Clinical Trials

Breast Neoplasms

NCT06482086 2024-12-05

Efficacy of Organoid-Based Drug Screening to Guide Treatment for Locally Advanced Thyroid Cancer

Phase 2 Recruiting

75 enrolled

Locally Advanced Thyroid Gland Carcinoma

NCT00537095 2024-04-19

Efficacy and Safety of Vandetanib (ZD6474) in Patients With Metastatic Papillary or Follicular Thyroid Cancer

164 enrolled 10 charts

Thyroid Neoplasms

NCT02117167 2024-01-10

SAFIR02_Lung

999 enrolled

Non-small Cell Lung Cancer Metastatic

NCT03630120 2021-07-14

Adaptive Tyrosine Kinase Inhibitor (TKI) Therapy In Patients With Thyroid Cancer

6 enrolled 9 charts

EndocrineHead & Neck

Thyroid cancer, medullary, Thyroid Cancer, Papillary, Thyroid Diseases, Thyroid Neoplasms, Adenocarcinoma, Follicular, Carcinoma, Medullary

NCT01414426 2021-01-14

Vandetanib in Preventing Head and Neck Cancer in Patients With Precancerous Head and Neck Lesions

Head & NeckOther neoplasm

20 enrolled 7 charts

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Precancerous Conditions

NCT01823068 2020-12-07

Vandetanib in Advanced NSCLC With RET Rearrangement

17 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02015065 2020-03-30

Phase II Trial of Vandetanib in Children and Adults With Wild-Type Gastrointestinal Stromal Tumors

9 enrolled 14 charts

Sarcoma

GIST

NCT02638428 2020-03-19

Genomics-Based Target Therapy for Children With Relapsed or Refractory Malignancy

Phase 2 Unknown

90 enrolled

Other solid neoplasm

Relapsed Pediatric Solid Tumor

NCT00613626 2020-02-11

Cisplatin + Etoposide +/- Concurrent ZD6474 in Previously Untreated Extensive Stage Small Cell Lung Cancer

74 enrolled 19 charts

Small Cell Lung Carcinoma

NCT01191892 2019-05-16

Carboplatin and Gemcitabine Hydrochloride With or Without Vandetanib as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Urinary Tract Cancer

82 enrolled

Urinary Bladder Neoplasms, Ureteral Neoplasms, Urethral Neoplasms

NCT00459121 2019-03-26

Vandetanib, Carboplatin, and Paclitaxel in Treating Patients With Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer That Can Be Removed by Surgery

2 enrolled 4 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02142036 2019-03-13

MetAction

50 enrolled

Tumor-Agnostic

Neoplasm Metastasis

NCT00566995 2018-10-30

Phase II Study of Vandetanib in Individuals With Kidney Cancer

37 enrolled 16 charts

Carcinoma, Renal Cell, Kidney Neoplasms

NCT00880334 2018-09-18

Randomized Study of Docetaxel +/- Vandetanib in Metastatic TCC

149 enrolled 12 charts

Urinary Bladder Neoplasms, Carcinoma, Transitional Cell

NCT00687297 2018-05-30

Study of Vandetanib Combined With Chemotherapy to Treat Advanced Non-small Cell Lung Cancer

162 enrolled 9 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00098345 2018-05-07

Efficacy and Tolerability of ZD6474 in Patients With Thyroid Cancer

40 enrolled 12 charts

Thyroid Neoplasms

NCT00500292 2018-01-25

A Phase II Study of 2 Doses of ZD6474 (Vandetanib) in Combination With FOLFOX vs FOLFOX Alone for the Treatment of Colorectal Cancer

109 enrolled 8 charts

Tumor-Agnostic

Neoplasms

NCT00481845 2017-02-07

Phase 2 Anastrozole and Vandetanib (ZD6474) in Neoadjuvant Treatment of Postmenopausal Hormone Receptor-Positive Breast Cancer

1 enrolled 8 charts

Breast Neoplasms

NCT00358956 2017-01-30

A Study To Assess ZD6474 (ZACTIMA™) Monotherapy In Locally Advanced or Metastatic Hereditary Medullary Thyroid Cancer

19 enrolled 10 charts

EndocrineHead & Neck

Familial medullary thyroid carcinoma, Thyroid Neoplasms, Carcinoma, Medullary

NCT00686036 2016-12-21

ZENITH

17 enrolled 4 charts

Prostatic Neoplasms

NCT00872989 2016-12-19

S0904: Docetaxel With or Without Vandetanib in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer

129 enrolled 17 charts

Gynecologic

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT00752986 2016-12-05

ZACFAST

39 enrolled 7 charts

Breast Neoplasms, Neoplasm Metastasis

NCT00753714 2016-10-17

ZELIG

124 enrolled 11 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Pleural Effusion

NCT00597116 2016-10-10

An Efficacy and Safety Study With Vandetanib to Treat Inoperable or Relapsed Malignant Mesothelioma

Other solid neoplasmThoracic

25 enrolled 8 charts

Mesothelioma, Recurrence

NCT00753675 2016-10-10

VANGOGH

174 enrolled 12 charts

Gastrointestinal

Biliary Tract Neoplasms, Gallbladder Neoplasms, Cholangiocarcinoma

NCT00777179 2016-10-10

Phase II of Zactima Maintenance for Locally Advanced or Metastatic Non-small-cell Lung Carcinoma (NSCLC) Following Platinum-doublet Chemotherapy

117 enrolled 15 charts

Carcinoma, Non-Small-Cell Lung

NCT00454116 2016-10-07

A Phase II, Double Blind Study of 2 Doses of ZACTIMA™(ZD6474) in Combination With FOLFIRI vs FOLFIRI Alone for the Treatment of Colorectal Cancer in Patients

106 enrolled 8 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00498797 2016-10-07

E3-Hormone Refractory Prostrate Cancer Taxotere Combination

86 enrolled 8 charts

Neoplasm Metastasis, Prostatic Neoplasms

NCT00494481 2016-09-30

E3 Breast Cancer Taxotere Combination

64 enrolled 7 charts

Advanced Breast Cancer

NCT00047840 2016-08-25

This Study is to Assess the Efficacy and Safety of ZD6474 in Subjects With Non-small Cell Lung Cancer.

129 enrolled

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT00071188 2016-08-25

ZD6474 Alone or in Combination With Paclitaxel and Carboplatin in Subjects With Previously Untreated Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC)

Carcinoma, Non-Small-Cell Lung

NCT00252746 2016-08-25

ZD6474 Phase IIa Dose Finding Multicentre Study

53 enrolled

Carcinoma, Non-Small-Cell Lung

NCT00034918 2016-08-24

This Study is to Assess the Efficacy and Safety of ZD6474 in Subjects With Metastatic Breast Cancer

44 enrolled

Breast Neoplasms, Neoplasm Metastasis

NCT00047788 2016-08-24

Efficacy Study of ZD6474 to Treat Multiple Myeloma Cancer

30 enrolled

Plasma cell

Multiple Myeloma

NCT00059722 2016-08-24

This Study is to Compare the Efficacy of ZD6474 and ZD1839 in Subjects With NSCLC.

160 enrolled

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT00066313 2016-08-24

ZD6474 in Treating Patients With Small Cell Lung Cancer

Lung Neoplasms

NCT00290537 2016-05-19

Phase II Study of ZD6474 in Advanced NSCLC

4 enrolled 3 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00995007 2016-03-29

A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas

112 enrolled 12 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma, Disease Progression

NCT00720083 2015-11-17

Chemotherapy and Radiation Therapy (RT) With or Without Vandetanib in Treating Patients With High-Risk Stage III or Stage IV Head and Neck Cancer

34 enrolled 5 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT01372813 2015-10-23

Vandetanib to Treat Advanced Kidney Cancer

3 enrolled 10 charts

Carcinoma, Renal Cell, Kidney Neoplasms, Neoplasms

NCT00410189 2015-03-23

BATTLE Program: ZD6474 in Previously Treated Subjects With NSCLC

54 enrolled 8 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00811369 2013-11-18

ZAMBONEY

126 enrolled

Breast Neoplasms

NCT00459043 2013-07-03

Docetaxel in Combination With Zactima (ZD6474) in Patients With Locally Advanced Squamous Cell Carcinoma of the the Head and Neck

30 enrolled 10 charts

Squamous Cell Carcinoma of Head and Neck

NCT00757692 2013-02-20

Efficacy and Safety Study of Vandetanib (ZD 6474) in Combination With Bicalutamide Versus Bicalutamide Alone in Patients With Chemotherapy Naive Hormone Refractory Prostate Cancer.

74 enrolled

Prostatic Neoplasms

NCT00445549 2012-06-26

Vandetanib to Treat Women With Ovarian, Fallopian Tube, or Primary Peritoneal Cancer