Clinical Trials

2,900 enrolled

Gynecologic

Fallopian Tube Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Endometrial Neoplasms

NCT05638295 2026-03-17

Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)

105 enrolled

Tumor-Agnostic

Neoplasm Metastasis

NCT07012031 2026-03-17

Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

Phase 1/2 Recruiting

37 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT05920356 2026-02-27

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

Phase 3 Recruiting

750 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasms

NCT06252649 2026-02-27

CodeBreaK 301

Phase 3 Recruiting

450 enrolled

Gastrointestinal

Neoplasms, Colorectal Neoplasms

NCT06333951 2026-02-19

AMG 193 Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).

500 enrolled

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT06582771 2026-02-05

A Study of Sotorasib in People With Non-Small Cell Lung Cancer

39 enrolled

Non Small Lung Cancer

NCT05815173 2025-12-30

Ladarixin With Sotorasib in Advanced NSCLC

40 enrolled

Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation

NCT05118854 2025-10-20

A Phase II Study of Neoadjuvant Sotorasib in Combination With Cisplatin or Carboplatin and Pemetrexed for Surgically Resectable Stage IIA-IIIB Non-Squamous Non-Small Cell Lung Cancer With a KRAS p.G12C Mutation

27 enrolled

Lung Neoplasms

NCT07143513 2025-09-12

Real World Evaluation of Sotorasib Among Chinese Non-Small Cell Lung Cancer Patients

Recruiting

115 enrolled

Carcinoma, Non-Small-Cell Lung

NCT06249282 2025-06-17

Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer

15 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT05631249 2025-05-08

CODEBREAK-IGR

40 enrolled

Carcinoma, Non-Small-Cell Lung

NCT05398094 2025-04-10

MERIT-lung

19 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT05036291 2025-03-05

A Study of NB004 as Monotherapy or Combination Therapy in Patients With Advanced Solid Tumors