Clinical Trials

21 enrolled

Leukemia, Myeloid, Acute

NCT03280030 2025-03-20

A Study of Midostaurin Efficacy and Safety in Newly Diagnosed Patients With FLT3-mutated AML

67 enrolled 21 charts

MyeloidOther hematologic neoplasm

Leukemia, Myeloid, Acute

NCT03092674 2025-01-16

Azacitidine With or Without Nivolumab or Midostaurin, or Decitabine and Cytarabine Alone in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Phase 2/3 Completed

76 enrolled 16 charts

GATA2 Deficiency, Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT03379727 2024-02-29

Study to Assess the Safety and Efficacy of Midostaurin (PKC412) in Combination With Standard Chemotherapy During Induction and Consolidation Followed by 12 Months of Maintenance Monotherapy in Patients With Newly-diagnosed FMS-like Tyrosine 3 (FLT3) Kinase Receptor-mutated Acute Myeloid Leukemia.

Phase 3 Completed

301 enrolled 9 charts

Leukemia, Myeloid, Acute

NCT04075747 2023-10-16

V-FAST

57 enrolled

Leukemia, Myeloid, Acute

NCT03512197 2023-08-21

A Global Study of the Efficacy and Safety of Midostaurin + Chemotherapy in Newly Diagnosed Patients With FLT3 Mutation Negative (FLT3-MN) Acute Myeloid Leukemia (AML)

Phase 3 Completed

511 enrolled 26 charts

Leukemia, Myeloid, Acute, Neoplasm, Residual

NCT01883362 2021-03-17

RADIUS

60 enrolled 17 charts

Leukemia, Myeloid, Acute

NCT00093600 2020-12-19

PKC412, Daunorubicin, and Cytarabine in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

69 enrolled

Congenital Abnormalities, Leukemia, Myeloid, Acute

NCT02078609 2020-12-17

A Safety and Efficacy Study of LGH447 in Patients With Acute Myeloid Leukemia (AML) or High Risk Myelodysplastic Syndrome (MDS)

MyeloidOther hematologic neoplasm

70 enrolled

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT01830361 2020-08-06

MIDOKIT

18 enrolled

Leukemia, Myeloid, Acute

NCT01477606 2020-06-04

Protocol in Acute Myeloid Leukemia With FLT3-ITD

451 enrolled

Leukemia, Myeloid, Acute

NCT01282502 2018-12-12

Midostaurin (PKC412) for Locally Advanced Rectal Cancer

19 enrolled

Gastrointestinal

Rectal Neoplasms

NCT00782067 2018-11-15

Efficacy and Safety of Midostaurin in Patients With Aggressive Systemic Mastocytosis or Mast Cell Leukemia

LymphoidMyeloidOther hematologic neoplasm

116 enrolled 16 charts

Aggression, Leukemia, Leukemia, Mast-Cell, Mastocytosis, Systemic

NCT01202877 2018-10-16

PKC412 and 5-Azacytidine

Phase 1/2 Completed

54 enrolled 8 charts

MyeloidOther hematologic neoplasm

Leukemia, Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT01161550 2013-07-23

CLAG ATRA AML

11 enrolled

Leukemia, Myeloid, Acute

NCT01130662 2013-03-26

Combination of Decitabine and Midostaurin in Patients Older Than 60 With Newly Diagnosed or Relapsed Refractory Acute Myeloid Leukemia

16 enrolled