Clinical Trials

Phase 1/2 Active not recruiting

Lymphoma, Extranodal NK-T-Cell

NCT00392353 2026-03-18

Vorinostat and Azacitidine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia

135 enrolled

Classical hematologyMyeloidOther hematologic neoplasm

Anemia, Refractory, Anemia, Refractory, with Excess of Blasts, Leukemia, Erythroblastic, Acute, Leukemia, Megakaryoblastic, Acute, Myelodysplastic Syndromes, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic

NCT01522976 2026-03-18

Azacitidine With or Without Lenalidomide or Vorinostat in Treating Patients With Higher-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia

Phase 2 Active not recruiting

282 enrolled 11 charts

Classical hematologyMyeloidOther hematologic neoplasm

GATA2 Deficiency, Anemia, Refractory, with Excess of Blasts, Myelodysplastic Syndromes, Leukemia, Myelomonocytic, Chronic

NCT01587352 2026-03-18

Vorinostat in Treating Patients With Metastatic Melanoma of the Eye

Phase 2 Active not recruiting

40 enrolled

Dermatologic

Uveal Melanoma

NCT01281176 2025-10-20

High-Dose or Low-Dose Vorinostat in Combination With Carboplatin or Paclitaxel in Treating Patients With Advanced Solid Tumors

Phase 1 Active not recruiting

20 enrolled

Adult Solid Neoplasm

NCT01413750 2024-11-12

Carboplatin and Paclitaxel With or Without Vorinostat in Treating Patients With Advanced Non-Small Cell Lung Cancer

23 enrolled 10 charts

Stage IIIA Lung Non-Small Cell Cancer AJCC v7

NCT01236560 2024-02-20

Vorinostat, Temozolomide, or Bevacizumab in Combination With Radiation Therapy Followed by Bevacizumab and Temozolomide in Young Patients With Newly Diagnosed High-Grade Glioma

Phase 2/3 Completed

101 enrolled 15 charts

Astrocytoma, Spinal Cord Neoplasms

NCT01193842 2023-11-21

Vorinostat and Combination Chemotherapy With Rituximab in Treating Patients With HIV-Related Diffuse Large B-Cell Non-Hodgkin Lymphoma or Other Aggressive B-Cell Lymphomas

107 enrolled 24 charts

Plasmablastic Lymphoma, Lymphoma, Follicular, HIV Infections, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Primary Effusion

NCT00731731 2022-08-04

Vorinostat, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

125 enrolled 12 charts

Glioblastoma, Gliosarcoma

NCT00867178 2022-01-13

Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System

33 enrolled

Medulloblastoma, Pinealoma

NCT01189266 2021-10-28

Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma

79 enrolled 17 charts

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Gliosarcoma

NCT00324740 2021-02-23

Vorinostat and Isotretinoin in Treating Patients With Advanced Kidney Cancer

Phase 1/2 Terminated

14 enrolled 8 charts

Carcinoma, Renal Cell

NCT01175980 2020-08-03

Vorinostat in Treating Patients With Locally Advanced, Recurrent, or Metastatic Adenoid Cystic Carcinoma

30 enrolled 16 charts

Head & Neck

Salivary Gland Neoplasms, Tongue Neoplasms

NCT00262834 2020-02-19

Vorinostat in Treating Women Who Are Undergoing Surgery For Newly Diagnosed Stage I -III Breast Cancer

54 enrolled 7 charts

Breast

Breast Neoplasms

NCT00132067 2019-07-23

Vorinostat in Treating Patients With Recurrent or Persistent Ovarian Epithelial or Primary Peritoneal Cavity Cancer

60 enrolled

Gynecologic

Carcinoma, Ovarian Epithelial

NCT00895934 2019-05-23

Vorinostat, Azacitidine, and Gemtuzumab Ozogamicin for Older Patients With Relapsed or Refractory AML

52 enrolled 12 charts

Congenital Abnormalities, Leukemia, Erythroblastic, Acute, Leukemia, Megakaryoblastic, Acute, Leukemia, Monocytic, Acute, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Acute

NCT00121225 2019-01-29

Vorinostat in Treating Patients With Metastatic or Unresectable Melanoma

32 enrolled 11 charts

Dermatologic

Uveal Melanoma, Melanoma

NCT01802333 2018-12-19

Cytarabine and Daunorubicin Hydrochloride or Idarubicin and Cytarabine With or Without Vorinostat in Treating Younger Patients With Previously Untreated Acute Myeloid Leukemia

Phase 3 Completed

754 enrolled 20 charts

Leukemia, Myeloid, Acute

NCT02108002 2018-09-14

Effect of Vorinostat on Nervous System Hemangioblastomas in Von Hippel-Lindau Disease (Missense Mutation Only)

7 enrolled

von Hippel-Lindau Disease, Hemangioblastoma

NCT00703664 2018-08-07

Bortezomib and Vorinostat in Treating Patients With Recurrent Mantle Cell Lymphoma or Recurrent and/or Refractory Diffuse Large B-Cell Lymphoma

65 enrolled 14 charts

Lymphoma, Non-Hodgkin, Lymphoma, Mantle-Cell

NCT01266031 2018-07-31

Phase I/II Adaptive Randomized Trial of Bevacizumab Versus Bevacizumab Plus Vorinostat in Adults With Recurrent Glioblastoma

96 enrolled 15 charts

Glioblastoma, Glioma

NCT01789255 2018-07-24

Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies

Classical hematologyLymphoidMyeloidOther hematologic neoplasm

12 enrolled 11 charts

Chromosome 5q Deletion Syndrome, Congenital Abnormalities, Anemia, Refractory, Anemia, Refractory, with Excess of Blasts, Burkitt Lymphoma, Graft vs Host Disease, Hodgkin Disease, Leukemia, Hairy Cell, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Myeloproliferative Disorders, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Intraocular Lymphoma

NCT01567709 2018-04-11

Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma

DermatologicLymphoidOther hematologic neoplasm

34 enrolled

Burkitt Lymphoma, Hodgkin Disease, Immunoblastic Lymphadenopathy, Leukemia, Hairy Cell, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Mycosis Fungoides, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, T-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, T-Cell, Cutaneous, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Leukemia, Large Granular Lymphocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Intraocular Lymphoma

NCT00253630 2018-03-06

Vorinostat in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma

37 enrolled 8 charts

Lymphoma, Follicular, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell

NCT00138203 2018-01-30

Suberoylanilide Hydroxamic Acid in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer

16 enrolled 9 charts

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT01342757 2018-01-29

Magnetic Resonance Spectroscopy Imaging in Predicting Response to Vorinostat and Temozolomide in Patients With Recurrent or Progressive Glioblastoma

Phase NA Completed

12 enrolled 8 charts

Brain Neoplasms, Depression, Glioblastoma

NCT00278395 2017-11-14

Vorinostat in Treating Patients With Kidney Cancer

14 enrolled 7 charts

Carcinoma, Renal Cell

NCT00589472 2017-10-06

TARGET

19 enrolled 12 charts

Prostatic Neoplasms

NCT01130506 2017-08-02

Decitabine, Vorinostat, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

17 enrolled

Leukemia, Myeloid, Acute

NCT01267240 2017-04-14

Capecitabine and Vorinostat in Treating Patients With Recurrent and/or Metastatic Head and Neck Cancer

25 enrolled 9 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT00324870 2016-01-13

Vorinostat and Bevacizumab in Treating Patients With Unresectable or Metastatic Kidney Cancer

37 enrolled 6 charts

Carcinoma, Renal Cell

NCT01208454 2015-11-24

Vorinostat and Isotretinoin in Treating Patients With High-Risk Refractory or Recurrent Neuroblastoma

29 enrolled

Neuroblastoma

NCT00368875 2015-11-05

Phase I-II Study of Vorinostat, Paclitaxel, and Bevacizumab in Metastatic Breast Cancer

54 enrolled 9 charts

Breast

Breast Neoplasms, Breast Neoplasms, Male

NCT00132002 2015-03-19

Suberoylanilide Hydroxamic Acid in Treating Patients With Progressive Stage IV Breast Cancer

14 enrolled 6 charts

Breast

Breast Neoplasms, Breast Neoplasms, Male

NCT00363883 2015-02-13

Vorinostat in Treating Patients With Locally Recurrent or Metastatic Cancer of the Urothelium

14 enrolled 6 charts

Localized Transitional Cell Cancer of the Renal Pelvis and Ureter

NCT00481078 2014-10-30

Vorinostat, Carboplatin, and Paclitaxel in Treating Patients With Advanced or Metastatic Non-Small Cell Lung Cancer

94 enrolled 8 charts

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT00275080 2014-08-27

Vorinostat and Decitabine in Treating Patients With Advanced Solid Tumors or Relapsed or Refractory Non-Hodgkin's Lymphoma, Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, or Chronic Myelogenous Leukemia

LymphoidOther hematologic neoplasm

80 enrolled

Congenital Abnormalities, Blast Crisis, Burkitt Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Acute, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00134043 2014-08-11

Suberoylanilide Hydroxamic Acid in Treating Patients With Metastatic and/or Locally Advanced or Locally Recurrent Thyroid Cancer

19 enrolled 11 charts

EndocrineHead & Neck

Thyroid Cancer, Papillary, Thyroid Neoplasms, Adenocarcinoma, Follicular, Carcinoma, Medullary

NCT00217412 2014-06-17

Vorinostat With or Without Isotretinoin in Treating Young Patients With Recurrent or Refractory Solid Tumors, Lymphoma, or Leukemia

CNSLymphoidOther hematologic neoplasmSarcoma

60 enrolled

Burkitt Lymphoma, Medulloblastoma, Neuroblastoma, Recurrence, Lymphoma, Large B-Cell, Diffuse, Rhabdoid Tumor, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile, Dendritic Cell Sarcoma, Interdigitating

NCT00330161 2014-05-26

Vorinostat in Treating Patients With Progressive Metastatic Prostate Cancer

29 enrolled 8 charts

Prostatic Neoplasms

NCT00132028 2014-05-23

Vorinostat in Treating Patients With Relapsed or Refractory Advanced Hodgkin's Lymphoma

27 enrolled 9 charts

Hodgkin Disease

NCT00238303 2014-05-23

Vorinostat in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme

103 enrolled 10 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00305773 2014-05-19

Vorinostat in Treating Patients With Acute Myeloid Leukemia

37 enrolled 11 charts

Congenital Abnormalities, Leukemia, Erythroblastic, Acute, Leukemia, Megakaryoblastic, Acute, Leukemia, Monocytic, Acute, Leukemia, Myeloid, Acute, Leukemia, Promyelocytic, Acute, Leukemia, Myelomonocytic, Acute

NCT00641706 2014-05-14

Vorinostat and Bortezomib in Treating Patients With Progressive, Recurrent Glioblastoma Multiforme

44 enrolled 9 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00937495 2014-05-14

Vorinostat and Bortezomib in Treating Patients With Advanced Soft Tissue Sarcoma

16 enrolled 6 charts

Sarcoma

NCT00227513 2014-02-24

Vorinostat and Bortezomib in Treating Patients With Metastatic or Unresectable Solid Tumors

66 enrolled

Other solid neoplasm

Unspecified Adult Solid Tumor, Protocol Specific

NCT00324480 2014-02-24

Vorinostat and Alvocidib in Treating Patients With Advanced Solid Tumors

60 enrolled

Other solid neoplasm

Unspecified Adult Solid Tumor, Protocol Specific

NCT00499811 2014-02-24

Vorinostat in Treating Patients With Metastatic or Unresectable Solid Tumors or Lymphoma and Liver Dysfunction

DermatologicLymphoidOther hematologic neoplasm

15 enrolled

Burkitt Lymphoma, Hodgkin Disease, Immunoblastic Lymphadenopathy, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Mycosis Fungoides, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Intraocular Lymphoma

NCT00243100 2013-12-16

Vorinostat and Gemcitabine in Treating Patients With Metastatic or Unresectable Solid Tumors