Clinical Trials Browser

Phase 1 × Vorinostat × Clear all

NCT00268385 2026-03-18

Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

Phase 1 Active not recruiting

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00336063 2026-03-18

Vorinostat and Azacitidine in Treating Patients With Locally Recurrent or Metastatic Nasopharyngeal Cancer or Nasal Natural Killer T-Cell Lymphoma

Phase 1 Active not recruiting

Lymphoma, Extranodal NK-T-Cell

NCT03742245 2026-03-16

Olaparib in Combination With Vorinostat in Patients With Relapsed/Refractory and/or Metastatic Breast Cancer

Phase 1 Active not recruiting

Breast Neoplasms, Neoplasm Metastasis, Recurrence

NCT01087554 2026-01-16

Sirolimus or Everolimus or Temsirolimus and Vorinostat in Advanced Cancer

Phase 1 Active not recruiting

Advanced Cancer

NCT05317403 2026-01-12

Venetoclax to Augment Epigenetic Modification and Chemotherapy

Phase 1 Recruiting

Other hematologic neoplasm

Leukemia, Myeloid, Acute

NCT03259503 2025-11-10

Olaparib and High-Dose Chemotherapy in Treating Patients With Relapsed or Refractory Lymphomas Undergoing Stem Cell Transplant

Phase 1 Completed

Hodgkin Disease, Lymphoma, T-Cell, Lymphoma, Large B-Cell, Diffuse

NCT01281176 2025-10-20

High-Dose or Low-Dose Vorinostat in Combination With Carboplatin or Paclitaxel in Treating Patients With Advanced Solid Tumors

Phase 1 Active not recruiting

Adult Solid Neoplasm

NCT03263936 2025-10-16

Epigenetic Reprogramming in Relapse/Refractory AML

Phase 1 Completed

37 enrolled 11 charts

Other hematologic neoplasm

Leukemia, Recurrence, Leukemia, Myeloid, Acute

NCT03426891 2025-10-06

Pembrolizumab and Vorinostat Combined With Temozolomide for Newly Diagnosed Glioblastoma

Phase 1 Completed

21 enrolled 12 charts

Brain Neoplasms, Glioblastoma

NCT03150329 2025-09-03

Pembrolizumab and Vorinostat in Patients With Relapsed or Refractory DLBCL, FCL or HL.

Phase 1 Active not recruiting

52 enrolled 13 charts

Lymphoma, Follicular, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse

NCT03843528 2025-08-11

Vorinostat Dose-escalation After Allogeneic Hematopoietic Cell Transplantation

Phase 1 Active not recruiting

MyeloidOther hematologic neoplasm

Myelodysplastic Syndromes, Leukemia, Biphenotypic, Acute, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Juvenile

NCT00838929 2025-05-04

Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases

Phase 1 Completed

17 enrolled 8 charts

BreastCNSThoracic

Brain Neoplasms, Breast Neoplasms, Lung Neoplasms

NCT03332667 2025-04-16

MIBG With Dinutuximab +/- Vorinostat

Phase 1 Completed

45 enrolled 16 charts

Neuroblastoma

NCT02420613 2025-04-02

Vorinostat and Temsirolimus With or Without Radiation Therapy in Treating Younger Patients With Newly Diagnosed or Progressive Diffuse Intrinsic Pontine Glioma

Phase 1 Completed

Diffuse Intrinsic Pontine Glioma

NCT03878524 2024-03-04

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

Phase 1 Terminated

BreastClassical hematologyGastrointestinalGenitourinaryLymphoidMyeloidOther hematologic neoplasmPlasma cell

Anemia, Blast Crisis, Breast Neoplasms, Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Neoplasm Metastasis, Pancreatic Neoplasms, Prostatic Neoplasms, Thrombocytosis, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Myelodysplastic-Myeloproliferative Diseases, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Primary Myelofibrosis

NCT04308330 2023-10-26

NYMC195

Phase 1 Unknown

CNSGastrointestinalGenitourinarySarcoma

Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Hepatoblastoma

NCT00455351 2023-05-08

PRAVO

Phase 1 Completed

Pelvic Neoplasms

NCT01019850 2023-04-10

N2007-03: Vorinostat and 131-I MIBG in Treating Patients With Resistant or Relapsed Neuroblastoma

Phase 1 Completed

Neuroblastoma

NCT01023737 2023-02-13

Hydroxychloroquine + Vorinostat in Advanced Solid Tumors

Phase 1 Completed

Other solid neoplasm

Malignant Solid Tumour

NCT02349867 2022-09-19

Neoadjuvant Chemotherapy Followed by Radiation Therapy and Gemcitabine/Sorafenib/Vorinostat in Pancreatic Cancer

Phase 1 Completed

Gastrointestinal

Pancreatic Neoplasms

NCT00127127 2022-09-13

MK-0683-029

Phase 1 Completed

18 enrolled 24 charts

Neoplasms

NCT02042989 2022-07-11

MLN9708 and Vorinostat in Patients With Advanced p53 Mutant Malignancies

Phase 1 Completed

Advanced Cancers

NCT00867178 2022-01-13

Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System

Phase 1 Completed

Medulloblastoma, Pinealoma

NCT02083250 2022-01-06

Fludarabine Phosphate, Clofarabine, and Busulfan With Vorinostat in Treating Patients With Acute Leukemia in Remission or Relapse Undergoing Donor Stem Cell Transplant

Phase 1 Completed

LymphoidMyeloidOther hematologic neoplasm

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT01038388 2021-11-03

A Study of the Combination Vorinostat With Lenalidomide, Bortezomib and Dexamethasone for Patients With Newly Diagnosed Multiple Myeloma

Phase 1 Completed

Multiple Myeloma

NCT03050450 2021-04-05

Study of Lenalidomide With Vorinostat in Pediatric Patients With High Grade or Progressive CNS Tumors

Phase 1 Terminated

8 enrolled 10 charts

Central Nervous System Neoplasms

NCT01266057 2021-03-04

Sirolimus or Vorinostat and Hydroxychloroquine in Advanced Cancer

Phase 1 Completed

Neoplasms

NCT01169532 2021-02-21

Ridaforolimus and Vorinostat in Treating Patients With Advanced Solid Tumors or Lymphoma

Phase 1 Completed

16 enrolled 7 charts

Lymphoma

NCT00691210 2020-11-20

SAHA

Phase 1 Completed

40 enrolled 13 charts

Hodgkin Disease, Lymphoma, Non-Hodgkin

NCT00821951 2020-11-20

Vorinostat in Combination With Palliative Radiotherapy for Patients With Non-Small Cell Lung Cancer

Phase 1 Completed

17 enrolled 5 charts

Carcinoma, Non-Small-Cell Lung

NCT00642954 2020-11-18

MK-0683-074

Phase 1 Completed

31 enrolled 13 charts

Multiple Myeloma, Recurrence

NCT00729118 2020-05-18

Vorinostat and Lenalidomide After Autologous Stem Cell Transplant in Treating Patients With Multiple Myeloma

Phase 1 Completed

Multiple Myeloma, Neoplasms, Plasma Cell

NCT01059552 2019-11-27

NSCLC

Phase 1 Completed

Lung Neoplasms

NCT00109109 2019-11-14

A Clinical Trial of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Patients With Advanced Multiple Myeloma (0683-004)

Phase 1 Terminated

Multiple Myeloma

NCT01084057 2019-11-05

Ixabepilone and Vorinostat in Treating Patients With Metastatic Breast Cancer

Phase 1 Completed

Breast Neoplasms, Breast Neoplasms, Male

NCT02412475 2019-01-24

Epigenetic Reprogramming in Relapse AML

Phase 1 Terminated

Other hematologic neoplasm

Leukemia, Myeloid, Acute

NCT02108002 2018-09-14

Effect of Vorinostat on Nervous System Hemangioblastomas in Von Hippel-Lindau Disease (Missense Mutation Only)

Phase 1 Completed

von Hippel-Lindau Disease, Hemangioblastoma

NCT00744354 2018-01-18

Vorinostat, Bortezomib, and Doxorubicin Hydrochloride Liposome in Treating Patients With Relapsed or Refractory Multiple Myeloma

Phase 1 Terminated

Multiple Myeloma, Neoplasms, Plasma Cell

NCT00667082 2017-11-22

NPI-0052 and Vorinostat in Patients With Non-small Cell Lung Cancer, Pancreatic Cancer, Melanoma or Lymphoma

Phase 1 Completed

DermatologicGastrointestinalLymphoidPlasma cellThoracic

Carcinoma, Non-Small-Cell Lung, Lymphoma, Melanoma, Multiple Myeloma, Pancreatic Neoplasms

NCT00946673 2017-10-06

Phase I Vorinostat Concurrent With Stereotactic Radiosurgery (SRS) in Brain Metastases From Non-Small Cell Lung Cancer

Phase 1 Completed

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT00788112 2017-08-07

Vorinostat in Treating Women With Ductal Carcinoma in Situ of the Breast

Phase 1 Completed

Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating

NCT01130506 2017-08-02

Decitabine, Vorinostat, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

Phase 1 Completed

Other hematologic neoplasm

Leukemia, Myeloid, Acute

NCT01339871 2017-06-16

Study of Pazopanib and Vorinostat in Patients With Advanced Malignancies

Phase 1 Completed

Advanced Cancer

NCT00731952 2017-05-04

Phase I Study of Induction Therapy With VELCADE and Vorinostat in Patients With Surgically Resectable Non-Small Cell Lung Cancer

Phase 1 Completed

Carcinoma, Non-Small-Cell Lung

NCT00750178 2017-04-07

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MK0683 in Patients With Advanced Cancer (0683-008)

Phase 1 Completed

Neoplasms

NCT00719875 2017-03-03

HDAC Inhibitor Vorinostat (SAHA) With Capecitabine (Xeloda) Using a New Weekly Dose Regimen for Advanced Breast Cancer

Phase 1 Completed

Advanced Breast Cancer

NCT00565227 2016-12-02

Phase I Study of Vorinostat in Combination With Docetaxel in Patients With Advanced and Relapsed Solid Malignancies.

Phase 1 Terminated

GenitourinaryThoracic

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Transitional Cell, Prostatic Neoplasms

NCT00702572 2016-09-22

Carboplatin, Paclitaxel, Bevacizumab and Vorinostat for Patients With Advanced Non-Small Cell Lung Cancer

Phase 1 Terminated

Carcinoma, Non-Small-Cell Lung

NCT00423449 2016-02-04

Clinical Trial of MK0683 in Combination With FDA Approved Cancer Drugs in Patients With Advanced NSCLC (MK0683-058)

Phase 1 Completed

61 enrolled 9 charts

Carcinoma, Non-Small-Cell Lung

NCT01276717 2015-12-03

Study of Carfilzomib and Vorinostat for Relapsed or Refractory Lymphoma

Phase 1 Completed

Lymphoma