Clinical Trials

Phase 1 Active not recruiting

Small Cell Lung Carcinoma

NCT05353439 2026-03-18

Testing of Tazemetostat in Combination With Topotecan and Pembrolizumab in Patients With Recurrent Small Cell Lung Cancer

18 enrolled

Phase 1/2 Not yet recruiting

Small Cell Lung Carcinoma

NCT07437963 2026-03-18

Testing the Addition of Iberdomide to Therapy in People With Neuroblastoma That Has Come Back, Not Responded to Treatment, or Gotten Worse

76 enrolled

Phase 2/3 Active not recruiting

Neuroblastoma, Ganglioneuroblastoma

NCT02502266 2026-03-05

Testing the Combination of Cediranib and Olaparib in Comparison to Each Drug Alone or Other Chemotherapy in Recurrent Platinum-Resistant Ovarian Cancer

582 enrolled 21 charts

Phase 2 Active not recruiting

Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT03786783 2025-10-09

Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma

42 enrolled 12 charts

Phase 1/2 Active not recruiting

Ganglioneuroblastoma

NCT01012817 2025-09-15

Veliparib and Topotecan Hydrochloride in Treating Patients With Solid Tumors, Relapsed or Refractory Ovarian Cancer, or Primary Peritoneal Cancer

88 enrolled 23 charts

Fallopian Tube Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms

NCT01931098 2025-08-11

Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab

35 enrolled 13 charts

CNSSarcoma

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT02487095 2025-04-13

Trial of Topotecan With VX-970 (M6620), an ATR Kinase Inhibitor, in Small Cell Cancers and Extrapulmonary Small Cell Cancers

EndocrineGynecologicThoracic

62 enrolled 29 charts

Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Ovarian Neoplasms, Carcinoma, Neuroendocrine, Small Cell Lung Carcinoma

NCT04514497 2025-03-06

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer

Phase 1 Active not recruiting

28 enrolled

EndocrineGastrointestinalThoracic

Lung Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Carcinoma, Neuroendocrine, Small Cell Lung Carcinoma

NCT05295589 2023-09-26

Comparing Standard of Care Chemotherapy Treatment to the Combination of Copanlisib and Olaparib for Recurrent Platinum Resistant Ovarian Cancer That Has Progressed Through PARP Inhibitor Therapy

Phase 2 Withdrawn

Platinum-Refractory Fallopian Tube Carcinoma

NCT01266447 2019-08-08

Veliparib, Topotecan Hydrochloride, and Filgrastim or Pegfilgrastim in Treating Patients With Persistent or Recurrent Cervical Cancer

27 enrolled 11 charts

Uterine Cervical Neoplasms

NCT00098956 2018-07-23

7-hydroxystaurosporine and Topotecan Hydrochloride in Treating Patients With Relapsed or Progressed Small Cell Lung Cancer

19 enrolled 9 charts

Small Cell Lung Carcinoma

NCT00828139 2017-08-21

S0802 - Topotecan With or Without Aflibercept in Treating Patients With Extensive-Stage Small Cell Lung Cancer

189 enrolled 15 charts

Small Cell Lung Carcinoma

NCT00117013 2017-07-02

A Pilot Trial of Oral Topotecan for the Treatment of Refractory Advanced Solid Neoplasms Expressing HIF-1a

16 enrolled

Tumor-Agnostic

Neoplasm Metastasis, Neoplasms

NCT00553189 2017-07-02

Safety Study of ABT-888 Plus Topotecan Hydrochloride to Treat Patients With Solid Tumors and Lymphomas

31 enrolled

Lymphoid

Lymphoma, Neoplasms

NCT01533181 2016-01-14

Linsitinib or Topotecan Hydrochloride in Treating Patients With Relapsed Small Cell Lung Cancer

44 enrolled 10 charts

Small Cell Lung Carcinoma

NCT00313612 2015-11-27

Oxaliplatin and Topotecan in Advance Ovarian Cancer

Phase 2 Terminated

39 enrolled 7 charts

Carcinoma, Ovarian Epithelial

NCT00634244 2015-07-07

Comparing Three Different Combination Chemotherapy Regimens in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Other hematologic neoplasm

92 enrolled 10 charts

Congenital Abnormalities, Leukemia, Erythroblastic, Acute, Leukemia, Megakaryoblastic, Acute, Leukemia, Monocytic, Acute, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Acute

NCT00521144 2015-05-05

Obatoclax Mesylate and Topotecan Hydrochloride in Treating Patients With Relapsed or Refractory Small Cell Lung Cancer or Advanced Solid Tumors

22 enrolled 9 charts

Small Cell Lung Carcinoma

NCT00516295 2014-09-02

Vincristine Sulfate, Topotecan Hydrochloride, and Cyclophosphamide With or Without Bevacizumab in Treating Young Patients With Refractory or First Recurrent Extracranial Ewing Sarcoma

7 enrolled 6 charts

Neuroectodermal Tumors, Primitive, Peripheral

NCT00003064 2014-01-06

Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Persistent Epithelial Ovarian Cancer, Fallopian Tube, or Primary Peritoneal Cancer

Phase 1/2 Unknown

30 enrolled

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT00003065 2014-01-06

Topotecan and Paclitaxel in Treating Patients With Recurrent or Metastatic Cancer of the Cervix

25 enrolled

Uterine Cervical Neoplasms

NCT00004979 2014-01-06

Topotecan and Paclitaxel in Treating Patients With Advanced Non-small Cell Lung Cancer or Other Advanced Solid Tumors

Classical hematologyMyeloidOther hematologic neoplasm

Other solid neoplasm

Unspecified Adult Solid Tumor, Protocol Specific

NCT00003827 2013-12-04

Combination Chemotherapy in Treating Patients With Myelodysplastic Syndrome

Phase 2 Unknown

25 enrolled

Anemia, Refractory, with Excess of Blasts, Leukemia, Myelodysplastic Syndromes

NCT00392340 2013-09-17

Topotecan, Vincristine, and Doxorubicin in Treating Young Patients With Refractory Stage 4 Neuroblastoma

Phase 2 Unknown

63 enrolled

Neuroblastoma

NCT00003732 2013-08-12

Combination Chemotherapy in Treating Patients With Stage II, Stage III, or Stage IV Ovarian Cancer

80 enrolled

Carcinoma, Ovarian Epithelial, Ovarian Neoplasms

NCT00379457 2013-08-12

Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma

Phase 3 Unknown

600 enrolled

Sarcoma

Malignant mesenchymal tumor, Sarcoma

NCT00410631 2013-08-07

Observation, Combination Chemotherapy, Radiation Therapy, and/or Autologous Stem Cell Transplant in Treating Young Patients With Neuroblastoma

Phase 3 Unknown

642 enrolled

Neuroblastoma

NCT00014690 2013-08-02

ZD9331 With or Without Topotecan in Treating Patients With Refractory or Recurrent Epithelial Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT00389766 2013-07-10

High-Dose Iodine I 131 Metaiodobenzylguanidine, Topotecan, and Peripheral Stem Cell Transplant in Treating Young Patients With Relapsed Stage 4 Neuroblastoma or Primary Resistant High-Risk Neuroblastoma

Phase 2 Withdrawn

Neuroblastoma

NCT00003619 2013-06-26

Combination Chemotherapy Followed By Peripheral Stem Cell Transplantation or Isotretinoin in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Acute Lymphocytic Leukemia

Classical hematologyLymphoidMyeloidOther hematologic neoplasm

Anemia, Refractory, Anemia, Refractory, with Excess of Blasts, Blast Crisis, Leukemia, Myelodysplastic Syndromes, Myeloproliferative Disorders, Polycythemia Vera, Thrombocytopenia, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Primary Myelofibrosis

NCT00055614 2013-06-26

Topotecan in Treating Patients With Advanced Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer

20 enrolled

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT00002587 2013-06-03

Paclitaxel Plus Topotecan in Treating Patients With Solid Tumors

20 enrolled

Other solid neoplasm

Unspecified Adult Solid Tumor, Protocol Specific

NCT00005811 2013-02-21

Topotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous Treatment