Clinical Trials Browser

OTHER × bintrafusp alfa protein, human × Clear all

NCT04789668 2026-03-18

Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain Metastases

Phase 1/2 Terminated

8 enrolled 13 charts

BreastCNSDermatologicOther hematologic neoplasmThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Hematologic Neoplasms, Triple Negative Breast Neoplasms

NCT04708067 2026-03-05

Hypofractionated Radiation Therapy and Bintrafusp Alfa for the Treatment of Advanced Intrahepatic Cholangiocarcinoma

Phase 1 Active not recruiting

Gastrointestinal

Cholangiocarcinoma

NCT05005429 2025-12-23

BIMES

Phase 2 Completed

47 enrolled 9 charts

Other solid neoplasmThoracic

Mesothelioma, Malignant, Mesothelioma

NCT04396535 2025-11-17

Docetaxel With or Without Bintrafusp Alfa for the Treatment of Advanced Non-small Cell Lung Cancer

Phase 2 Terminated

10 enrolled 17 charts

Lung Neoplasms

NCT04874311 2025-08-13

TRUST

Phase 2 Recruiting

Tertiary Lymphoid Structures, Neoplasm Metastasis, Sarcoma

NCT03436563 2024-11-27

M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite Instability

Phase 1/2 Completed

4 enrolled 7 charts

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms, Microsatellite Instability

NCT04220775 2024-11-07

Bintrafusp Alfa and Stereotactic Body Radiation Therapy for the Treatment of Recurrent or Second Primary Head and Neck Squamous Cell Cancer

Phase 1/2 Terminated

3 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck

NCT03620201 2024-10-22

M7824 in Treating Patients With Stage II-III HER2 Positive Breast Cancer

Phase 1 Completed

Anatomic Stage II Breast Cancer AJCC v8

NCT04481256 2024-07-26

TAPESTRY

Phase NA Recruiting

Gastrointestinal

Carcinoma, Squamous Cell, Esophageal Neoplasms

NCT04396886 2024-05-09

Bintrafusp Alfa in Previously Treated Patients With R/M Non-keratinizing NPC

Phase 2 Completed

Nasopharyngeal Carcinoma, Neoplasm Metastasis, Recurrence

NCT04756505 2023-12-27

Immunotherapy (NHS-IL12 & Bintrafusp Alfa) and Radiation Therapy for the Treatment of Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer, the REINA Trial

Phase 1 Withdrawn

Breast Neoplasms

NCT04971187 2023-08-01

Bintrafusp Alfa With Chemotherapy for Tyrosine Kinase Inhibitor-Resistant EGFR-Mutant Non-small Cell Lung Cancer

Phase 2 Terminated

3 enrolled 8 charts

Lung Neoplasms

NCT04297748 2023-01-17

Bioimaging Study of 89Zr-M7824 in NSCLC

Phase 1/2 Terminated

Carcinoma, Non-Small-Cell Lung, Camurati-Engelmann Syndrome

NCT04560686 2022-07-28

Bintrafusp Alfa Before Surgery for the Treatment of Untreated Resectable Non-small Cell Lung Cancer

Phase 2 Terminated

2 enrolled 7 charts

Lung Neoplasms

NCT04428047 2022-04-06

ICING

Phase 2 Terminated

Squamous Cell Carcinoma of Head and Neck

NCT03524170 2022-03-07

Radiation Therapy and M7824 in Treating Patients With Metastatic Hormone Receptor Positive, HER2 Negative Breast Cancer

Phase 1 Completed

Breast Neoplasms