Clinical Trials Browser

NCT00040222 2026-03-09

Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer

Breast Cancer, Familial, Breast Neoplasms, Hamartoma Syndrome, Multiple, Ovarian Neoplasms, Peutz-Jeghers Syndrome, Li-Fraumeni Syndrome, Risk Reduction Behavior

NCT06805734 2026-02-12

PTEN_Ped

Recruiting

50 enrolled

Hamartoma Syndrome, Multiple

NCT03050268 2026-02-09

SJFAMILY

Recruiting

1,500 enrolled

BreastCNSClassical hematologyDermatologicEndocrineGastrointestinalGynecologicLymphoidOther solid neoplasmSarcoma

Turcot syndrome, Juvenile polyposis syndrome, Choroid Plexus Carcinoma, GATA2 Deficiency, Basal Cell Nevus Syndrome, Colorectal Neoplasms, Hereditary Nonpolyposis, Fanconi Anemia, Hamartoma Syndrome, Multiple, von Hippel-Lindau Disease, Hodgkin Disease, Lymphoma, Non-Hodgkin, Melanoma, Neuroblastoma, Neurofibromatosis 1, Noonan Syndrome, Pancreatic Neoplasms, Paraganglioma, Peutz-Jeghers Syndrome, Pheochromocytoma, Rothmund-Thomson Syndrome, Adenomatous Polyposis Coli, Retinoblastoma, Rhabdomyosarcoma, Tuberous Sclerosis, Neurofibromatosis 2, Li-Fraumeni Syndrome, Adrenocortical Carcinoma, Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia Type 2a, Dyskeratosis Congenita, Genetic Predisposition to Disease, Anemia, Diamond-Blackfan, Carney Complex, Hereditary Breast and Ovarian Cancer Syndrome

NCT06888388 2025-12-08

NSM

Recruiting

4,700 enrolled

Hamartoma Syndrome, Multiple, Li-Fraumeni Syndrome

NCT06462430 2025-12-04

PTEN Hamartoma Tumor Syndrome Pediatric Patient Registry

Recruiting

100 enrolled

Macrocephaly Autism Syndrome, Autistic Disorder, Hamartoma Syndrome, Multiple, Megalencephaly

NCT07218575 2025-10-20

Double-Blind Trial of Everolimus for Improving Social Abilities in PTEN Germline Mutations

Phase 2/3 Not yet recruiting

60 enrolled

Autistic Disorder, Hamartoma Syndrome, Multiple

NCT04094675 2025-06-10

Sirolimus for Cowden Syndrome With Colon Polyposis

Phase 2 Completed

5 enrolled

Hamartoma Syndrome, Multiple

NCT02461446 2024-10-26

Natural History Study of Individuals With Autism and Germline Heterozygous PTEN Mutations

Recruiting

170 enrolled

Autistic Disorder, Hamartoma Syndrome, Multiple, Megalencephaly

NCT05671107 2024-09-19

Development and Validation of an Online Neurobehavioral Evaluation Tool for PTEN Patients

Completed

300 enrolled

Autistic Disorder, Hamartoma Syndrome, Multiple, Neurodevelopmental Disorders

NCT06523582 2024-07-26

Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients

Recruiting

750 enrolled

CNSEndocrineGastrointestinalHead & NeckNETSarcoma

Carney-Stratakis Syndrome, Carney Triad, Pituitary Adenoma, Familial Isolated, Colorectal Neoplasms, Hereditary Nonpolyposis, Hamartoma Syndrome, Multiple, von Hippel-Lindau Disease, Adenoma, Islet Cell, Neurofibromatosis 1, Paraganglioma, Pheochromocytoma, Pituitary Neoplasms, Tuberous Sclerosis, Li-Fraumeni Syndrome, Carcinoma, Medullary, Neuroendocrine Tumors, Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia Type 2a, Gastrointestinal Stromal Tumors, Hyperparathyroidism, Primary, Carney Complex

NCT06080165 2024-07-10

Sirolimus for Improving Social Abilities in People With PTEN Germline Mutations

Phase 1/2 Withdrawn

Hamartoma Syndrome, Multiple

NCT06163365 2023-12-08

ICED

Unknown

100 enrolled

Gastrointestinal

Colorectal Neoplasms, Hereditary Nonpolyposis, Hamartoma Syndrome, Multiple, Peutz-Jeghers Syndrome, Adenomatous Polyposis Coli, Stomach Neoplasms, Li-Fraumeni Syndrome

NCT00600275 2020-12-17