Clinical Trials Browser

OTHER × Interventional × Protons × Clear all

NCT04190446 2026-03-16

A Study to Evaluate Hypofractionated Proton Therapy or IMRT for Recurrent, Oligometastatic Prostate Cancer

Phase 2 Active not recruiting

Prostatic Neoplasms

NCT04946357 2026-03-10

EXTREM ION

Phase NA Recruiting

Sarcoma

NCT01629498 2026-03-09

Image-Guided, Intensity-Modulated Photon or Proton Beam Radiation Therapy in Treating Patients With Stage II-IIIB Non-small Cell Lung Cancer

Phase 1/2 Active not recruiting

Carcinoma, Non-Small-Cell Lung

NCT04083937 2026-03-09

PAROS

Phase NA Recruiting

Prostatic Neoplasms

NCT01893307 2026-02-24

Intensity-Modulated Proton Beam Therapy or Intensity-Modulated Photon Therapy in Treating Patients With Stage III-IVB Oropharyngeal Cancer

Phase 3 Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT04278118 2026-02-17

HiPPI

Phase NA Recruiting

Brain Neoplasms, Meningioma, Neurilemmoma, Pituitary Neoplasms, Nerve Sheath Neoplasms

NCT04443413 2026-01-16

Phase III Study of 5tx vs 15tx of RT (X-rays or Protons) Including RNI in Breast Cancer Patients

Phase 3 Active not recruiting

Anatomic Stage I Breast Cancer AJCC v8

NCT02179086 2026-01-14

Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Phase 2 Active not recruiting

Glioblastoma

NCT03180268 2026-01-14

Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery

Phase 3 Recruiting

Meningioma

NCT03801876 2026-01-14

Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer

Phase 3 Recruiting

Gastrointestinal

Clinical Stage I Esophageal Adenocarcinoma AJCC v8

NCT01950351 2025-12-22

Hypofractionated Proton Beam Therapy for Localized Prostate Cancer

Phase 1/2 Active not recruiting

Stage I Prostate Adenocarcinoma AJCC v7

NCT01245712 2025-12-17

Radiation Therapy in Treating Patients With Stage 0-II Breast Cancer

Phase 2 Active not recruiting

Breast Carcinoma In Situ, Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating

NCT02314364 2025-12-16

A Trial of Integrating SBRT With Targeted Therapy in Stage IV Oncogene-driven NSCLC

Phase 2 Completed

27 enrolled 9 charts

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT03132532 2025-11-25

Platinum Doublet Chemotherapy and Proton Beam Radiation Therapy in Treating Patients With Stage II-III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

Phase 2 Completed

20 enrolled 20 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT04656041 2025-11-14

Folfox+Irinotecan+Chemort In Esophageal Cancer

Phase 2 Recruiting

Gastrointestinal

Gastroesophageal Junction Adenocarcinoma

NCT06008730 2025-11-10

Proton Beam Radiation Therapy After Treatment for Resected N2 Non-Small Cell Lung Cancer

Phase 2 Recruiting

Resectable Lung Non-Small Cell Carcinoma

NCT02603341 2025-11-06

Pragmatic Randomized Trial of Proton vs. Photon Therapy for Patients With Non-Metastatic Breast Cancer: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial

Phase NA Active not recruiting

Breast Neoplasms

NCT02444741 2025-10-09

Pembrolizumab and Stereotactic Body Radiation Therapy or Non-Stereotactic Wide-Field Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer

Phase 1/2 Active not recruiting

Carcinoma, Non-Small-Cell Lung

NCT04342429 2025-07-15

Prospective Study of Intensity-Modulated Proton Therapy (IMPT) for Small Cell Lung Cancer

Phase NA Recruiting

Small Cell Lung Carcinoma

NCT03180502 2025-07-11

Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

Phase 2 Active not recruiting

Astrocytoma, Glioma, Oligodendroglioma

NCT03778294 2025-07-03

18F-DOPA-PET/MRI Scan in Imaging Elderly Patients With Newly Diagnosed Grade IV Malignant Glioma or Glioblastoma During Planning for a Short Course of Proton Beam Radiation Therapy

Phase 2 Completed

43 enrolled 19 charts

Glioblastoma, Glioma

NCT01600040 2024-10-29

Proton Beam Teletherapy for Post-Hysterectomy Cancers of the Uterus and Cervix

Phase NA Completed

22 enrolled 6 charts

Uterine Cervical Neoplasms, Neoplasm Metastasis, Uterine Neoplasms

NCT05159193 2024-02-02

Neoadjuvant Treatment Pegylated Liposomal Doxorubicin Plus Cyclophosphamide Sequential Docetaxel Plus Trastuzumab and Pertuzumab Versus Docetaxel Plus Carboplatin Combined With Trastuzumab and Pertuzumab in HER-2 Positive Breast Cancer

Phase 3 Recruiting

Breast Neoplasms

NCT01811394 2023-12-06

ISAC

Phase 2 Unknown

Chordoma

NCT00614172 2023-09-21

Proton Therapy for Early Stage Breast Cancer

Phase NA Completed

50 enrolled 12 charts

Breast Neoplasms

NCT01586767 2023-09-21

Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy

Phase NA Unknown

CNSDermatologic

Sinonasal undifferentiated carcinoma, Carcinoma, Squamous Cell, Carcinoma, Adenoid Cystic, Fistula, Melanoma, Carcinoma, Mucoepidermoid, Esthesioneuroblastoma, Olfactory

NCT00831623 2023-03-13

Study of Hypofractionated Proton Beam Radiation Therapy for Prostate Cancer

Phase NA Completed

167 enrolled 6 charts

Prostatic Neoplasms

NCT02766686 2023-02-08

ProtoChoice-P

Phase NA Unknown

Prostatic Neoplasms

NCT05692661 2023-01-20

A Dose Escalation Study of Proton and Carbon Ion Irradiation for HER2 Positive and Triple Negative Breast Cancer

Phase 1 Unknown

Breast Neoplasms, Triple Negative Breast Neoplasms

NCT05548504 2022-09-21

HERAN2

Phase 2 Not yet recruiting

Frailty, Carcinoma, Non-Small-Cell Lung, Radiation Injuries

NCT05212857 2022-03-16

Enhanced Systemic Combined With Local Treatment for Primary and Metastatic Lesions in Oligo-metastatic Prostate Cancer

Phase 2 Unknown

Prostatic Neoplasms

NCT05189067 2022-01-12

Efficacy and Safety of Adjuvant Docetaxel and Trastuzumab in Stage I HER2-positive Breast Cancer

Phase 2/3 Unknown

HER2-positive Breast Cancer

NCT05141825 2021-12-02

Proton and Carbon Ion Radiotherapy for Cervical Cancer

Phase NA Completed

Uterine Cervical Neoplasms

NCT05106699 2021-11-04

Carbon Ion Followed by Proton Radiotherapy for Prostate Cancer With Pelvic Lymph Nodes Metastases

Phase NA Recruiting

Prostatic Neoplasms

NCT00592501 2021-10-26

Proton Radiotherapy With Chemotherapy for Nasopharyngeal Carcinoma

Phase 2 Completed

25 enrolled 16 charts

Nasopharyngeal Carcinoma

NCT01494155 2021-02-02

Short Course Radiation Therapy With Proton or Photon Beam Capecitabine and Hydroxychloroquine for Resectable Pancreatic Cancer

Phase 2 Unknown

Gastrointestinal

Pancreatic Neoplasms

NCT03949933 2020-03-05

Proton and Carbon Ion Radiotherapy for Locally Advanced Pancreatic Cancer

Phase NA Completed

Gastrointestinal

Pancreatic Neoplasms

NCT02345772 2018-02-20

Neohttp

Phase 1/2 Terminated

4 enrolled 1 chart

HER2-positive Breast Cancer

NCT03006614 2017-01-16

PERS

Phase 3 Unknown

Breast Neoplasms

NCT02070393 2015-02-04

Breast Sparing

Phase EARLY_PHASE1 Terminated

Hodgkin Disease

NCT00614484 2014-05-22

Chemotherapy and Proton Radiation for the Treatment of Locally Advanced Lung Cancer

Phase 1/2 Terminated

28 enrolled 8 charts

Locally Advanced Non-Small Cell Lung Cancer

NCT00614913 2012-08-20

Proton Beam Therapy for Treatment of Hepatocellular Carcinoma

Phase 1/2 Completed

76 enrolled 8 charts

Gastrointestinal

Carcinoma, Hepatocellular, Liver Neoplasms

NCT01182779 2010-08-17

HIT-1

Phase 3 Unknown

Chordoma, Neoplasms