Clinical Trials

Neoplasm Metastasis, Thyroid Neoplasms, Carcinoma, Medullary

NCT00410761 2025-09-24

An Efficacy Study Comparing ZD6474 to Placebo in Medullary Thyroid Cancer

331 enrolled 15 charts

EndocrineHead & Neck

Familial medullary thyroid carcinoma, Thyroid Neoplasms, Carcinoma, Medullary

NCT01298323 2025-04-24

Study to Determine if Contacting Patients With MTC More Frequently Results in Earlier Detection and Treatment of Signs and Symptoms of AEs and Thus a Decrease in the Percentage of Time Patients Experience AEs During First 12 Months on Vandetanib Treatment

205 enrolled 9 charts

Neoplasm Metastasis, Carcinoma, Medullary

NCT01601808 2025-03-13

ViP

142 enrolled

Pancreatic Neoplasms

NCT00537095 2024-04-19

Efficacy and Safety of Vandetanib (ZD6474) in Patients With Metastatic Papillary or Follicular Thyroid Cancer

164 enrolled 10 charts

Thyroid Neoplasms

NCT02117167 2024-01-10

SAFIR02_Lung

999 enrolled

Non-small Cell Lung Cancer Metastatic

NCT01586624 2021-10-07

A Phase I Trial of Vandetanib (AZD6474) and Selumetinib (AZD6244) for Solid Tumours Including Non Small Cell Lung Cancer (VanSel-1)

61 enrolled 23 charts

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT01183559 2021-01-22

A Trial of ZD6474, Paclitaxel, Carboplatin, 5-Fluorouracil, and Radiation Therapy Followed by Surgery

9 enrolled 10 charts

Esophageal Neoplasms, Stomach Neoplasms

NCT01414426 2021-01-14

Vandetanib in Preventing Head and Neck Cancer in Patients With Precancerous Head and Neck Lesions

Head & NeckOther neoplasm

20 enrolled 7 charts

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Precancerous Conditions

NCT00514046 2020-12-22

Vandetanib to Treat Children and Adolescents With Medullary Thyroid Cancer

Phase 1/2 Completed

17 enrolled 25 charts

Endocrine

Multiple Endocrine Neoplasia, Carcinoma, Medullary, Multiple Endocrine Neoplasia Type 2a, Multiple Endocrine Neoplasia Type 2b

NCT01823068 2020-12-07

Vandetanib in Advanced NSCLC With RET Rearrangement

17 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02015065 2020-03-30

Phase II Trial of Vandetanib in Children and Adults With Wild-Type Gastrointestinal Stromal Tumors

9 enrolled 14 charts

Sarcoma

GIST

NCT00613626 2020-02-11

Cisplatin + Etoposide +/- Concurrent ZD6474 in Previously Untreated Extensive Stage Small Cell Lung Cancer

74 enrolled 19 charts

Small Cell Lung Carcinoma

NCT01191892 2019-05-16

Carboplatin and Gemcitabine Hydrochloride With or Without Vandetanib as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Urinary Tract Cancer

82 enrolled

Genitourinary

Urinary Bladder Neoplasms, Ureteral Neoplasms, Urethral Neoplasms

NCT02142036 2019-03-13

MetAction

50 enrolled

Neoplasm Metastasis

NCT00441142 2019-03-05

Zactima

Phase 1/2 Completed

119 enrolled 15 charts

CNSSarcoma

Glioblastoma, Gliosarcoma

NCT00566995 2018-10-30

Phase II Study of Vandetanib in Individuals With Kidney Cancer

37 enrolled 16 charts

Genitourinary

Carcinoma, Renal Cell, Kidney Neoplasms

NCT00687297 2018-05-30

Study of Vandetanib Combined With Chemotherapy to Treat Advanced Non-small Cell Lung Cancer

162 enrolled 9 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00098345 2018-05-07

Efficacy and Tolerability of ZD6474 in Patients With Thyroid Cancer

40 enrolled 12 charts

Thyroid Neoplasms

NCT00364351 2018-01-25

Efficacy Trial Comparing ZD6474 With Erlotinib in NSCLC After Failure of at Least One Prior Chemotherapy

1,574 enrolled 13 charts

Carcinoma, Non-Small-Cell Lung

NCT00500292 2018-01-25

A Phase II Study of 2 Doses of ZD6474 (Vandetanib) in Combination With FOLFOX vs FOLFOX Alone for the Treatment of Colorectal Cancer

109 enrolled 8 charts

Neoplasms

NCT01539655 2017-05-02

Vandetanib

34 enrolled

Carcinoma, Medullary

NCT00358956 2017-01-30

A Study To Assess ZD6474 (ZACTIMA™) Monotherapy In Locally Advanced or Metastatic Hereditary Medullary Thyroid Cancer

19 enrolled 10 charts

EndocrineHead & Neck

Familial medullary thyroid carcinoma, Thyroid Neoplasms, Carcinoma, Medullary

NCT00872989 2016-12-19

S0904: Docetaxel With or Without Vandetanib in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer

129 enrolled 17 charts

Gynecologic

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT01661179 2016-12-05

Evaluate the Safety and Tolerability of Vandetanib in Japanese Patients With Medullary Thyroid Carcinoma

Phase 1/2 Completed

14 enrolled 7 charts

Neoplasm Metastasis, Carcinoma, Medullary

NCT00753714 2016-10-17

ZELIG

124 enrolled 11 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Pleural Effusion

NCT00753675 2016-10-10

VANGOGH

174 enrolled 12 charts

Biliary Tract Neoplasms, Gallbladder Neoplasms, Cholangiocarcinoma

NCT00454116 2016-10-07

A Phase II, Double Blind Study of 2 Doses of ZACTIMA™(ZD6474) in Combination With FOLFIRI vs FOLFIRI Alone for the Treatment of Colorectal Cancer in Patients

106 enrolled 8 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00498797 2016-10-07

E3-Hormone Refractory Prostrate Cancer Taxotere Combination

86 enrolled 8 charts

Genitourinary

Neoplasm Metastasis, Prostatic Neoplasms

NCT00312377 2016-09-30

ZODIAC

1,690 enrolled 15 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00404924 2016-09-30

ZD6474 (ZACTIMA™) Phase III Study in EGFR Failures

1,140 enrolled 12 charts

Adenocarcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Carcinoma, Large Cell

NCT00494481 2016-09-30

E3 Breast Cancer Taxotere Combination

64 enrolled 7 charts

Breast

Advanced Breast Cancer

NCT00450138 2016-08-29

Open Label, Phase I ZD6474 Head and Neck Cancer Study

48 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT00681798 2016-08-29

Dose Escalation Study With Zactima and Chemotherapy in Metastatic Pancreas Carcinoma

8 enrolled

Pancreatic Neoplasms

NCT00496275 2016-08-26

Phase I Combination With Vinorelbine or Gemcitabine Plus Cisplatin in Locally Advanced or Metastatic NSCLC

17 enrolled

Carcinoma, Non-Small-Cell Lung

NCT00047840 2016-08-25

This Study is to Assess the Efficacy and Safety of ZD6474 in Subjects With Non-small Cell Lung Cancer.

129 enrolled

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT00071188 2016-08-25

ZD6474 Alone or in Combination With Paclitaxel and Carboplatin in Subjects With Previously Untreated Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC)

Carcinoma, Non-Small-Cell Lung

NCT00252746 2016-08-25

ZD6474 Phase IIa Dose Finding Multicentre Study

53 enrolled

Carcinoma, Non-Small-Cell Lung

NCT00499850 2016-08-25

Phase I FOLFOX Combination

18 enrolled

Adenocarcinoma

NCT00506051 2016-08-25

ZD6474(Vandetanib) + Alimta Combo Study

21 enrolled

Carcinoma, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00507091 2016-08-25

Phase I Irinotecan, 5-Fluorouracil and Leucovorin Combination

24 enrolled

Adenocarcinoma, Neoplasm Metastasis

NCT00034918 2016-08-24

This Study is to Assess the Efficacy and Safety of ZD6474 in Subjects With Metastatic Breast Cancer

44 enrolled

Breast

Breast Neoplasms, Neoplasm Metastasis

NCT00047788 2016-08-24

Efficacy Study of ZD6474 to Treat Multiple Myeloma Cancer

30 enrolled

Plasma cell

Multiple Myeloma

NCT00059722 2016-08-24

This Study is to Compare the Efficacy of ZD6474 and ZD1839 in Subjects With NSCLC.

160 enrolled

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis

NCT00066313 2016-08-24

ZD6474 in Treating Patients With Small Cell Lung Cancer

Lung Neoplasms

NCT00995007 2016-03-29

A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas

112 enrolled 12 charts

CNSSarcoma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma, Disease Progression

NCT00821080 2015-05-01

Vandetanib and Sirolimus in Patients With Recurrent Glioblastoma

33 enrolled

CNS

Glioblastoma

NCT00996723 2015-04-06

Clinical Trial Evaluating the Combination of Vandetanib and Dasatinib During and After Radiation Therapy (RT) in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG)

25 enrolled

CNS

Diffuse Intrinsic Pontine Glioma

NCT00410189 2015-03-23

BATTLE Program: ZD6474 in Previously Treated Subjects With NSCLC

54 enrolled 8 charts