Clinical Trials

33 enrolled 6 charts

Lymphangioleiomyomatosis

NCT01625351 2026-02-06

A Study of CD45RA+ Depleted Haploidentical Stem Cell Transplantation in Children With Relapsed or Refractory Solid Tumors and Lymphomas

CNSDermatologicGastrointestinalGenitourinaryLymphoidSarcoma

23 enrolled

Carcinoma, Renal Cell, Digestive System Neoplasms, Carcinoma, Hepatocellular, Lymphoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Adenocarcinoma, Clear Cell, Rhabdoid Tumor

NCT00975819 2026-01-06

Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies

61 enrolled 7 charts

Classical hematology

Tufted angioma, Lymphangioma, Thrombocytopenia

NCT01282697 2025-12-22

RAPIRI

42 enrolled

Other solid neoplasm

Refractory Solid Tumors in Children

NCT01869114 2025-12-10

Sirolimus and Azacitidine in Treating Patients With High Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia That is Recurrent or Not Eligible for Intensive Chemotherapy

Other hematologic neoplasm

57 enrolled 13 charts

Chromosome 5q Deletion Syndrome, Congenital Abnormalities, Leukemia, Myeloid, Acute

NCT02793544 2025-08-06

HLA-Mismatched Unrelated Donor Bone Marrow Transplantation With Post-Transplantation Cyclophosphamide

80 enrolled 56 charts

Myelodysplastic Syndromes, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Biphenotypic, Acute, Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT04473911 2025-07-20

Haplo Peripheral Blood Sct In GVHD Prevention

25 enrolled

Graft vs Host Disease, Hodgkin Disease, Lymphoma, Non-Hodgkin, Myelodysplastic Syndromes, Myeloproliferative Disorders, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT02722668 2025-07-04

UCB Transplant for Hematological Diseases Using a Non Myeloablative Prep

LymphoidMyeloidOther hematologic neoplasmPlasma cellSarcoma

15 enrolled 15 charts

Bone Marrow Failure Disorders, Burkitt Lymphoma, Hodgkin Disease, Leukemia, Leukemia, Plasma Cell, Lymphoma, Follicular, Multiple Myeloma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Prolymphocytic, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Lymphoma, T-Cell, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Dendritic Cell Sarcoma, Interdigitating, Primary Myelofibrosis

NCT04094675 2025-06-10

Sirolimus for Cowden Syndrome With Colon Polyposis

5 enrolled

Hamartoma Syndrome, Multiple

NCT02517918 2025-06-08

METZOLIMOS

Phase EARLY_PHASE1 Completed

23 enrolled 15 charts

Sarcoma

Osteosarcoma

NCT02711202 2025-06-04

Sequential Targeting of Cluster of Differentiation 52 (CD52) and Tumor Necrosis Factor (TNF) Allows Early Minimization Therapy in Kidney Transplantation

Phase NA Completed

20 enrolled 11 charts

Genitourinary

Kidney Transplantation

NCT01184885 2025-05-04

A Pilot Study to Determine the Safety and Tolerability of Sirolimus Given With Hyper-CVAD Chemotherapy

7 enrolled 8 charts

Phase EARLY_PHASE1 Completed

Burkitt Lymphoma, Recurrence, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

NCT01822015 2025-04-29

Sirolimus, Idarubicin, and Cytarabine in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

55 enrolled

Other hematologic neoplasm

Congenital Abnormalities, Leukemia, Erythroblastic, Acute, Leukemia, Megakaryoblastic, Acute, Leukemia, Monocytic, Acute, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Acute

NCT04339062 2025-04-23

CONTRAC

12 enrolled 13 charts

Dermatologic

Cutaneous Squamous Cell Carcinoma

NCT02420613 2025-04-02

Vorinostat and Temsirolimus With or Without Radiation Therapy in Treating Younger Patients With Newly Diagnosed or Progressive Diffuse Intrinsic Pontine Glioma

18 enrolled

CNS

Diffuse Intrinsic Pontine Glioma

NCT03095703 2024-10-24

Sirolimus and Familial Adenomatous Polyposis (FAP)

4 enrolled 10 charts

Gastrointestinal

Adenomatous Polyposis Coli

NCT04595513 2024-05-16

STOP2

5 enrolled 15 charts

Epilepsy, Tuberous Sclerosis

NCT00235560 2024-02-29

LAM-RAPA

Other hematologic neoplasm

50 enrolled

Leukemia, Myeloid, Acute

NCT03433183 2023-12-26

SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors

21 enrolled

CNSSarcoma

Neurofibromatosis 1, Neurofibrosarcoma

NCT00414648 2023-11-02

MILES

Phase 3 Completed

89 enrolled 15 charts

Lymphangioleiomyomatosis

NCT04448873 2023-09-26

Guided Discontinuation Versus Maintenance Treatment of Sirolimus in Pediatric Patients With Kaposiform Hemangioendothelioma

Phase 4 Completed

30 enrolled

Kaposiform Hemangioendothelioma, Kasabach-Merritt Syndrome

NCT03826628 2023-09-08

Dose-Ranging Efficacy and Safety Study of Topical Rapamycin Cream for Facial Angiofibroma Associated With Tuberous Sclerosis Complex

Phase 2/3 Completed

107 enrolled 24 charts

Tuberous Sclerosis

NCT01027000 2023-05-06

Donor Stem Cell Transplant in Treating Patients With High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

68 enrolled 8 charts

Leukemia, Lymphoma, Leukemia, Lymphocytic, Chronic, B-Cell

NCT03253913 2023-02-01

RESULT

25 enrolled 11 charts

Lymphangioleiomyomatosis

NCT04077515 2023-01-30

Safety and Efficacy of Low-dose Sirolimus to Kaposiform Hemangioendothelioma

Phase 4 Completed

92 enrolled

Kaposiform Hemangioendothelioma, Hemangioma, Kasabach-Merritt Syndrome

NCT00406393 2023-01-04

BMT CTN 0402

Phase 3 Completed

304 enrolled 20 charts

Myelodysplastic Syndromes, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT01767194 2022-10-24

Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma

73 enrolled 12 charts

CNS

Neuroblastoma, Ganglioneuroblastoma

NCT02688881 2022-06-15

Study to Evaluate the Safety and Efficacy of Sirolimus, in Subject With Refractory Solid Tumors

Phase 4 Completed

6 enrolled

Other solid neoplasm

Refractory Solid Tumors

NCT03188068 2022-04-21

Sirolimus Versus Sirolimus Plus Prednisolone for Kaposiform Hemangioendothelioma

30 enrolled

Kaposiform Hemangioendothelioma, Kasabach-Merritt Syndrome

NCT02821507 2022-04-20

Sirolimus and Cyclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and Chondrosarcoma

70 enrolled

Sarcoma

Liposarcoma, Myxoid, Chondrosarcoma, Mesenchymal

NCT02756572 2021-11-08

Early Allogeneic Hematopoietic Cell Transplantation in Treating Patients With Relapsed or Refractory High-Grade Myeloid Neoplasms

MyeloidOther hematologic neoplasm

30 enrolled 28 charts

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT03047980 2021-11-01

Trial of Sirolimus for Cognitive Impairment in Sturge-Weber Syndrome

Phase 2/3 Completed

10 enrolled 11 charts

Sturge-Weber Syndrome, Cognitive Dysfunction

NCT01381692 2021-10-04

Bortezomib, Rituximab, and Dexamethasone With or Without Temsirolimus in Treating Patients With Untreated or Relapsed Waldenstrom Macroglobulinemia or Relapsed or Refractory Mantle Cell or Follicular Lymphoma

9 enrolled 8 charts

Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell

NCT00350181 2021-09-23

Sirolimus & Mycophenolate Mofetil as GVHD Prophylaxis in Myeloablative, Matched Related Donor HCT

11 enrolled

Hematologic Diseases, Leukemia, Lymphoma, Non-Hodgkin

NCT03018223 2021-09-16

Calcineurin Inhibitor-Free GVHD Prevention Regimen After Related Haplo PBSCT

LymphoidMyeloidOther hematologic neoplasmPlasma cell

32 enrolled 12 charts

Graft vs Host Disease, Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myelodysplastic Syndromes, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myelomonocytic, Chronic, Primary Myelofibrosis

NCT02596828 2021-08-05

Prospective Pilot Trial to Assess a Multimodal Molecular Targeted Therapy in Children, Adolescent and Young Adults With Relapsed or Refractory High-grade Pineoblastoma

4 enrolled

Pinealoma

NCT02048384 2021-04-12

A Study of Metformin With or Without Rapamycin as Maintenance Therapy After Induction Chemotherapy in Subjects With Pancreatic Cancer

22 enrolled

Gastrointestinal

Adenocarcinoma, Neoplasm Metastasis, Pancreatic Neoplasms

NCT01929642 2021-03-29

RAPT

Phase EARLY_PHASE1 Completed

3 enrolled 10 charts

Autistic Disorder, Tuberous Sclerosis, Self-Injurious Behavior

NCT02753309 2021-03-19

A Study of Rapamycin Combined With Intravesical BCG in Patients With Non-muscle Invasive Bladder Cancer

33 enrolled

Genitourinary

Urinary Bladder Neoplasms

NCT01266057 2021-03-04

Sirolimus or Vorinostat and Hydroxychloroquine in Advanced Cancer

143 enrolled

Tumor-Agnostic

Neoplasms

NCT02423915 2021-01-08

Fucosylated T Cells for Graft Versus Host Disease (GVHD) Prevention

5 enrolled

Graft vs Host Disease, Leukemia, Lymphoma

NCT00305682 2020-11-19

Non-Myeloablative Conditioning for Unrelated Donor Umbilical Cord Blood Transplant

295 enrolled 27 charts

Leukemia, Lymphoma, Myelodysplastic Syndromes, Myeloproliferative Disorders

NCT01526356 2020-10-26

Treatment

179 enrolled 13 charts

Tuberous Sclerosis, Angiofibroma

NCT01467986 2020-10-06

RIST-rNB-2011

130 enrolled

CNS

Neuroblastoma

NCT02061397 2020-08-25

SOS

10 enrolled 6 charts

Tuberous Sclerosis, Lymphangioleiomyomatosis

NCT00047073 2020-08-03

Sirolimus in Treating Patients With Glioblastoma Multiforme

13 enrolled

CNSSarcoma

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00509431 2020-07-31

Erlotinib and Sirolimus in Treating Patients With Recurrent Malignant Glioma

19 enrolled

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT01331135 2020-05-29

Aflac ST0901

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

18 enrolled

Astrocytoma, Carcinoma, Renal Cell, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Recurrence, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Rhabdoid Tumor

NCT01536054 2020-03-27

Sirolimus and Vaccine Therapy in Treating Patients With Stage II-IV Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Cancer