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NCT04804709 2025-06-08

Non-Invasive Focused Ultrasound (FUS) With Oral Panobinostat in Children With Progressive Diffuse Midline Glioma (DMG)

Phase 1 Terminated

5 enrolled 11 charts

Diffuse Intrinsic Pontine Glioma

NCT01324635 2025-05-02

Panobinostat and Stereotactic Radiation Therapy in Treating Patients With Brain Tumors

Phase 1 Terminated

Brain Neoplasms, Glioma, Meningioma

NCT04897880 2025-02-24

NORTH

Phase 2 Terminated

Brain Neoplasms, Rhabdoid Tumor

NCT04956302 2024-06-06

Panobinostat in Combination With Daratumumab, Bortezomib and Dexamethasone for the Treatment of Relapsed/Refractory Multiple Myeloma

Phase 1 Terminated

Multiple Myeloma

NCT03878524 2024-03-04

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

Phase 1 Terminated

BreastClassical hematologyGastrointestinalGenitourinaryLymphoidMyeloidOther hematologic neoplasmPlasma cell

Anemia, Blast Crisis, Breast Neoplasms, Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Neoplasm Metastasis, Pancreatic Neoplasms, Prostatic Neoplasms, Thrombocytosis, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Myelodysplastic-Myeloproliferative Diseases, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Primary Myelofibrosis

NCT04341311 2024-02-15

DIPG

Phase 1 Terminated

Diffuse Intrinsic Pontine Glioma, Neoplasms, Recurrence

NCT04326764 2023-02-16

Panobinostat Maintenance After HSCT fo High-risk AML and MDS

Phase 3 Terminated

MyeloidOther hematologic neoplasm

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT01582009 2022-08-15

Panobinostat and Everolimus in Treating Patients With Metastatic or Unresectable Renal Cell Cancer That Does Not Respond to Treatment With Sunitinib Malate or Sorafenib Tosylate

Phase 1/2 Terminated

26 enrolled 11 charts

Carcinoma, Renal Cell

NCT03256045 2022-05-09

Panobinostat, Carfilzomib, and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma

Phase 2 Terminated

9 enrolled 12 charts

Multiple Myeloma

NCT00823290 2020-12-14

Sorafenib and LBH589 in Hepatocellular Carcinoma (HCC)

Phase 1 Terminated

Gastrointestinal

Carcinoma, Hepatocellular

NCT00985946 2019-12-09

Study of Panobinostat in Patients With Neuroendocrine Tumors

Phase 2 Terminated

15 enrolled 11 charts

Neuroendocrine Tumors

NCT02518750 2019-04-03

Re-Induction Therapy for Relapsed Pediatric T-Cell Acute Lymphoblastic Leukemia or Lymphoma

Phase 2 Terminated

3 enrolled 6 charts

LymphoidOther hematologic neoplasm

Lymphoma, Non-Hodgkin, Leukemia, B-Cell, Leukemia, T-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT02676323 2018-11-14

Panobinostat With Fludarabine and Cytarabine for Treatment of Children With Acute Myeloid Leukemia or Myelodysplastic Syndrome

Phase 1 Terminated

MyeloidOther hematologic neoplasm

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute, Hematologic Neoplasms

NCT00939159 2018-08-23

Study of LBH589 for Patients With Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)

Phase 2 Terminated

17 enrolled 5 charts

Myelodysplastic Syndromes, Neoplasms

NCT01056601 2017-12-28

Panobinostat & Bortezomib in Pancreatic Cancer Progressing on Gemcitabine Therapy

Phase 2 Terminated

7 enrolled 8 charts

EndocrineGastrointestinal

Glucagonoma, Insulinoma, Pancreatic Neoplasms, Somatostatinoma

NCT00925132 2017-07-02

Treatment of Resistant Metastatic Melanoma Using Decitabine, Temozolomide and Panobinostat

Phase 1/2 Terminated

39 enrolled 8 charts

Melanoma, Neoplasm Metastasis

NCT00958022 2017-06-22

Carboplatin and Etoposide Plus LBH589 for Small Cell Lung Cancer

Phase 1 Terminated

Small Cell Lung Carcinoma

NCT01282476 2017-05-09

Panobinostat With Rituximab for Relapsed/Refractory Diffuse Large B Cell Lymphoma

Phase 2 Terminated

18 enrolled 20 charts

LymphoidSarcoma

Lymphoma, Lymphoma, Large B-Cell, Diffuse, Dendritic Cell Sarcoma, Interdigitating

NCT01032148 2017-01-12

Study of LBH589, A Deacetylase Inhibitor in Patients With Recurrent or Refractory Hodgkin or Non-Hodgkin's Lymphoma

Phase 1 Terminated

Hodgkin Disease, Lymphoma, Non-Hodgkin, Recurrence

NCT00978432 2016-11-25

Epigenetic Modulation in Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

Phase 2 Terminated

50 enrolled 11 charts

Recurrence, Lymphoma, Large B-Cell, Diffuse

NCT00777335 2015-11-24

Study of Panobinostat Monotherapy in Women With v-ERB-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (HER2) Positive Locally Recurrent or Metastatic Breast Cancer

Phase 2 Terminated

4 enrolled 11 charts

Breast Neoplasms

NCT00907179 2015-07-22

Pemetrexed and LBH589 in Patients With Advanced Non-Small Cell Lung Cancer

Phase 1 Terminated

Carcinoma, Non-Small-Cell Lung

NCT00891033 2015-02-23

Panobinostat/Velcade in Multiple Myeloma

Phase 1 Terminated

Multiple Myeloma, Neoplasms

NCT01194908 2015-01-26

Re-expression of ER in Triple Negative Breast Cancers

Phase 1/2 Terminated

5 enrolled 5 charts

Breast Neoplasms

NCT00723203 2014-09-09

Panobinostat in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia

Phase 2 Terminated

16 enrolled 4 charts

LymphoidOther hematologic neoplasm

Leukemia, Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT01090973 2013-12-16

Oral LBH589 in Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL)

Phase 2 Terminated

1 enrolled 6 charts

LymphoidOther hematologic neoplasm

Lymphoma, Non-Hodgkin, Recurrence, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Mantle-Cell

NCT00550199 2013-08-19

LBH589 and Gemcitabine in the Treatment of Solid Tumors

Phase 1 Terminated

Other solid neoplasm

Solid Tumors

NCT01528501 2013-05-01

HDAC

Phase 2 Terminated

Gastrointestinal

Stomach Neoplasms

NCT00873002 2012-03-20

Panobinostat and Sorafenib in Treating Patients With Liver Cancer That is Metastatic and/or Cannot Be Removed by Surgery

Phase 1 Terminated

Gastrointestinal

Carcinoma, Hepatocellular, Liver Neoplasms

NCT00848523 2010-07-16

Study of LBH589 (Panobinostat) to Treat Malignant Brain Tumors

Phase 2 Terminated

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma