Clinical Trials Browser

Terminated × Topotecan × Clear all

NCT05429502 2025-10-10

Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors

Phase 1 Terminated

Glioma, Medulloblastoma, Neuroblastoma, Recurrence, Rhabdomyosarcoma

NCT05870748 2025-09-23

REFRaME-O1: A Study to Investigate the Efficacy and Safety of Luveltamab Tazevibulin Versus Investigator's Choice (IC) Chemotherapy in Women With Ovarian Cancer (Including Fallopian Tube or Primary Peritoneal Cancers) Expressing FOLR1

Phase 2/3 Terminated

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT05092360 2025-08-28

ARTISTRY-7

Phase 3 Terminated

456 enrolled 19 charts

Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT04239092 2025-07-17

9-ING-41 in Pediatric Patients With Refractory Malignancies.

Phase 1 Terminated

Diffuse Intrinsic Pontine Glioma, Meningioma, Neoplasms, Neuroblastoma

NCT02569957 2025-05-04

Effect of Acetylcysteine With Topotecan Hydrochloride on the Tumor Microenvironment in Patients With Persistent or Recurrent High Grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Phase 2 Terminated

1 enrolled 5 charts

Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT04029688 2024-12-20

A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Activity of Idasanutlin in Combination With Either Chemotherapy or Venetoclax in Treatment of Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias or Solid Tumors

Phase 1/2 Terminated

38 enrolled 34 charts

CNSLymphoidOther hematologic neoplasm

Neuroblastoma, Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT01904253 2024-09-05

A Phase 2 Study Comparing TAS-102 Versus Topotecan or Amrubicin to Treat Small Cell Lung Cancer Following Platinum-Based Chemotherapy

Phase 2 Terminated

Small Cell Lung Carcinoma

NCT02649673 2023-12-05

LCL161 Plus Topotecan for Patients With Relapsed/Refractory Small Cell Lung Cancer and Select Gynecologic Malignancies

Phase 1 Terminated

GynecologicThoracic

Lung Neoplasms, Ovarian Neoplasms, Small Cell Lung Carcinoma

NCT01076400 2023-09-18

MK-1775-008

Phase 1/2 Terminated

7 enrolled 6 charts

Uterine Cervical Neoplasms

NCT03927274 2023-05-25

Intratumorally-Administered Topotecan Using Convection-Enhanced Delivery in Patients With Grade III/ IV Glioma

Phase EARLY_PHASE1 Terminated

Brain Neoplasms, Glioma

NCT02963090 2023-02-15

Pembrolizumab vs Topotecan in Patients With Small Cell Lung Cancer

Phase 2 Terminated

9 enrolled 11 charts

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00014443 2023-01-09

Topotecan and Thalidomide in Treating Patients With Recurrent or Refractory Malignant Glioma

Phase 2 Terminated

Astrocytoma, Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT04022876 2022-10-10

A Study of ALRN-6924 for the Prevention of Chemotherapy-induced Side Effects (Chemoprotection)

Phase 1 Terminated

Carcinoma, Non-Small-Cell Lung, Small Cell Lung Carcinoma

NCT01803269 2020-06-26

Topotecan Hydrochloride or Cyclodextrin-Based Polymer-Camptothecin CRLX101 in Treating Patients With Recurrent Small Cell Lung Cancer

Phase 2 Terminated

29 enrolled 14 charts

Small Cell Lung Carcinoma

NCT02500459 2019-03-01

Topotecan in Glioma Undergoing A Clinically-Indicated Surgical Resection

Phase EARLY_PHASE1 Terminated

Brain Neoplasms, Glioma, Neoplasms

NCT00315211 2018-08-20

Weekly Topotecan With Docetaxel in Recurrent Small Cell Lung Cancer

Phase 2 Terminated

Mediastinal Neoplasms

NCT00005029 2018-04-12

Topotecan in Treating Patients With Recurrent Ovarian Epithelial or Primary Peritoneal Cancer

Phase 2 Terminated

Carcinoma, Ovarian Epithelial, Ovarian Neoplasms

NCT00720096 2018-01-02

Genomic Directed Salvage Chemotherapy With Either Liposomal Doxorubicin Or Topotecan

Phase NA Terminated

4 enrolled 8 charts

Ovarian Neoplasms

NCT00158886 2017-11-14

Oral Topotecan As A Radiosensitizing Agent In Rectal Cancer

Phase 1 Terminated

Carcinoma, Renal Cell

NCT02100007 2017-10-02

ME-344 Given in Combination With Hycamtin® in Patients With Solid Tumors

Phase 1/2 Terminated

46 enrolled 17 charts

GynecologicThoracic

Neoplasm Metastasis, Ovarian Neoplasms, Recurrence, Small Cell Lung Carcinoma

NCT00808899 2017-05-30

Neuroblastoma Protocol 2008: Therapy for Children With Advanced Stage High Risk Neuroblastoma

Phase 2 Terminated

4 enrolled 5 charts

Neuroblastoma

NCT02107378 2016-11-30

Efficacy of DCVAC/OvCa Plus Standard of Care in Relapsed Platinum Resistant Epithelial Ovarian Carcinoma

Phase 2 Terminated

Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Recurrence

NCT01003938 2016-06-30

Topotecan With Erlotinib for Topotecan Pretreated Ovarian Cancer

Phase 2 Terminated

6 enrolled 7 charts

Ovarian Neoplasms

NCT00087048 2016-03-22

Topotecan in Treating Patients With Recurrent Extensive-Stage Small Cell Lung Cancer

Phase 2 Terminated

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00526799 2016-03-03

Sorafenib + Topotecan for Platinum-Resistant Recurrent Ovarian Cancer

Phase 1/2 Terminated

30 enrolled 16 charts

Ovarian Neoplasms

NCT00812266 2016-01-26

Topotecan and Cisplatin Versus Etoposide and Carboplatin in 1st Line Treatment of Patients With Small Cell Lung Cancer and Extensive Disease (SCLC-ED)

Phase 3 Terminated

Small Cell Lung Carcinoma

NCT01840943 2015-12-23

A Study to Compare CAELYX With Topotecan HCL in Patients With Recurrent Epithelial Ovarian Carcinoma Following Failure of First-Line, Platinum-Based Chemotherapy

Phase 3 Terminated

32 enrolled 13 charts

Carcinoma, Ovarian Epithelial, Carcinoma, Neoplasms, Ovarian Neoplasms

NCT00313612 2015-11-27

Oxaliplatin and Topotecan in Advance Ovarian Cancer

Phase 2 Terminated

39 enrolled 7 charts

Carcinoma, Ovarian Epithelial

NCT00437073 2015-10-15

Brain Metastases In ErbB2-Positive Breast Cancer

Phase 2 Terminated

22 enrolled 8 charts

Brain Neoplasms, Breast Neoplasms

NCT00002948 2014-07-02

High-Dose Topotecan and Peripheral Stem Cell Transplantation in Treating Patients With Refractory Cancer

Phase 1 Terminated

Other solid neoplasm

Unspecified Adult Solid Tumor, Protocol Specific

NCT00107471 2013-12-10

Topotecan, G-CSF, and Radiation Therapy in Treating Young Patients With Newly Diagnosed Brain Stem Glioma

Phase 1/2 Terminated

Brain Neoplasms, Central Nervous System Neoplasms

NCT00003156 2013-04-11

Topotecan in Treating Patients With Recurrent or Refractory Cancer of the Uterus

Phase 2 Terminated

Sarcoma

NCT00006032 2012-12-11

Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Women With Metastatic Breast Cancer

Phase 2 Terminated

Breast Neoplasms

NCT01177501 2012-11-19

ITOV04

Phase 1 Terminated

Ovarian Neoplasms, Recurrence

NCT00005612 2012-09-26

ETC

Phase 1/2 Terminated

Carcinoma, Ovarian Epithelial, Ovarian Neoplasms

NCT00112619 2011-06-30

Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors

Phase 1 Terminated

CNSLymphoidOther hematologic neoplasmSarcoma

Familial ependymoma, Astrocytoma, Burkitt Lymphoma, Leukemia, Lymphoma, Medulloblastoma, Neoplasms, Unknown Primary, Oligodendroglioma, Recurrence, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor, Optic Nerve Glioma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile, Dendritic Cell Sarcoma, Interdigitating, Meningeal Carcinomatosis

NCT00888810 2009-04-28

TOPO-LAPA

Phase 2 Terminated

Neoplasms, Recurrence

NCT00322920 2008-02-15

Efficacy Study of Weekly Topotecan With Cisplatin in Advanced Stage or Recurrent Cervical Cancer

Phase 1 Terminated

Uterine Cervical Neoplasms

NCT00194935 2006-09-13

Weekly Topotecan Therapy in Patients With Ovarian Cancer

Phase 2 Terminated

Ovarian Neoplasms