Clinical Trials

Neoplasm Metastasis, Thyroid Neoplasms, Carcinoma, Medullary

NCT00410761 2025-09-24

An Efficacy Study Comparing ZD6474 to Placebo in Medullary Thyroid Cancer

331 enrolled 15 charts

EndocrineHead & Neck

Familial medullary thyroid carcinoma, Thyroid Neoplasms, Carcinoma, Medullary

NCT01298323 2025-04-24

Study to Determine if Contacting Patients With MTC More Frequently Results in Earlier Detection and Treatment of Signs and Symptoms of AEs and Thus a Decrease in the Percentage of Time Patients Experience AEs During First 12 Months on Vandetanib Treatment

Phase 3 Active not recruiting

205 enrolled 9 charts

Neoplasm Metastasis, Carcinoma, Medullary

NCT04211337 2025-04-20

LIBRETTO-531

291 enrolled 16 charts 1 FDA

Carcinoma, Medullary

NCT00537095 2024-04-19

Efficacy and Safety of Vandetanib (ZD6474) in Patients With Metastatic Papillary or Follicular Thyroid Cancer

164 enrolled 10 charts

Thyroid Neoplasms

NCT04760288 2024-01-05

AcceleRET-MTC

Phase 3 Withdrawn

Carcinoma, Medullary

NCT00098345 2018-05-07

Efficacy and Tolerability of ZD6474 in Patients With Thyroid Cancer

40 enrolled 12 charts

Thyroid Neoplasms

NCT00364351 2018-01-25

Efficacy Trial Comparing ZD6474 With Erlotinib in NSCLC After Failure of at Least One Prior Chemotherapy

1,574 enrolled 13 charts

Carcinoma, Non-Small-Cell Lung

NCT00500292 2018-01-25

A Phase II Study of 2 Doses of ZD6474 (Vandetanib) in Combination With FOLFOX vs FOLFOX Alone for the Treatment of Colorectal Cancer

109 enrolled 8 charts

Tumor-Agnostic

Neoplasms

NCT01539655 2017-05-02

Vandetanib

34 enrolled

Carcinoma, Medullary

NCT00358956 2017-01-30

A Study To Assess ZD6474 (ZACTIMA™) Monotherapy In Locally Advanced or Metastatic Hereditary Medullary Thyroid Cancer

19 enrolled 10 charts

EndocrineHead & Neck

Familial medullary thyroid carcinoma, Thyroid Neoplasms, Carcinoma, Medullary

NCT00686036 2016-12-21

ZENITH

Phase 2 Terminated

17 enrolled 4 charts

Genitourinary

Prostatic Neoplasms

NCT00752986 2016-12-05

ZACFAST

Phase 2 Terminated

39 enrolled 7 charts

Breast

Breast Neoplasms, Neoplasm Metastasis

NCT01661179 2016-12-05

Evaluate the Safety and Tolerability of Vandetanib in Japanese Patients With Medullary Thyroid Carcinoma

Phase 1/2 Completed

14 enrolled 7 charts

Neoplasm Metastasis, Carcinoma, Medullary

NCT00753714 2016-10-17

ZELIG

124 enrolled 11 charts

Other solid neoplasmThoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Pleural Effusion

NCT00597116 2016-10-10

An Efficacy and Safety Study With Vandetanib to Treat Inoperable or Relapsed Malignant Mesothelioma

Phase 2 Terminated

25 enrolled 8 charts

Mesothelioma, Recurrence

NCT00753675 2016-10-10

VANGOGH

174 enrolled 12 charts

Gastrointestinal

Biliary Tract Neoplasms, Gallbladder Neoplasms, Cholangiocarcinoma

NCT00454116 2016-10-07

A Phase II, Double Blind Study of 2 Doses of ZACTIMA™(ZD6474) in Combination With FOLFIRI vs FOLFIRI Alone for the Treatment of Colorectal Cancer in Patients

106 enrolled 8 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00498797 2016-10-07

E3-Hormone Refractory Prostrate Cancer Taxotere Combination

86 enrolled 8 charts

Genitourinary

Neoplasm Metastasis, Prostatic Neoplasms

NCT00312377 2016-09-30

ZODIAC

1,690 enrolled 15 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00404924 2016-09-30

ZD6474 (ZACTIMA™) Phase III Study in EGFR Failures

1,140 enrolled 12 charts

Adenocarcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Carcinoma, Large Cell

NCT00494481 2016-09-30

E3 Breast Cancer Taxotere Combination

64 enrolled 7 charts

Breast

Advanced Breast Cancer

NCT00450138 2016-08-29

Open Label, Phase I ZD6474 Head and Neck Cancer Study

48 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT00681798 2016-08-29

Dose Escalation Study With Zactima and Chemotherapy in Metastatic Pancreas Carcinoma

8 enrolled

Gastrointestinal

Pancreatic Neoplasms

NCT00807170 2016-08-29

Investigate the Maximum Tolerated Dose of Vandetanib and Concurrent Whole Brain Radiotherapy (WBRT) in Patients With Non-small Cell Lung Cancer (NSCLC) and Brain Metastases

Phase 1 Terminated

5 enrolled

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT00496275 2016-08-26

Phase I Combination With Vinorelbine or Gemcitabine Plus Cisplatin in Locally Advanced or Metastatic NSCLC

17 enrolled

Carcinoma, Non-Small-Cell Lung

NCT00047840 2016-08-25

This Study is to Assess the Efficacy and Safety of ZD6474 in Subjects With Non-small Cell Lung Cancer.

129 enrolled

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT00071188 2016-08-25

ZD6474 Alone or in Combination With Paclitaxel and Carboplatin in Subjects With Previously Untreated Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC)

Carcinoma, Non-Small-Cell Lung

NCT00252746 2016-08-25

ZD6474 Phase IIa Dose Finding Multicentre Study

53 enrolled

Carcinoma, Non-Small-Cell Lung

NCT00499850 2016-08-25

Phase I FOLFOX Combination

18 enrolled

Tumor-Agnostic

Adenocarcinoma

NCT00506051 2016-08-25

ZD6474(Vandetanib) + Alimta Combo Study

21 enrolled

Carcinoma, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00507091 2016-08-25

Phase I Irinotecan, 5-Fluorouracil and Leucovorin Combination

24 enrolled

Tumor-Agnostic

Adenocarcinoma, Neoplasm Metastasis

NCT00034918 2016-08-24

This Study is to Assess the Efficacy and Safety of ZD6474 in Subjects With Metastatic Breast Cancer

44 enrolled

Breast

Breast Neoplasms, Neoplasm Metastasis

NCT00047788 2016-08-24

Efficacy Study of ZD6474 to Treat Multiple Myeloma Cancer

30 enrolled

Plasma cell

Multiple Myeloma

NCT00059722 2016-08-24

This Study is to Compare the Efficacy of ZD6474 and ZD1839 in Subjects With NSCLC.

160 enrolled

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT00066313 2016-08-24

ZD6474 in Treating Patients With Small Cell Lung Cancer