Clinical Trials

2,900 enrolled

Gynecologic

Fallopian Tube Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Endometrial Neoplasms

NCT05638295 2026-03-17

Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)

105 enrolled

Tumor-Agnostic

Neoplasm Metastasis

NCT07012031 2026-03-17

Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

Phase 1/2 Recruiting

37 enrolled

Phase 1/2 Active not recruiting

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT03600883 2026-03-16

A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreaK 100)

713 enrolled 1 FDA

KRAS p.G12C Mutant Advanced Solid Tumors

NCT05920356 2026-02-27

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

Phase 3 Recruiting

750 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasms

NCT06252649 2026-02-27

CodeBreaK 301

Phase 3 Recruiting

450 enrolled

Phase EARLY_PHASE1 Not yet recruiting

Neoplasms, Colorectal Neoplasms

NCT07318389 2026-02-27

ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal Cancer

100 enrolled

Colorectal Neoplasms

NCT06333951 2026-02-19

AMG 193 Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).

500 enrolled

Phase 3 Active not recruiting

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT05198934 2026-02-06

CodeBreak300

160 enrolled 1 FDA

Colorectal Neoplasms

NCT06582771 2026-02-05

A Study of Sotorasib in People With Non-Small Cell Lung Cancer

39 enrolled

Phase 3 Active not recruiting

Non Small Lung Cancer

NCT06497556 2026-01-20

Krascendo 1

338 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT05815173 2025-12-30

Ladarixin With Sotorasib in Advanced NSCLC

40 enrolled

Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation

NCT05313009 2025-12-16

Tarlox and Sotorasib in Patients With KRAS G12C Mutations

Phase 1/2 Terminated

5 enrolled 9 charts

Phase 1 Active not recruiting

Carcinoma, Non-Small-Cell Lung

NCT04185883 2025-10-22

Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)

610 enrolled

Other solid neoplasmSarcoma

Advanced Solid Tumors

NCT05118854 2025-10-20

A Phase II Study of Neoadjuvant Sotorasib in Combination With Cisplatin or Carboplatin and Pemetrexed for Surgically Resectable Stage IIA-IIIB Non-Squamous Non-Small Cell Lung Cancer With a KRAS p.G12C Mutation

27 enrolled

Phase 3 Active not recruiting

Lung Neoplasms

NCT04303780 2025-10-14

Study to Compare AMG 510 "Proposed INN Sotorasib" With Docetaxel in Non Small Cell Lung Cancer (NSCLC) (CodeBreak 200).

345 enrolled 11 charts

Phase 1/2 Active not recruiting

KRAS p, G12c Mutated /Advanced Metastatic NSCLC

NCT04892017 2025-10-10

A Phase 1/2 Study of Inlexisertib (DCC-3116) in Patients With RAS/MAPK Pathway Mutant Solid Tumors

144 enrolled

Phase 1 Active not recruiting

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT04380753 2025-07-23

AMG 510 Ethnic Sensitivity Study (CodeBreaK 105).

12 enrolled 12 charts

Advanced/Metastatic Solid Tumors With KRAS p.G12C Mutation

NCT06249282 2025-06-17

Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer

15 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT05631249 2025-05-08

CODEBREAK-IGR

40 enrolled

Carcinoma, Non-Small-Cell Lung

NCT05374538 2025-05-01

VIC-1911 Monotherapy in Combination With Sotorasib for the Treatment of KRAS G12C-Mutant Non-Small Cell Lung Cancer

Phase 1 Terminated

3 enrolled 13 charts

Other solid neoplasmThoracic

Carcinoma, Non-Small-Cell Lung

NCT04720976 2025-04-11

JAB-3312 Based Combination Therapy in Adult Patients With Advanced Solid Tumors

Phase 1/2 Completed

58 enrolled

Solid Tumor

NCT05398094 2025-04-10

MERIT-lung

19 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT05036291 2025-03-05

A Study of NB004 as Monotherapy or Combination Therapy in Patients With Advanced Solid Tumors

120 enrolled

Advanced Solid Tumor

NCT06068153 2024-11-20

AMBER

Phase 2 Withdrawn

Carcinoma, Non-Small-Cell Lung

NCT04092673 2024-05-21

Zotatifin

Phase 1/2 Recruiting

30 enrolled

Classical hematologyThoracic

Solid Tumor, Adult

NCT06314763 2024-04-30

ROSIE

Phase 4 Completed

21 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Venous Thromboembolism

NCT05815186 2024-03-29

Ladarixin With Sotorasib in Advanced NSCLC - Phase II

Phase 2 Withdrawn

Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation

NCT06127940 2023-11-13

K-SAB

Phase 1 Unknown

20 enrolled

Non-small Cell Lung Cancer Metastatic

NCT05311709 2023-11-09

SOLUCOM

Phase 2 Unknown

100 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasms

NCT05180422 2023-10-18

A Phase I/II Study of AMG 510 in Combination With MVASI in Patients With Advanced, Unresectable or Metastatic KRAS G12C Mutant NSCLC With Asymptomatic Brain Metastasis

Phase 1/2 Withdrawn

Carcinoma, Non-Small-Cell Lung

NCT05993455 2023-08-15

A Phase 2 Basket Trial in Which Patients With Advanced Solid Tumors Carrying the KRAS G12C mUtation Receive Treatment With a Combination of Sotorasib and Panitumumab

Phase 2 Unknown

24 enrolled

Efficacy

NCT05045638 2023-08-14

Effect of Coadministration of Sotorasib on the Pharmacokinetics of Rosuvastatin in Healthy Participants

Phase 1 Completed

13 enrolled 14 charts

Healthy Participants

NCT04959981 2023-07-25

HERKULES-2

Phase 1 Completed

24 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Noonan Syndrome, Thoracic Neoplasms

NCT05400577 2023-07-17

Sotorasib in KRAS G12C Mutated, Resectable, Stage Ib-IIIA NSCLC

Phase 2 Withdrawn

Carcinoma, Non-Small-Cell Lung

NCT05251038 2023-05-11

Study of Sotorasib Combined With Chemotherapy for Second Line Treatment of Pancreas Cancer

Phase 1/2 Withdrawn

Pancreatic Neoplasms

NCT05451056 2022-07-11

breakthrough

Phase 2 Unknown

37 enrolled