CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer
Phase 1 Recruiting
42 enrolled
Platform Study of ADC Rechallenge in ADC-treated Metastatic Breast Cancer
Phase 2 Recruiting
160 enrolled
I-SPY
Phase 2 Recruiting
5,000 enrolled
Trial of Pre-operative Neratinib and Endocrine Therapy With Trastuzumab in ER-Positive, HER-2 Positive Breast Cancers
Phase 2 Recruiting
30 enrolled
Response Adapted Neoadjuvant Therapy in Gastroesophageal Cancers (RANT-GC Trial)
Phase 1 Recruiting
20 enrolled
A Study of Tucatinib and Trastuzumab in People With Rectal Cancer
Phase 2 Recruiting
37 enrolled
Study of HER2 Directed Dendritic Cell (DC1) Vaccine + Weekly Paclitaxel, Trastuzumab & Pertuzumab
Phase 2 Recruiting
53 enrolled
A Study of Surgery and Radiotherapy in People With Breast Cancer
Phase 2 Recruiting
162 enrolled
An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis
Phase 4 Recruiting
10 enrolled
Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility Study
Phase 2 Recruiting
30 enrolled
H3RAKLES
Phase 2 Recruiting
20 enrolled
TAPUR
Phase 2 Recruiting
4,200 enrolled
Neratinib In Combination With Chemotherapy/Trastuzumab/Pembrolizumab In HER2 Gastroesophageal Cancer
Phase 2 Recruiting
36 enrolled
Neoadjuvant Trastuzumab Deruxtecan (SHR-A1811) + Pertuzumab in HER2+ Breast Cancer
Phase 2 Recruiting
50 enrolled
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
Phase 3 Recruiting
1,524 enrolled
A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer
Phase 2 Recruiting
49 enrolled
ROSETTE
Phase 2 Recruiting
84 enrolled
TAYLOR
Phase 2 Recruiting
200 enrolled
Testing the Use of Ado-Trastuzumab Emtansine Compared to the Usual Treatment (Chemotherapy With Docetaxel Plus Trastuzumab) or Trastuzumab Deruxtecan for Recurrent, Metastatic, or Unresectable HER2-Expressing Salivary Gland Cancers
Phase 2 Recruiting
146 enrolled
RAGE
Phase 1/2 Recruiting
48 enrolled
Identification and Treatment Of Micrometastatic Disease in Stage III Colon Cancer
Phase 3 Recruiting
400 enrolled
TRIFLUOX-DP
Phase 2 Recruiting
73 enrolled
DETERMINE
Phase 2/3 Recruiting
825 enrolled
Concurrent WOKVAC Vaccination, Chemotherapy, and HER2-Targeted Monoclonal Antibody Therapy Before Surgery for the Treatment of Patients With Breast Cancer
Phase 2 Recruiting
25 enrolled
Adjuvant Trastuzumab Plus Neratinib in Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer After Neoadjuvant Trastuzumab Plus Pertuzumab
Phase 3 Recruiting
300 enrolled
Precision Treatment of Recurrent/Metastatic Salivary Gland Carcinoma Guided by Molecular Typing
Phase 2 Recruiting
39 enrolled
ARIADNE
Phase 2 Recruiting
370 enrolled
The Sagittarius Trial
Phase 3 Recruiting
700 enrolled
Multi-omics Sequencing in Neoadjuvant Immunotherapy of Gastrointestinal Tumors
Phase 2 Recruiting
200 enrolled
TRAP-BTC
Phase 2 Recruiting
24 enrolled
ProTarget
Phase 2 Recruiting
300 enrolled
A Randomized, Open-label, Multi-center Phase III Study Comparing the Efficacy of Oral Chemotherapy Combined With Trastuzumab Versus Paclitaxel Combined With Trastuzumab in the Adjuvant Treatment of HER2-positive, Lymph Node-negative Early Breast Cancer Patients(ORCHID-PLUS)
Phase 3 Recruiting
2,306 enrolled
BRE-10
Phase 2 Recruiting
28 enrolled
TAB-2
Phase 3 Recruiting
220 enrolled
The SAPPHO Study: Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer
Phase 2 Recruiting
72 enrolled
MINUTE
Phase 4 Recruiting
679 enrolled
Ribociclib, Tucatinib, and Trastuzumab for the Treatment of HER2 Positive Breast Cancer
Phase 1/2 Recruiting
18 enrolled
SAFIR-ABC10
Phase 3 Recruiting
800 enrolled
SCHOLAR-2
Phase 2 Recruiting
130 enrolled
TUC-TOC
Phase 2 Recruiting
66 enrolled
Genomics Guided Targeted Post-neoadjuvant Therapy in Patients With Early Breast Cancer (COGNITION-GUIDE)
Phase 2 Recruiting
240 enrolled
Pyrotinib Combined With Trastuzumab and Chemotherapy Neoadjuvant Therapy for HER2-positive Breast Cancer
Phase NA Recruiting
30 enrolled
RESPONSE
Phase 2 Recruiting
185 enrolled
Neoadjuvant Chemotherapy Plus Pyrotinib and Trastuzumab for HER2-positive Breast Cancer (NEOTORCH-BREAST05)
Phase 2 Recruiting
33 enrolled
First-line Treatment With RC48 Plus Sintilimab and S-1 in Advanced Gastric Cancer (RCTS2)
Phase 2 Recruiting
110 enrolled
TREAZURE
Phase 1/2 Recruiting
47 enrolled
Cadonilimab Combination Regimen as First-line Treatment for HER2-expressing GC/GEJ Patients
Phase 1/2 Recruiting
90 enrolled
Neoadjuvant Study With Pyrotinib and Trastuzumab and Abraxane in Patients With HER2-enriched Breast Cancer
Phase 2 Recruiting
65 enrolled
IRIS
Phase 2 Recruiting
356 enrolled
The Efficacy and Safety of Pyrotinib, Trastuzumab Combined With Taxanes in the Treatment of Trastuzumab-treated HER2+ Advanced Breast Cancer (ABC).
Phase 4 Recruiting
100 enrolled