Clinical Trials

60 enrolled 6 charts

Breast Neoplasms, Breast Neoplasms, Male

NCT00026104 2020-10-30

Combination Chemotherapy Plus Radiation Therapy With or Without Tipifarnib in Treating Patients With Locally Advanced Pancreatic Cancer

154 enrolled

Gastrointestinal

Pancreatic Neoplasms

NCT00050986 2020-09-22

Phase I/II Evaluation of Temozolomide and ZARNESTRA (R115777) for Recurrent and Progressive Glioblastoma Multiforme

55 enrolled 6 charts

CNS

Brain Neoplasms, Central Nervous System Diseases, Glioblastoma

NCT00077519 2020-04-15

Tipifarnib and Radiation Therapy in Treating Patients With Unresectable Locally Advanced Pancreatic Cancer

18 enrolled

Gastrointestinal

Pancreatic Neoplasms

NCT00082888 2020-04-13

Tipifarnib in Treating Patients With Relapsed or Refractory Lymphoma

LymphoidOther hematologic neoplasm

93 enrolled 12 charts

Hodgkin Disease, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, T-Cell, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

NCT00004009 2019-11-07

R115777 in Treating Patients With Refractory or Recurrent Acute Leukemia or Chronic Myelogenous Leukemia

LymphoidOther hematologic neoplasm

Blast Crisis, Leukemia, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Acute, Leukemia, Promyelocytic, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00025480 2019-03-13

Tipifarnib Plus Radiation Therapy After Combination Chemotherapy in Treating Patients With Stage III Non-Small Cell Lung Cancer

12 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00082810 2018-11-01

Tipifarnib and Fulvestrant in Hormone Receptor-Positive Metastatic Breast Cancer

33 enrolled 10 charts

Breast Neoplasms

NCT00335764 2018-07-02

Sorafenib Combined With Erlotinib, Tipifarnib, or Temsirolimus in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma

92 enrolled 24 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00005859 2018-06-26

Tipifarnib in Treating Patients With Recurrent or Progressive Malignant Glioma

136 enrolled

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT02210858 2018-06-04

Tipifarnib in Treating Patients With Chronic Myeloid Leukemia, Chronic Myelomonocytic Leukemia, or Undifferentiated Myeloproliferative Disorders

MyeloidOther hematologic neoplasm

31 enrolled

Myeloproliferative Disorders, Recurrence, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myelomonocytic, Chronic, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative

NCT00085553 2018-05-18

Tipifarnib and Erlotinib Hydrochloride in Treating Patients With Advanced Solid Tumors

29 enrolled

Solid Neoplasm

NCT00021541 2018-04-17

R115777 to Treat Children With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas

62 enrolled 13 charts

CNS

Neurofibroma, Neurofibromatosis 1, Neurofibromatoses, Neurofibroma, Plexiform

NCT00244972 2017-04-27

Tipifarnib and Sorafenib Tosylate in Treating Patients With Biopsiable Advanced Cancer

74 enrolled

Other neoplasm

Advanced Malignant Neoplasm

NCT00093990 2016-09-14

Tipifarnib Versus Best Supportive Care in the Treatment of Newly Diagnosed Acute Myeloid Leukemia (AML)

Phase 3 Completed

457 enrolled

Leukemia, Myeloid, Acute

NCT00047216 2015-07-23

Tipifarnib in Treating Patients With Recurrent Bladder Cancer

Genitourinary

Urinary Bladder Neoplasms

NCT00070252 2015-05-04

Neoadjuvant Tipifarnib, Docetaxel, and Capecitabine in Treating Patients With Locally Advanced or Metastatic Solid Tumors or Stage IIIA or Stage IIIB Breast Cancer

53 enrolled

Breast Neoplasms, Breast Neoplasms, Male, Inflammatory Breast Neoplasms

NCT00049387 2015-04-15

Tipifarnib, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma

19 enrolled

Glioblastoma, Gliosarcoma

NCT00383474 2015-04-15

Tipifarnib and Bortezomib in Treating Patients With Acute Leukemia or Chronic Myelogenous Leukemia in Blast Phase

LymphoidOther hematologic neoplasm

35 enrolled

Blast Crisis, Leukemia, Erythroblastic, Acute, Leukemia, Megakaryoblastic, Acute, Leukemia, Monocytic, Acute, Recurrence, Leukemia, Myeloid, Acute, Leukemia, Basophilic, Acute, Leukemia, Eosinophilic, Acute, Leukemia, Myelomonocytic, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT01361464 2015-04-08

Tipifarnib in Treating Older Patients With Acute Myeloid Leukemia

21 enrolled 8 charts

Leukemia, Erythroblastic, Acute, Leukemia, Megakaryoblastic, Acute, Leukemia, Monocytic, Acute, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Acute

NCT00972712 2015-03-10

Protocol of the Combination of Bortezomib and Tipifarnib for Relapsed or Refractory Multiple Myeloma

12 enrolled

Plasma cell

Multiple Myeloma

NCT00100750 2015-01-13

Tipifarnib and Gemcitabine Hydrochloride in Treating Women With Metastatic Breast Cancer

31 enrolled

Breast Neoplasms

NCT00096122 2014-05-26

Idarubicin, Cytarabine, and Tipifarnib in Treating Patients With Newly Diagnosed Myelodysplastic Syndromes or Acute Myeloid Leukemia

Classical hematologyOther hematologic neoplasm

95 enrolled 5 charts

Congenital Abnormalities, Anemia, Refractory, with Excess of Blasts, Leukemia, Erythroblastic, Acute, Leukemia, Megakaryoblastic, Acute, Leukemia, Monocytic, Acute, Leukemia, Myeloid, Acute, Leukemia, Basophilic, Acute, Leukemia, Eosinophilic, Acute, Leukemia, Myelomonocytic, Chronic, Leukemia, Myelomonocytic, Acute

NCT00281957 2014-05-20

Sorafenib With Either Temsirolimus or Tipifarnib in Treating Patients With Stage IV Malignant Melanoma That Cannot Be Removed By Surgery

109 enrolled 8 charts

Dermatologic

Melanoma

NCT00005845 2013-12-16

Tipifarnib in Treating Patients With Myelodysplastic Syndromes

Classical hematologyOther hematologic neoplasm

65 enrolled

Anemia, Refractory, Anemia, Refractory, with Excess of Blasts, Leukemia, Myelomonocytic, Chronic

NCT00006376 2013-12-04

R115777 in Treating Patients With Advanced Bladder Cancer

Classical hematologyMyeloidOther hematologic neoplasm

Genitourinary

Urinary Bladder Neoplasms

NCT00454480 2013-08-26

Combination Chemotherapy With or Without Gemtuzumab Ozogamicin or Tipifarnib in Treating Patients With Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes

Phase 2/3 Completed

2,000 enrolled

Congenital Abnormalities, Anemia, Refractory, with Excess of Blasts, Leukemia, Erythroblastic, Acute, Leukemia, Leukemia, Megakaryoblastic, Acute, Leukemia, Monocytic, Acute, Myelodysplastic Syndromes, Leukemia, Myeloid, Acute, Leukemia, Basophilic, Acute, Leukemia, Eosinophilic, Acute, Leukemia, Myelomonocytic, Acute

NCT00005848 2013-07-11

R115777 in Treating Patients With Progressive, Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy

7 enrolled

Genitourinary

Prostatic Neoplasms

NCT00052728 2013-06-19

Tipifarnib Plus Tamoxifen in Treating Women With Metastatic Breast Cancer

Breast Neoplasms

NCT00049114 2013-06-06

Tipifarnib, Doxorubicin, and Cyclophosphamide in Treating Women With Locally Advanced Breast Cancer

62 enrolled

Breast Neoplasms, Inflammatory Breast Neoplasms

NCT00060125 2013-06-05

Tipifarnib in Treating Patients With Metastatic Malignant Melanoma

40 enrolled

Dermatologic

Melanoma

NCT00047190 2013-06-04

Tipifarnib in Treating Patients With Myelofibrosis and Myeloid Metaplasia

35 enrolled

Myeloid

Polycythemia Vera, Thrombocythemia, Essential, Primary Myelofibrosis

NCT00055757 2013-06-04

Tipifarnib, Gemcitabine, and Cisplatin in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer

48 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT00025038 2013-04-11

Combination Chemotherapy Followed By Donor Bone Marrow or Umbilical Cord Blood Transplant in Treating Children With Newly Diagnosed Juvenile Myelomonocytic Leukemia

100 enrolled

Leukemia, Myelomonocytic, Juvenile

NCT00058097 2013-04-09

Tipifarnib and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

54 enrolled

Glioblastoma, Gliosarcoma

NCT00027872 2013-03-25

Tipifarnib in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia

125 enrolled

Congenital Abnormalities, Leukemia, Erythroblastic, Acute, Leukemia, Megakaryoblastic, Acute, Leukemia, Monocytic, Acute, Leukemia, Myeloid, Acute, Leukemia, Basophilic, Acute, Leukemia, Eosinophilic, Acute, Leukemia, Myelomonocytic, Acute

NCT00077363 2013-02-27

Capecitabine and Tipifarnib in Treating Women With Taxane-Resistant Metastatic Breast Cancer

70 enrolled

Breast Neoplasms

NCT00005842 2013-02-11

Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer

BreastCNSEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

24 enrolled

Thyroid Cancer, Papillary, Anus Neoplasms, Appendiceal Neoplasms, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Vipoma, Esophageal Neoplasms, Gallbladder Neoplasms, Glucagonoma, Carcinoma, Hepatocellular, Insulinoma, Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms, Parathyroid Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Somatostatinoma, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Gastrinoma, Pleural Effusion, Malignant, Endometrial Neoplasms, Adenocarcinoma, Follicular, Adrenocortical Carcinoma, Carcinoma, Islet Cell, Carcinoma, Medullary, Breast Neoplasms, Male, Meningeal Carcinomatosis, Inflammatory Breast Neoplasms, Thyroid Carcinoma, Anaplastic

NCT00005843 2013-02-11

R115777 in Treating Patients Who Have Metastatic Pancreatic Cancer

40 enrolled

Gastrointestinal

Pancreatic Neoplasms

NCT00005967 2013-02-11

Tipifarnib in Treating Patients With Advanced Hematologic Cancer

Classical hematologyLymphoidMyeloidOther hematologic neoplasmPlasma cell

36 enrolled

Pdgfra-Associated Chronic Eosinophilic Leukemia, Anemia, Refractory, with Excess of Blasts, Blast Crisis, Burkitt Lymphoma, Hodgkin Disease, Leukemia, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Polycythemia Vera, Thrombocythemia, Essential, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Neutrophilic, Chronic, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Neoplasms, Plasma Cell, Primary Myelofibrosis

NCT00101296 2013-02-04

Tipifarnib in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

30 enrolled

Congenital Abnormalities, Leukemia, Erythroblastic, Acute, Leukemia, Megakaryoblastic, Acute, Leukemia, Monocytic, Acute, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Acute

NCT00050141 2013-02-01

Study of Letrozole Plus Tipifarnib or Placebo in the Treatment of Advanced Breast Cancer

121 enrolled

Breast Neoplasms

NCT00093418 2013-01-15

S0432 Tipifarnib in Treating Older Patients With Acute Myeloid Leukemia

296 enrolled

Congenital Abnormalities, Leukemia, Erythroblastic, Acute, Leukemia, Megakaryoblastic, Acute, Leukemia, Monocytic, Acute, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Acute

NCT00112853 2013-01-09

Tipifarnib and Etoposide in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia

100 enrolled

Congenital Abnormalities, Leukemia, Erythroblastic, Acute, Leukemia, Megakaryoblastic, Acute, Leukemia, Monocytic, Acute, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Acute

NCT00005041 2012-11-09

R115777 in Treating Patients With Relapsed Small Cell Lung Cancer