
A Drug-drug Interaction Study Of Fluzoparib (SHR3162) on Patients With Recurrent Ovarian Cancer
Phase 1 Completed
33 enrolled
Open-Label, Multicenter, Two-Part, Phase 1 Study to Characterize Effects of a Moderate CYP3A Inhibitor on PK of Tazemetostat, Effects of Tazemetostat on PK of CYP2C8 and CYP2C19 Substrates, and Effect of Increased Gastric pH on PK of Tazemetostat in B-cell Lymphoma or Advanced Solid Tumor Patients
Phase 1 Completed
32 enrolled 30 charts
Study to Assess the Effect of Co-Administration of AZD9833 on the Pharmacokinetics of Midazolam, of Omeprazole, of Celecoxib and of Dabigatran Etexilate in Healthy Postmenopausal Female Volunteers
Phase 1 Completed
59 enrolled
A Study to Assess the Effects of Itraconazole, Rifampicin, and Omeprazole on Pharmacokinetics of Adavosertib
Phase 1 Terminated
5 enrolled
Effect of Omeprazole on PK of Fluzoparib in Healthy Male Subjects
Phase 1 Completed
16 enrolled
Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors
Phase 1 Completed
39 enrolled
Evaluate the Effects of Patupilone on the Pharmacokinetics of Midazolam and Omeprazole in Patients With Advanced Malignancies
Phase 1 Completed
34 enrolled
BAY73-4506 Probe Substrate Study
Phase 1 Completed
41 enrolled
Effects of AZD1775 on the PK Substrates for CYP3A, CYP2C19, CYP1A2 and on QT Interval in Patients With Advanced Cancer
Phase 1 Completed
33 enrolled
Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffeine, Midazolam, and Digoxin in Cancer Subjects
Phase 1 Completed
28 enrolled
Drug-drug Interaction Study With MDV3100 and a Cocktail of Substrates
Phase 1 Completed
14 enrolled
Vandetanib
Phase 1 Completed
34 enrolled
Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced Solid Tumors
Phase 1 Completed
17 enrolled
Evaluate the Effects of Patupilone on the Pharmacokinetics of Midazolam and Omeprazole in Patients With Advanced Malignancies (Extension)
Phase 1 Withdrawn
A Study of the Effects of Multiple Doses of Dexlansoprazole, Lansoprazole, Omeprazole or Esomeprazole on the Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Participants.
Phase 1 Completed
160 enrolled 16 charts
Open-Label Study to Assess the Effect of Omeprazole on the Pharmacokinetics of VELCADE in Patients With Either Advanced Solid Tumors or Non-Hodgkin's Lymphoma.
Phase 1 Completed
20 enrolled