Clinical Trials Browser

Interventional × Protons × Clear all

NCT04671667 2026-03-18

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Phase 2 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT04190446 2026-03-16

A Study to Evaluate Hypofractionated Proton Therapy or IMRT for Recurrent, Oligometastatic Prostate Cancer

Phase 2 Active not recruiting

Prostatic Neoplasms

NCT04946357 2026-03-10

EXTREM ION

Phase NA Recruiting

Sarcoma

NCT01629498 2026-03-09

Image-Guided, Intensity-Modulated Photon or Proton Beam Radiation Therapy in Treating Patients With Stage II-IIIB Non-small Cell Lung Cancer

Phase 1/2 Active not recruiting

Carcinoma, Non-Small-Cell Lung

NCT04083937 2026-03-09

PAROS

Phase NA Recruiting

Prostatic Neoplasms

NCT01893307 2026-02-24

Intensity-Modulated Proton Beam Therapy or Intensity-Modulated Photon Therapy in Treating Patients With Stage III-IVB Oropharyngeal Cancer

Phase 3 Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT04278118 2026-02-17

HiPPI

Phase NA Recruiting

Brain Neoplasms, Meningioma, Neurilemmoma, Pituitary Neoplasms, Nerve Sheath Neoplasms

NCT04443413 2026-01-16

Phase III Study of 5tx vs 15tx of RT (X-rays or Protons) Including RNI in Breast Cancer Patients

Phase 3 Active not recruiting

Anatomic Stage I Breast Cancer AJCC v8

NCT02179086 2026-01-14

Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Phase 2 Active not recruiting

Glioblastoma

NCT03180268 2026-01-14

Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery

Phase 3 Recruiting

Meningioma

NCT03801876 2026-01-14

Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer

Phase 3 Recruiting

Gastrointestinal

Clinical Stage I Esophageal Adenocarcinoma AJCC v8

NCT01950351 2025-12-22

Hypofractionated Proton Beam Therapy for Localized Prostate Cancer

Phase 1/2 Active not recruiting

Stage I Prostate Adenocarcinoma AJCC v7

NCT01245712 2025-12-17

Radiation Therapy in Treating Patients With Stage 0-II Breast Cancer

Phase 2 Active not recruiting

Breast Carcinoma In Situ, Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating

NCT02314364 2025-12-16

A Trial of Integrating SBRT With Targeted Therapy in Stage IV Oncogene-driven NSCLC

Phase 2 Completed

27 enrolled 9 charts

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT03132532 2025-11-25

Platinum Doublet Chemotherapy and Proton Beam Radiation Therapy in Treating Patients With Stage II-III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

Phase 2 Completed

20 enrolled 20 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT04656041 2025-11-14

Folfox+Irinotecan+Chemort In Esophageal Cancer

Phase 2 Recruiting

Gastrointestinal

Gastroesophageal Junction Adenocarcinoma

NCT06008730 2025-11-10

Proton Beam Radiation Therapy After Treatment for Resected N2 Non-Small Cell Lung Cancer

Phase 2 Recruiting

Resectable Lung Non-Small Cell Carcinoma

NCT02603341 2025-11-06

Pragmatic Randomized Trial of Proton vs. Photon Therapy for Patients With Non-Metastatic Breast Cancer: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial

Phase NA Active not recruiting

Breast Neoplasms

NCT02444741 2025-10-09

Pembrolizumab and Stereotactic Body Radiation Therapy or Non-Stereotactic Wide-Field Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer

Phase 1/2 Active not recruiting

Carcinoma, Non-Small-Cell Lung

NCT04342429 2025-07-15

Prospective Study of Intensity-Modulated Proton Therapy (IMPT) for Small Cell Lung Cancer

Phase NA Recruiting

Small Cell Lung Carcinoma

NCT03180502 2025-07-11

Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

Phase 2 Active not recruiting

Astrocytoma, Glioma, Oligodendroglioma

NCT03778294 2025-07-03

18F-DOPA-PET/MRI Scan in Imaging Elderly Patients With Newly Diagnosed Grade IV Malignant Glioma or Glioblastoma During Planning for a Short Course of Proton Beam Radiation Therapy

Phase 2 Completed

43 enrolled 19 charts

Glioblastoma, Glioma

NCT04894643 2025-05-08

PARC

Phase NA Recruiting

Gastrointestinal

Pancreatic Neoplasms

NCT01993810 2024-12-18

Comparing Photon Therapy To Proton Therapy To Treat Patients With Lung Cancer

Phase 3 Active not recruiting

Carcinoma, Non-Small-Cell Lung

NCT01600040 2024-10-29

Proton Beam Teletherapy for Post-Hysterectomy Cancers of the Uterus and Cervix

Phase NA Completed

22 enrolled 6 charts

Uterine Cervical Neoplasms, Neoplasm Metastasis, Uterine Neoplasms

NCT05159193 2024-02-02

Neoadjuvant Treatment Pegylated Liposomal Doxorubicin Plus Cyclophosphamide Sequential Docetaxel Plus Trastuzumab and Pertuzumab Versus Docetaxel Plus Carboplatin Combined With Trastuzumab and Pertuzumab in HER-2 Positive Breast Cancer

Phase 3 Recruiting

Breast Neoplasms

NCT01811394 2023-12-06

ISAC

Phase 2 Unknown

Chordoma

NCT00614172 2023-09-21

Proton Therapy for Early Stage Breast Cancer

Phase NA Completed

50 enrolled 12 charts

Breast Neoplasms

NCT01586767 2023-09-21

Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy

Phase NA Unknown

CNSDermatologic

Sinonasal undifferentiated carcinoma, Carcinoma, Squamous Cell, Carcinoma, Adenoid Cystic, Fistula, Melanoma, Carcinoma, Mucoepidermoid, Esthesioneuroblastoma, Olfactory

NCT00831623 2023-03-13

Study of Hypofractionated Proton Beam Radiation Therapy for Prostate Cancer

Phase NA Completed

167 enrolled 6 charts

Prostatic Neoplasms

NCT02766686 2023-02-08

ProtoChoice-P

Phase NA Unknown

Prostatic Neoplasms

NCT05692661 2023-01-20

A Dose Escalation Study of Proton and Carbon Ion Irradiation for HER2 Positive and Triple Negative Breast Cancer

Phase 1 Unknown

Breast Neoplasms, Triple Negative Breast Neoplasms

NCT05548504 2022-09-21

HERAN2

Phase 2 Not yet recruiting

Frailty, Carcinoma, Non-Small-Cell Lung, Radiation Injuries

NCT05212857 2022-03-16

Enhanced Systemic Combined With Local Treatment for Primary and Metastatic Lesions in Oligo-metastatic Prostate Cancer

Phase 2 Unknown

Prostatic Neoplasms

NCT05189067 2022-01-12

Efficacy and Safety of Adjuvant Docetaxel and Trastuzumab in Stage I HER2-positive Breast Cancer

Phase 2/3 Unknown

HER2-positive Breast Cancer

NCT05141825 2021-12-02

Proton and Carbon Ion Radiotherapy for Cervical Cancer

Phase NA Completed

Uterine Cervical Neoplasms

NCT05106699 2021-11-04

Carbon Ion Followed by Proton Radiotherapy for Prostate Cancer With Pelvic Lymph Nodes Metastases

Phase NA Recruiting

Prostatic Neoplasms

NCT00592501 2021-10-26

Proton Radiotherapy With Chemotherapy for Nasopharyngeal Carcinoma

Phase 2 Completed

25 enrolled 16 charts

Nasopharyngeal Carcinoma

NCT01494155 2021-02-02

Short Course Radiation Therapy With Proton or Photon Beam Capecitabine and Hydroxychloroquine for Resectable Pancreatic Cancer

Phase 2 Unknown

Gastrointestinal

Pancreatic Neoplasms

NCT03949933 2020-03-05

Proton and Carbon Ion Radiotherapy for Locally Advanced Pancreatic Cancer

Phase NA Completed

Gastrointestinal

Pancreatic Neoplasms

NCT02345772 2018-02-20

Neohttp

Phase 1/2 Terminated

4 enrolled 1 chart

HER2-positive Breast Cancer

NCT03006614 2017-01-16

PERS

Phase 3 Unknown

Breast Neoplasms

NCT02070393 2015-02-04

Breast Sparing

Phase EARLY_PHASE1 Terminated

Hodgkin Disease

NCT00614484 2014-05-22

Chemotherapy and Proton Radiation for the Treatment of Locally Advanced Lung Cancer

Phase 1/2 Terminated

28 enrolled 8 charts

Locally Advanced Non-Small Cell Lung Cancer

NCT00614913 2012-08-20

Proton Beam Therapy for Treatment of Hepatocellular Carcinoma

Phase 1/2 Completed

76 enrolled 8 charts

Gastrointestinal

Carcinoma, Hepatocellular, Liver Neoplasms

NCT01182779 2010-08-17

HIT-1

Phase 3 Unknown

Chordoma, Neoplasms